Nurofen, express gel for joint pain 5% 50g

Composition

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of 1 g of gel for external use 5% contains:

Active ingredients: ibuprofen 50 mg

Auxiliary substances: hydroxyethylcellulose, sodium hydroxide, benzyl alcohol, isopropyl alcohol, water.

Pharmacological action

Nurofen Express (ibuprofen) gel 5% is quickly absorbed, acts directly on the source of pain and has a double effect-analgesic and anti-inflammatory drug Nurofen Express dosage form gel for external use is easy to apply and quickly absorbed into the skin. Pharmacodynamics : The drug belongs to the group of nonsteroidal anti-inflammatory drugs (NSAIDs). It has a double effect: analgesic and anti-inflammatory. Ibuprofen, being a propionic acid derivative, selectively blocks cyclooxygenase 1 (COX-1) and cyclooxygenase 2 (COX-2), as a result of which it inhibits the synthesis of prostaglandins – mediators of pain, inflammation and hyperthermic reaction. When applied to the skin, the gel has an additional cooling effect due to the rapid evaporation of the benzyl alcohol contained in the composition. Pharmacokinetics: After application to the skin, ibuprofen is detected in the epidermis and dermis after 24 hours. The maximum plasma concentration of ibuprofen when applied topically is 5% of the maximum concentration when using oral forms of ibuprofen. Clinically significant systemic absorption practically does not occur. It is metabolized in the liver. It is excreted by the kidneys (no more than 1% unchanged) and, to a lesser extent, with bile.

Indications

As a topical analgesic and anti-inflammatory agent for conditions such as muscle pain, back pain, arthritis, pain from ligament injuries and sprains, sports injuries, and neuralgia.

Contraindications

-Hypersensitivity to ibuprofen or other components of the drug. – A history of hypersensitivity reactions (bronchial asthma, rhinitis, angioedema, urticaria) in response to the use of acetylsalicylic acid or other NSAIDs. – Violations of the integrity of the skin at the site of application of the drug (including infected abrasions and wounds, wet dermatitis, eczema). – Children under 14 years of age. – Pregnancy of the third trimester. With caution, if you have any of the conditions listed in this section, you should consult a doctor before using the drug. Bronchial asthma or allergic diseases in the acute stage or in the anamnesis-possible development of bronchospasm, renal failure, liver failure, stomach ulcer, including in the anamnesis, enteritis, colitis, hemorrhagic diathesis, pregnancy I-II trimester, breastfeeding.

Side effects

The frequency of adverse reactions is estimated based on the following criteria: very frequent (≥ 1/10), frequent (≥1/100 to < 1/10), infrequent (≥1/1000 to < 1/100), rare (≥1/10000 to < 1/1000), very rare (> 1/10000), frequency unknown (frequency cannot be determined based on available data). The following adverse reactions were observed with short-term use of ibuprofen at a dose not exceeding 500 mg / day. In the treatment of chronic conditions and with prolonged use, other adverse reactions may occur. – Disorders of the immune system Frequency unknown: hypersensitivity reactions – non-specific allergic reactions and anaphylactic reactions, respiratory tract reactions (bronchial asthma, including its exacerbation, bronchospasm, shortness of breath, dyspnea), skin reactions (pruritus, urticaria, purpura, Quincke’s edema, exfoliative and bullous dermatoses, including toxic epidermal necrolysis (Lyell’s syndrome), Stevens syndrome-Johnson’s disease, erythema multiforme). – Disorders of the gastrointestinal tract Frequency unknown: abdominal pain, dyspepsia. – Renal and urinary tract disorders Frequency unknown: impaired renal function. If side effects occur, you should immediately stop using the drug and consult a doctor.

Interaction

Use with caution at the same time as the following medications: : Anticoagulants and thrombolytics, Antihypertensive agents, Acetylsalicylic acid, and other NSAIDs. It should be borne in mind that even with topical application of ibuprofen, its systemic effect cannot be completely excluded and, theoretically, with simultaneous use of ibuprofen gel with other NSAIDs, side effects may increase.

How to take, course of use and dosage

For external use only. Please read the instructions carefully before using the product. Nurofen Express gel is prescribed for adults and children over 14 years of age. When using the tube for the first time: after opening the lid, check that the safety foil on the tube neck is not damaged. Open the foil by pressing down on it with the outside of the lid. Squeeze 4 to 10 cm of the drug (equivalent to approximately 50 to 125 mg of ibuprofen) from the tube onto your hand and gently rub the gel into the skin until it is completely absorbed. Wash your hands immediately after using the drug. Re-use the drug should not be earlier than in 4 hours. Do not apply the gel more than four times within 24 hours. The maximum daily dose is 500 mg. If symptoms persist or worsen within 2 weeks of using the drug, you should stop treatment and consult a doctor. Do not exceed the indicated dose.

Overdose

Oral use of activated charcoal or gastric lavage within one hour of taking a potentially toxic dose of ibuprofen is recommended. If ibuprofen has already been absorbed, an alkaline drink may be prescribed to eliminate the acidic ibuprofen derivative by the kidneys.

Frequent or prolonged seizures should be stopped by intravenous use of diazepam or lorazepam. In case of worsening of bronchial asthma, the use of bronchodilators is recommended. In children, symptoms may occur after taking a dose exceeding 400 mg / kg of body weight.

In adults, the dose-dependent effect is less pronounced. The half-life of the drug in case of overdose is 1.5-3 hours.

Symptoms: In most patients who have taken clinically significant doses of NSAIDs, overdose symptoms are limited to nausea, vomiting, epigastric pain, or, more rarely, diarrhea.

Symptoms such as tinnitus, headache, and gastrointestinal bleeding may occur. In more severe cases, there are manifestations of the central nervous system, in particular, drowsiness, occasionally agitation, as well as disorientation or coma.

In rare cases, seizures occur. In cases of severe poisoning, metabolic acidosis and an increase in prothrombin time may develop, which is probably due to interactions between ibuprofen and circulating clotting factors. Acute renal failure, liver tissue damage, decreased blood pressure, respiratory depression, and cyanosis may occur. Patients with bronchial asthma may have an exacerbation of this disease.

Treatment: should be symptomatic and supportive, with mandatory provision of airway patency, monitoring of ECG and basic vital signs until the patient’s condition returns to normal.

Special instructions

Avoid contact with the drug in the eyes, lips and other mucous membranes, damaged areas of the skin. Do not use in combination with an occlusal (sealed) medical bandage. Avoid excessive exposure to sunlight on the area of application of the drug. Influence on the ability to drive vehicles, Mechanismamine has an impact on activities that require increased concentration of attention and speed of psychomotor reactions (driving vehicles or controlling mechanisms).

Form of production

Gel 5%.

50 g or 100 g of gel in an aluminum tube, covered from the inside with a layer of epoxy-phenolic varnish, with a polyethylene lid.

One tube is placed in a cardboard box along with the instructions for use.

Storage conditions

Store in a dry place at a temperature not exceeding 25 °C. Keep out of reach of children.

Shelf

life is 3 years.

Active ingredient

Ibuprofen

Dosage form

gel for external use

Description

Nursing mothers as prescribed by a doctor, Pregnant women as prescribed by a doctor, Children over 12 years of age, For adults

Indications

Myositis, Sciatica, Bruises, Swelling after injuries and operations, Dislocations and Sprains, Sciatica, Rheumatoid Arthritis, Osteoarthritis, Lumbago, Arthritis, Periarthritis