Composition
1 ampoule contains:
Active ingredient:
 ondansetron (in the form of dihydrate hydrochloride) 2 mg
Pharmacological action
Ondansetron is an antiemetic.
Ondansetron effectively prevents and eliminates nausea and vomiting that occur during antitumor chemotherapy or radiation therapy, as well as in the postoperative period. The mechanism of action is due to the ability of ondansetron to selectively block serotonin 5-HT3 receptors.
It is believed that the stimulation of afferent fibers of the vagus nerve with serotonin released from enterochromaffin cells of the gastrointestinal mucosa plays an important role in the occurrence of nausea and vomiting during antitumor therapy. By blocking 5-HT3 receptors, ondansetron prevents the occurrence of a gag reflex.
In addition, ondansetron inhibits the central links of the gag reflex, blocking the 5-HT3 receptors of the bottom of the IV ventricle (area postrema).
Indications
Prevention of nausea and vomiting during antitumor chemotherapy or radiation therapy; prevention and treatment of nausea and vomiting in the postoperative period.
Contraindications
I trimester of pregnancy, hypersensitivity to ondansetron.
Side effects
From the digestive tract: Â constipation/diarrhea, dry mouth, hiccups, transient elevation of BAST and ALT levels.
Nervous system and sensory disorders: Â headache, dizziness, spontaneous movement disorders and seizures, visual acuity disorders, extrapyramidal disorders (with parenteral use).
Cardiovascular and blood disorders (hematopoiesis, hemostasis): Â syncope, chest pain, in some cases with ST-segment depression, bradycardia, arrhythmia, hypotension.
Allergic reactions: Â urticaria, bronchospasm, laryngospasm, angioedema, anaphylaxis.
Other services: Â fever, hot sensation, flushing of blood to the face, hypokalemia, hypercreatinemia, local reactions (pain, redness and burning at the injection site); burning in the anus and rectum (suppositories).
How to take, course of use and dosage
The drug Ondansetron is prescribed for 8-32 mg per day, in the form of tablets, syrup, candles or injections. The dose and method of use are selected individually.
Special instructions
It is not recommended to administer in the same syringe with other drugs.
Injectable forms are diluted only with the recommended solutions. Compatible with infusion solutions of sodium and potassium chloride, dextrose, mannitol, Ringer.
Before their introduction, you should make sure that there are no large particles and color changes (if the container allows); the precipitate contained on the walls of the ampoule (it does not affect the activity and safety) is dissolved by vigorous shaking; ampoules are not autoclaved, they are protected from light.
Form of production
Solution for intravenous and intramuscular use
Storage conditions
At a temperature not exceeding 25 °C
Shelf life
2 years
Active ingredient
Ondansetron
Conditions of release from pharmacies
By prescription
Dosage form
solution for injection and infusion
Description
For adults as prescribed by a doctor, Children over 2 years of age, Children as prescribed by a doctor
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Side effects of Ondansetron, ampoules 2mg/ml, 2ml, 5pcs.
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