Composition
1 dose (45 microliters) of the drug contains:
Active ingredient:
11.25 mcg / dose 22.5 mcg / dose
Oxymetazoline Hydrochloride 11.25 mcg 22.5 mcg
Auxiliary substances:
Citric acid anhydrous 25.065 mcg
Sodium Citrate Dihydrate 172.035 mcg
Glycerol anhydrous 952,425 mcg
Water for injection 43.839 mg 43.828 mg
Pharmacological action
Anticongestive agent-alpha-adrenomimetic.
Indications
- treatment of acute respiratory diseases accompanied by a runny nose;
- allergic rhinitis;
- vasomotor rhinitis;
- to restore drainage in case of inflammation of the paranasal sinuses, eustachiitis, otitis media;
- to eliminate edema before diagnostic manipulations in the nasal passages
Contraindications
- hypersensitivity to the components of the drug;
- atrophic (dry) rhinitis;
- angle-closure glaucoma;
- condition after transsphenoidal
- pituitary surgery;dura mater surgery (in the anamnesis).
With caution
In patients suffering from diseases of the cardiovascular system (arterial hypertension, coronary heart disease, chronic heart failure, severe atherosclerosis, tachycardia, arrhythmias), impaired carbohydrate metabolism (diabetes mellitus), thyroid function disorders (hyperthyroidism), pheochromocytoma, chronic renal failure, prostatic hyperplasia with clinical symptoms (urinary retention), increased intraocular pressure, porphyria, and also in patients taking monoamine oxidase inhibitors for the previous 2 weeks and for 2 weeks after their withdrawal, tricyclic antidepressants, bromocriptine.
Side effects
Burning or dryness of the mucous membranes of the nasal cavity, dryness of the mucous membranes of the mouth and throat; sneezing; increased volume of secretions released from the nose; nosebleeds; after the effect of the drug passes, a feeling of” stuffy ” nose (reactive hyperemia).
Side effects due to the systemic action of the drug: increased blood pressure, headache, dizziness, palpitation, tachycardia, restlessness, anxiety, fatigue, drowsiness, sedation, irritability, sleep disturbance (in children), nausea, insomnia, exanthema, visual impairment (in contact with the eyes), hallucinations, angioedema, itching, convulsions, respiratory arrest (in infants).
Prolonged continuous use of vasoconstrictor drugs can lead to tachyphylaxis, atrophy of the nasal mucosa and recurrent swelling of the nasal mucosa (drug-induced rhinitis).
If any of the side effects listed in the instructions get worse or you notice any other side effects not listed in the instructions, tell your doctor.
How to take, course of use and dosage
Intranasally. Children aged 1 to 6 years: 1 injection of Oxyfrin, nasal spray dosed 11.25 mcg / dose in each nostril 2-3 times a day. The drug is used for 5-7 days. The drug can be re-prescribed only after a few days. Adults and children over 6 years of age: 1 injection of Oxyfrin, nasal spray dosed 22.5 mcg / dose in each nostril 2-3 times a day. If symptoms worsen or do not improve within 3 days, you should consult your doctor. At the recommended dose, do not use for more than 7 days without consulting a doctor. Doses higher than recommended should only be administered under medical supervision. With frequent and prolonged use of the drug, the feeling of “stuffy” nose may reappear or worsen. If these symptoms occur, you should stop treatment and consult a doctor.
Overdose
Symptoms: anxiety, restlessness, hallucinations, seizures, low body temperature, lethargy, drowsiness, coma, constriction or dilation of the pupils, fever, sweating, pallor, cyanosis, palpitation, bradycardia, arrhythmia, cardiac arrest, increased blood pressure, decreased blood pressure, nausea, vomiting, respiratory depression, respiratory arrest. Treatment: gastric lavage, taking activated charcoal (in case of accidental ingestion of the drug); symptomatic. Interaction with other medicinal products When used concomitantly with monoamine oxidase inhibitors (within the previous 2 weeks and within 2 weeks after their withdrawal), tricyclic antidepressants or other drugs that contribute to an increase in blood pressure, an increase in blood pressure may occur. The drug slows down the absorption of local anesthetics, prolongs their effect. Co-use of other vasoconstrictor drugs increases the risk of side effects.
Special instructions
Avoid contact with eyes.
To avoid the spread of infection, it is necessary to use the drug individually.
Influence on the ability to drive vehicles and mechanisms
After long-term use of cold remedies containing oxymetazoline, in doses exceeding the recommended ones, the overall effect on the cardiovascular system and central nervous system cannot be excluded.
In these cases, care should be taken when driving vehicles and engaging in other potentially dangerous activities that require increased concentration of attention and speed of psychomotor reactions.
Form of production
Metered dose nasal spray
Active ingredient
Oxymetazoline
Dosage form
nasal drops
Description
For children from birth
Indications
Cold, Runny Nose, Otitis Media, Pollinosis, Allergic Rhinitis, Sinusitis, Flu
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Side effects of Oxyfrine nasal drops 0.01%, 5ml
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