Nurofen, analgesic pills 200mg, 10pcs

Composition

Active ingredient:

ibuprofen – 200 mg.

Auxiliary substances:

croscarmellose sodium – 30 mg,

sodium lauryl sulfate-0.5 mg,

sodium citrate dihydrate-43.5 mg,

stearic acid-2 mg,

colloidal silicon dioxide-1 mg.

Shell composition:

carmellose sodium 0.7 mg, talc – 33 mg, acacia gum – 0.6 mg, sucrose – 116.1 mg, titanium dioxide – 1.4 mg, macrogol 6000 – 0.2 mg, ink black (Opacode S-1-277001) (shellac – 28.225%, dye iron oxide black (E172) – 24.65%, propylene glycol – 1.3%, isopropanol* – 0.55%, butanol* – 9.75%, ethanol* – 32.275%, purified water* – 3.25%).

Pharmacological action

The mechanism of action of ibuprofen, a propionic acid derivative from the group of nonsteroidal anti-inflammatory drugs (NSAIDs), is due to inhibition of prostaglandin synthesis of mediators of pain, inflammation and hyperthermic reaction. It selectively blocks cyclooxygenase 1 (COX-1) and cyclooxygenase 2 (COX-2), thereby inhibiting prostaglandin synthesis. It has a rapid directed action against pain (analgesic), antipyretic and anti-inflammatory effect. In addition, ibuprofen reversibly inhibits platelet aggregation. The analgesic effect of the drug lasts up to 8 hours. Pharmacokineticsabsorption is high, rapidly and almost completely absorbed from the gastrointestinal tract (GIT). After taking the drug on an empty stomach, the maximum concentration (Cmax) of ibuprofen in blood plasma is reached in 45 minutes. Taking the drug together with food can increase the time to reach the maximum concentration (TMAX) to 1-2 hours. Binding to plasma proteins is 90%. Slowly penetrates the joint cavity, lingers in the synovial fluid, creating higher concentrations in it than in the blood plasma. Lower concentrations of ibuprofen are found in the cerebrospinal fluid compared to blood plasma. After absorption, about 60% of the pharmacologically inactive R-form is slowly transformed into the active S-form. It is metabolized in the liver. The elimination half-life (T 1/2) is 2 hours. It is excreted by the kidneys (no more than 1% unchanged) and, to a lesser extent, with bile. In limited studies, ibuprofen has been detected in breast milk at very low concentrations.

Indications

• headache;
• migraine;
• toothache/condition after tooth extraction;
• neuralgia;
• myalgia and arthralgia;
• mild to moderate musculoskeletal injuries;
• rheumatic pain;
• algodismenorrhea;
• cold and flu symptoms;
• fever of various origins.

Contraindications

• Hypersensitivity to ibuprofen or any of the components that make up the drug.
• Complete or incomplete combination of bronchial asthma, recurrent nasal and paranasal sinus polyposis, and intolerance to acetylsalicylic acid or other NSAIDs (including in the anamnesis).
• Erosive and ulcerative diseases of the gastrointestinal tract (including peptic ulcer of the stomach and duodenum, Crohn’s disease, ulcerative colitis) active or history of ulcerative bleeding (two or more confirmed episodes of peptic ulcer disease or ulcerative bleeding).
• Bleeding or perforation of a history of gastrointestinal ulcers caused by the use of NSAIDs.
• Severe Heart Failure (NYHA Class IV-New York Heart Association Classification)
• Severe liver failure or active liver disease.
• Severe renal insufficiency (creatinine
• clearance 30 ml / min), confirmed hyperkalemia.
• Decompensated heart failure; the period after coronary artery bypass grafting.
• Cerebrovascular or other bleeding.
• Fructose intolerance, glucose-galactose malabsorption, sucrose-isomaltase deficiency.
• Hemophilia and other blood clotting disorders (including hypocoagulation), hemorrhagic diathesis.
• Pregnancy (third trimester).
• Children under 6 years of age.

