Composition
Active ingredients:
nystatin – 55.5 mg (250,000 units)
Auxiliary substances:
propyl parahydroxybenzoate (nipazole)Â – 2.0 mg,
citric acid monohydrate-0.075 mg,
Basis for suppositories: Â solid fat – sufficient amount before receiving a suppository weighing 2.4 g
Pharmacological action
Pharmacotherapy group
Antifungal agent
ATX code
G01AA
Pharmacodynamics :
Polyene antifungal antibiotic is highly active against yeast-like fungi of the genus Candida. The structure of the antibiotic contains double bonds that have a high tropicity to the sterol structures of the fungal cell membrane, which contributes to the incorporation of the drug molecule into the cell membrane and the formation of a large number of channels through which uncontrolled electrolyte transport is carried out; an increase in osmolarity inside the cell leads to its death. Resistance develops very slowly.
Pharmacokinetics:
When applied topically, it is practically not absorbed through the mucous membranes.
Indications
Treatment and prevention (with long-term local antimicrobial therapy) of candidiasis of the vaginal mucosa.
Use during pregnancy and lactation
The drug is contraindicated during pregnancy. Use during breastfeeding is possible since the drug is practically not absorbed through the mucous membranes, so it does not penetrate into breast milk.
Contraindications
Hypersensitivity to the components of the drug pregnancy children under 18 years of age (there are no data on the effectiveness and safety of using nystatin in the dosage form for intravaginal use in children).
Side effects
Local hypersensitivity reactions are possible.
There may be a risk of spreading resistant forms of fungi, which requires discontinuation of the drug.
Interaction
When nystatin is co-administered with clotrimazole, the activity of the latter decreases.
How to take, course of use and dosage
Vaginally. Suppository previously released from the contour cell packaging with scissors (cutting the package along the contour of the suppository) is inserted into the vagina (after hygiene procedures) 1 suppository 2 times a day (morning and evening). The course of treatment is 10-14 days.
Special instructions
During menstruation, treatment should not be interrupted.
For fungal diseases of the vagina, simultaneous treatment of the sexual partner is recommended. During the treatment period, it is recommended to avoid sexual contact.
Influence on the ability to drive vehicles and mechanisms:
During treatment with the drug, it is possible to drive vehicles and engage in other potentially dangerous activities that require increased concentration of attention and speed of psychomotor reactions.
Storage conditions
In a dry place protected from light at a temperature not exceeding 20 °C. Keep out of reach of children.
Shelf
life is 2 years. Do not use after the expiration date indicated on the package.
Active ingredient
Nystatin
Conditions of release from pharmacies
By prescription
Dosage form
suppositories vaginal
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Side effects of Nystatin suppositories vaginal 250000IU, 10pcs.
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