Oxyprogesterone, olive oil solution 12.5%, 1ml, 10pcs

Composition

1 ampoule with 1 ml of a solution for injection in peach or olive oil contains hydroxyprogesterone capronate 125 mg (12.5%) mg

Pharmacological action

Oxyprogesterone is an analog of the corpus luteum hormone (progesterone). It is chemically different from progesterone in that it contains a caproic acid residue at position 17. Being an ester of hydroxyprogesterone, it is metabolized more slowly than progesterone (it has a longer effect).

After a single intravenous injection of the oil solution, its effect lasts from 7 to 14 days. It is similar in biological properties to progesterone. Binding to receptors on the surface of target organ cells, it penetrates into the nucleus, where it activates DNA and stimulates RNA synthesis.

Promotes the transition of the uterine mucosa from the proliferation phase caused by follicular hormone to secretory, and after fertilization creates the necessary conditions for implantation and development of a fertilized egg.

Reduces excitability and contractility of the uterine and fallopian tube muscles, stimulates the development of the terminal elements of the breast.

Indications

Conditions associated with yellow body insufficiency:

• threatening and incipient miscarriage (prevention and treatment),
• amenorrhea (primary and secondary),
• dysfunctional uterine bleeding.

Contraindications

• hepatitis,
• liver failure,
• breast and genital cancer,
• a tendency to thrombosis.

With caution. Cardiovascular diseases, arterial hypertension, CRF, diabetes mellitus, bronchial asthma, epilepsy, migraine, depression; hyperlipoproteinemia, ectopic pregnancy, lactation.

Side effects

Nervous system disorders:  drowsiness, headache, depression, apathy, dysphoria.

From the digestive system:  cholestatic hepatitis, nausea, vomiting, decreased appetite, calculous cholecystitis.

From the genitourinary system:  decreased libido, shortened menstrual cycle, intermediate bleeding.

From the side of the senses:  visual impairment.

From the CCC side:  increased blood pressure, edema, thromboembolism (including pulmonary artery and brain vessels), thrombophlebitis, retinal vein thrombosis.

From the endocrine system:  galactorrhea, alopecia, weight gain, breast enlargement, pain and tension; hirsutism. Allergic reactions.

Local reactions:  soreness at the injection site.

How to take, course of use and dosage

Intramuscularly.

In order to prevent and treat a threatening and incipient miscarriage,0.125-0.25 g (1-2 ml of 12.5% solution) is administered 1 time a week. Apply only in the first half of pregnancy.

When amenorrhea (primary, secondary) is prescribed immediately after discontinuation of estrogenic drugs 0.25 g, once, or in 2 injections.

For the treatment of dysfunctional uterine bleedingthe drug is less convenient than progesterone, because its effect occurs slowly, but it can be used to normalize the cycle: 0.0625-0.125 g (0.5-1 ml of 12.5% solution) on the 20-22 day of the cycle.

Form of production

Solution for intramuscular use

Storage conditions

In a dark place

Shelf life

5 years

Active ingredient

Hydroxyprogesterone Caproate

Conditions of release from pharmacies

By prescription

Dosage form

solution for injection

Description

For women, For adults as prescribed by a doctor

Indications

Threatened Miscarriage