Side effects

The risk of side effects can be minimized by taking the drug in a short course, at the minimum effective dose necessary to eliminate symptoms. In the elderly, there is an increased frequency of adverse reactions associated with NSAID use, especially gastrointestinal bleeding and perforation, in some cases with a fatal outcome. Side effects are mostly dose-dependent. The following adverse reactions were observed with short-term use of ibuprofen in doses not exceeding 1200 mg / day (6 tablets). In the treatment of chronic conditions and with prolonged use, other adverse reactions may occur. The frequency of adverse reactions is estimated based on the following criteria: very frequent ( 1/10), frequent (1/100 to 1/10), infrequent (1/1000 to 1/100), rare (1/10,000 to 1/1000), very rare ( 1/10,000), frequency unknown (insufficient data to estimate the frequency). Blood and lymphatic system disorders are very rare: hematopoietic disorders (anemia, leukopenia, aplastic anemia, hemolytic anemia, thrombocytopenia, pancytopenia, agranulocytosis). The first symptoms of such disorders are fever, sore throat, superficial ulcers in the mouth, flu-like symptoms, severe weakness, nosebleeds and subcutaneous hemorrhages, bleeding and bruising of unknown etiology. Immune system disorders Common: hypersensitivity reactions non-specific allergic reactions and anaphylactic reactions, respiratory tract reactions (bronchial asthma, including its exacerbation, bronchospasm, shortness of breath, dyspnea), skin reactions (pruritus, urticaria, purpura, Quincke’s edema, exfoliative and bullous dermatoses, including toxic epidermal necrolysis (Lyell’s syndrome), Stevens syndrome-Johnson’s disease, erythema multiforme), allergic rhinitis, eosinophilia. Very rare: severe hypersensitivity reactions, including swelling of the face, tongue and larynx, shortness of breath, tachycardia, hypotension (anaphylaxis, angioedema or severe anaphylactic shock). Disorders of the gastrointestinal tract are common: abdominal pain, nausea, dyspepsia (including heartburn, bloating). Rare: diarrhea, flatulence, constipation, vomiting. Very rare: peptic ulcer, perforation or gastrointestinal bleeding, melena, bloody vomiting, in some cases fatal, especially in elderly patients, ulcerative stomatitis, gastritis. Frequency unknown: exacerbation of colitis and Crohn’s disease. Liver and biliary tract disorders are very rare: impaired liver function, increased activity of hepatic transaminases, hepatitis and jaundice. Renal and urinary tract disorders are very rare: acute renal failure (compensated and decompensated), especially with prolonged use, in combination with increased urea concentration in blood plasma and the appearance of edema, hematuria and proteinuria, nephritic syndrome, nephrotic syndrome, papillary necrosis, interstitial nephritis, cystitis. Nervous system disorders are common: headache. Very rare: aseptic meningitis. Disorders of the cardiovascular system Frequency unknown: heart failure, peripheral edema, with prolonged use increased risk of thrombotic complications (for example, myocardial infarction), increased blood pressure. Respiratory and mediastinal disorders Frequency unknown: bronchial asthma, bronchospasm, shortness of breath. Laboratory indicatorshematocrit or hemoglobin (may decrease)bleeding time (may increase)plasma glucose concentration (may decrease)creatinine clearance (may decrease)plasma creatinine concentration (may increase)hepatic transaminase activity (may increase)If side effects occur, you should stop taking the drug and consult a doctor.

Interaction

Concomitant use of Nurofen tablets with acetylsalicylic acid (ASA) and other NSAIDs is not recommended.

When administered concomitantly, ibuprofen reduces the anti-inflammatory and antiplatelet effects of acetylsalicylic acid (ASA) (it is possible to increase the incidence of acute coronary insufficiency in patients receiving small doses of acetylsalicylic acid (ASA) as an antiplatelet agent after starting ibuprofen).

When prescribed with anticoagulant and thrombolytic drugs (alteplase, streptokinase, urokipase) at the same time, the risk of bleeding increases. Cefamandol, cefaperazone, cefotetan, valproic acid, plicamycin, increase the purity of hypoprothrombinemia development. Cyclosporine and gold preparations enhance the effect of ibuprofen on the synthesis of prostoglapdines in the kidneys, which is manifested by an increase in nephrotoxicity.

