Pancreatin Renewal pills 10000 units, 20pcs

Composition

Active ingredient: Pancreatin – 125,000 mg, corresponding to the enzymatic activity: lipases – not less than 10,000 units, amylases-not less than 7,500 units, proteases-not less than 375 units Auxiliary substances: Lactose monohydrate-101,600 mg microcrystalline cellulose-52,000 mg crospovidone-18,000 mg magnesium stearate-1,867 mg silicon dioxide colloidal (aerosil) – 1,533 mg

Pharmacological action

Pharmacodynamicapancreatin is a powder from the pancreas of pigs. Pancreatic enzymes, which are part of pancreatin, have proteolytic, amylolytic and lipolytic effects and contribute to the breakdown of proteins, fats and carbohydrates, improve the functional state of the gastrointestinal tract (GIT), thus normalizing the digestive processes. Pharmacokinetics The Pancreatin 10 000 tablets are coated with an acid-resistant shell that is resistant to the effects of gastric hydrochloric acid and, thereby, protects the pancreatic enzymes contained in the preparation from inactivation. The intestinal membrane dissolves and enzymes are released at neutral or slightly alkaline pH values. Pancreatic enzymes are not absorbed from the gastrointestinal tract.

Indications

• To improve food digestion in patients with normal function of the digestive tract in the case of errors in the diet;

• the insufficiency of the exocrine function of the pancreas (chronic pancreatitis, cystic fibrosis, and others);

• chronic inflammatory-dystrophic diseases of the stomach, intestines, liver, gallbladder;

• status after resection or irradiation of the digestive tract, accompanied by disturbances of digestion, flatulence, diarrhea (in combination therapy);

• preparation for x-ray and ultrasound of the abdominal organs;

• gastrointestinal disorders functional nature (in acute intestinal infections, irritable bowel syndrome and others).

Use during pregnancy and lactation

The safety of pancreatin use during pregnancy and lactation has not been sufficiently studied. Use is possible in cases where the expected benefit to the mother exceeds the potential risk to the fetus or infant.

Contraindications

-Hypersensitivity to any of the components of the drug; – acute pancreatitis or chronic pancreatitis in the acute stage. However, it can be used in the phase of fading exacerbation when expanding the diet, if there are signs of digestive disorders; – hereditary galactose intolerance, lactase deficiency or glucose-galactose malabsorption syndrome;- children under 3 years of age (for this dosage form).

Side effects

Very rare: immediate allergic reactions (such as skin rash, urticaria, sneezing, lacrimation, bronchospasm, dyspnoea), gastrointestinal hypersensitivity. Gastrointestinal disorders Very rare: diarrhea, abdominal discomfort, abdominal pain, nausea, vomiting; formation of strictures in the ileocecal and ascending parts of the colon in patients with cystic fibrosis with high doses of pancreatin.

Interaction

It is possible to reduce the absorption of folic acid when used simultaneously with pancreatin preparations. The effect of hypoglycemic agents for oral use (such as acarbose, miglitol) may be reduced when used simultaneously with preparations of digestive enzymes containing enzymes that break down carbohydrates (for example, amylase). If you are using the above or other medications (including over-the-counter medications), please consult your doctor before using Pancreatin 10,000.

How to take, course of use and dosage

The dose of the drug is set individually, depending on the disease and the severity of symptoms. If there are no other instructions, adults should take 2-4 tablets of the drug with meals. The drug is taken orally without breaking or chewing the tablet (the effectiveness of the drug may decrease during chewing, and pancreatic enzymes may irritate the oral mucosa when released), washed down with a sufficient amount of liquid (for example, a glass of water). It is not recommended to exceed the daily dose of pancreatic enzymes corresponding to 15000-20000 units of lipase/kg of body weight. In children, the dosage is determined by the doctor.

Overdose

Symptoms: hyperuricosuria, hyperuricemia (especially in patients with cystic fibrosis, taking high doses of enzyme preparations). Treatment: symptomatic therapy, drug withdrawal.

Special instructions

In acute pancreatitis or exacerbation of chronic pancreatitis (at the stage of attenuation of exacerbation), during the period of restorative dietary nutrition, it is advisable to take the drug Pancreatin 10 000 against the background of existing and/or remaining in the future exocrine pancreatic insufficiency. Patients with cystic fibrosis, especially when taking high doses of pancreatin, may experience hyperuricosuria, so in this group of patients, it is necessary to monitor the concentration of uric acid in the urine. Strictures in the ileocecal and ascending parts of the colon are described in the above group of patients. As a precautionary measure, if you experience unusual abdominal discomfort or change in the nature of complaints, especially when taking more than 10,000 units of lipase/kg of body weight per day, a medical examination is necessary. The drug Pancreatin 10 000 contains active enzymes that, when released in the oral cavity, for example, when chewed, can damage the oral mucosa (up to the formation of ulcers). Therefore, the tablet must be swallowed whole. Influence on the ability to drive vehicles, mechanisms Pancreatin 10 000 does not affect the ability to drive vehicles and other mechanisms.

Storage conditions

At a temperature not exceeding 25 °C. Keep out of reach of children.

Shelf

life is 3 years.

Active ingredient

Pancreatin

Dosage form

Tablets