Ibuprofen increases the plasma concentration of cyclosporine and the likelihood of developing its hepatotoxic effects. Drugs that block tubular secretion reduce excretion and increase the plasma concentration of ibuprofen. Inducers of microsomal oxidation (phenytoin, ethanol, barbiturates, rifampicin, fepylbutazone, tricyclic anti-depressants) increase the production of hydroxylated active metabolites, increasing the risk of severe hepatotoxic reactions. Microsomal oxidation inhibitors-reduce the risk of hepatotoxic effects.

Reduces the hypotensive activity of vasodilators, natriuretic in furosemide and hydrochlorothiazide.

Reduces the effectiveness of uricosuric drugs, enhances the effect of indirect anti-coagulants, aptiaggregants, fibrinolytics. Increases the side effects of mineralocorticosteroids, glucocorticosteroids, estrogens, and ethanol. Enhances the effect of oral hypoglycemic drugs, derivatives of sulfonylureas and insulin.

Antacids and colestyramine reduce absorption. Increases the concentration of digoxin, lithium preparations, and methotrexate in the blood. Caffeine enhances the analgesic effect.

How to take, course of use and dosage

For oral use. Patients with hypersensitivity of the stomach are recommended to take the drug with meals. Only for short-term use. Please read the instructions carefully before taking the drug. Adults and children over 12 years of age: inside 1 tablet (200 mg) up to 3-4 times a day. Tablets should be washed down with water. To achieve a faster therapeutic effect in adults, the dose can be increased to 2 tablets (400 mg) up to 3 times a day. Children from 6 to 12 years: 1 tablet (200 mg) up to 3-4 times a day; the drug can only be taken if the child’s body weight is more than 20 kg. The interval between taking tablets should be at least 6 hours. The maximum daily dose for adults is 1200 mg (6 tablets). Maximum daily dose for children from 6 to 18 years: 800 mg (4 tablets). If symptoms persist or worsen after taking the drug for 2-3 days, you should stop treatment and consult a doctor. For oral use. Patients with hypersensitivity of the stomach are recommended to take the drug with meals. Only for short-term use. Please read the instructions carefully before taking the drug. Adults and children over 12 years of age: inside 1 tablet (200 mg) up to 3-4 times a day. Tablets should be washed down with water. To achieve a faster therapeutic effect in adults, the dose can be increased to 2 tablets (400 mg) up to 3 times a day. Children from 6 to 12 years: 1 tablet (200 mg) up to 3-4 times a day; the drug can only be taken if the child’s body weight is more than 20 kg. The interval between taking tablets should be at least 6 hours. The maximum daily dose for adults is 1200 mg (6 tablets). Maximum daily dose for children from 6 to 18 years: 800 mg (4 tablets). If symptoms persist or worsen after taking the drug for 2-3 days, you should stop treatment and consult a doctor. For more detailed information about the dosage and use methods, contraindications and side effects, see the instructions for use of the drug.

Overdose

Symptoms: abdominal pain, nausea, vomiting, lethargy, drowsiness, depression, headache, tinnitus, metabolic acidosis, coma, acute renal failure, low blood pressure( BP), bradycardia, tachycardia, atrial fibrillation, respiratory arrest.

Treatment: gastric lavage (only within an hour after ingestion), activated charcoal, alkaline drinking, forced diuresis, symptomatic therapy.

Description

Optimal single dose of the Active ingredient for targeted action against various types of pain**The minimum single dose of the drug (ibuprofen 200 mg), when taking which the claimed therapeutic effect can be observed. Darry K., Derry S, Moore R. A., McQuay H. J. A single oral dose of ibuprofen in the treatment of acute postoperative pain in adults,2009.

Form of production

Pills.

10 tablets in a blister (PVC / PVDC / aluminum).

One blister (10 tablets each) or two blisters (10 tablets each) together with the instructions for use are placed in a cardboard box.

Storage conditions

Store at a temperature not exceeding 25°C. Keep away from children.

Shelf

life is 3 years.

Active ingredient

Ibuprofen

Dosage form

Tablets

Purpose

Children over 6 years of age, For adults, Children as prescribed by a doctor, Pregnant women of the first and second trimester as prescribed by a doctor

Indications

Osteoarthritis, Sore Throat, Myositis, Flu, Periarthritis, Osteoarthritis, Rheumatoid Arthritis, Lumbago, Neuritis, Sciatica, Infectious Diseases, Sciatica, Arthritis, Cold, Migraine