Pancreatin Renewal pills 20000 units, 20pcs

Composition

Per tablet:

Active ingredient:

Pancreatin – 250,000 mg, corresponding to the enzymatic activity: lipases-not less than 20,000 units, amylases-not less than 12,000 units, proteases – not less than 900 UNITS

Auxiliary substances:

lactose monohydrate-203,200 mg,

microcrystalline cellulose-104,000 mg,

crospovidone-36,000 mg,

magnesium stearate-3,734 mg,

colloidal silicon dioxide (aerosil) – 3,066 mg

The composition of the shell: methacrylic acid and ethylacrylate copolymer (1: 1) – 21,658 mg, talc – 13,085 mg, titanium dioxide – 8,969 mg, hypromellose – 8,520 mg, triethylcitrate – 6,910 mg, Polysorbate 80 (tween 80) – 1,200 mg, carmellose sodium (sodium carboxymethylcellulose) – 0,750 mg, simethicone emulsion 30% (dry weight) – 0,586 mg, flavoring “vanilla” – 0,463 mg, macrogol 6000 (polyethylene glycol 6000) – 0,341 mg flavor “bergamot” – 0,218 mg

Pharmacological properties

Pharmacotherapeutic group: Digestive enzyme Crestwood:  

A. 09. A. A Enzyme preparations A. 09

. A. A. 02 Pancreatin

Pharmacodynamics :

Pancreatin is a powder from the pancreas of pigs. Pancreatic enzymes, which are part of pancreatin, have proteolytic, amylolytic and lipolytic effects and contribute to the breakdown of proteins, fats and carbohydrates, improve the functional state of the gastrointestinal tract (GIT), thus normalizing the digestive processes.

Pharmacokinetics: Tablets of the drug Pancreatin 20 000 is coated with an acid-resistant shell that is resistant to the effects of gastric hydrochloric acid and, thereby, protects the pancreatic enzymes contained in the preparation from inactivation. The intestinal membrane dissolves and the enzymes are released at neutral or slightly alkaline pH values. Pancreatic enzymes are not absorbed from the gastrointestinal tract.

Indications

– the Insufficiency of the exocrine function of the pancreas (chronic pancreatitis, cystic fibrosis, and others);

– chronic inflammatory-dystrophic diseases of the stomach, intestines, liver, gallbladder;

status after resection or irradiation of the digestive tract, accompanied by disturbances of digestion, flatulence, diarrhea (in combination therapy);

– for improving food digestion in patients with normal function of the digestive tract in the case of errors in the diet;

– preparation for x-ray and ultrasound of the abdominal cavity;

– disorders of the digestive tract of a functional nature (in acute intestinal infections, irritable bowel syndrome and others).

Use during pregnancy and lactation

The safety of pancreatin use during pregnancy and lactation has not been sufficiently studied. Use is possible in cases where the expected benefit to the mother exceeds the potential risk to the fetus or infant.

Contraindications

-Hypersensitivity to any of the components of the drug;

– acute pancreatitis or chronic pancreatitis in the acute stage. However, it is possible to use in the phase of fading exacerbation when expanding the diet, if there are signs of digestive disorders;

– hereditary galactose intolerance, lactase deficiency or glucose-galactose malabsorption syndrome;

– children under 3 years of age (for this dosage form).

Side effects

Possible side effects are listed below by descending frequency: very common (≥1/10), common (≥1/100 to <1/10), uncommon (≥ 1/1000 to < 1/100), rare (≥ 1/10000 to < 1/1000), very rare (up to

Immune system disorders

Very rare: immediate allergic reactions (such as skin rash, urticaria, sneezing, lacrimation, bronchospasm, dyspnoea), gastrointestinal hypersensitivity.

Disorders of the gastrointestinal tract

Very rare: diarrhea, abdominal discomfort, abdominal pain, nausea, vomiting; formation of strictures in the ileocecal and ascending parts of the colon in patients with cystic fibrosis with high doses of pancreatin.

Disorders of the genitourinary system

Frequency unknown: hyperuricosuria (see section “Special instructions”).

If you experience any of the side effects listed in the instructions, or they get worse, or you notice any other side effects not listed in the instructions, tell your doctor.

Interaction

It is possible to reduce the absorption of folic acid when used simultaneously with pancreatin preparations.

The effect of hypoglycemic agents for oral use (such as acarbose, miglitol) may be reduced when used simultaneously with preparations of digestive enzymes containing enzymes that break down carbohydrates (for example, amylase). If you are using the above or other medications (including over-the-counter medications), before using the drug Pancreatin 20 000 consult your doctor.

How to take, course of use and dosage

Dosage of the drug Pancreatin 20 000 is set individually depending on the disease and the severity of symptoms. If there are no other instructions, adults should take 1-2 tablets of the drug 20 000 pancreatin during meals. The drug is taken orally, without breaking or chewing the tablet (effectiveness of the drug Pancreatin 20 000 may be reduced by chewing, and pancreatic enzymes released may irritate the oral mucosa), washed down with a sufficient amount of liquid (for example, a glass of water).

It is not recommended to exceed the daily dose of pancreatic enzymes corresponding to 15000-20000 units of lipase/kg of body weight.

Increasing the dose should only be carried out under the supervision of a doctor, focusing on the symptoms (for example, reduction of steatorrhea and abdominal pain). The duration of treatment is determined by the doctor and can vary from several days (in case of digestive disorders due to errors in the diet) to several months or even years (if permanent replacement therapy is required).

In children, the dosage is determined by the doctor.

Dosage for children and adults with cystic fibrosis

In patients with cystic fibrosis, the dose should be selected taking into account the severity of the symptoms of the disease, the results of steatorrhea control and maintaining an adequate nutritional status (see the section “Special instructions”).

The dose should not exceed 10,000 units of lipase/kg of body weight per day.

In children, the dosage regimen and duration of treatment is set by the doctor depending on the severity of digestive disorders and the composition of the diet, at the rate of 1000 units of lipase/kg of body weight of the child for each meal for children under 4 years of age and 500 UNITS of lipase/kg of body weight of the child for each meal for children over 4 years.

If there is no improvement after treatment, or if the symptoms worsen or new symptoms appear, you should consult your doctor.

Use the drug only according to the indications, the method of use and in the doses indicated in the instructions.

Overdose

Symptoms: hyperuricosuria, hyperuricemia (especially in patients with cystic fibrosis, taking high doses of enzyme preparations).

Treatment: symptomatic therapy, drug withdrawal.

Special instructions

In case of acute pancreatitis or exacerbation of chronic pancreatitis (at the stage of attenuation of exacerbation), during the period of restorative dietary nutrition, it is advisable to take the drug Pancreatin 20 000 against the background of existing and/or remaining in the future exocrine pancreatic insufficiency.

Patients with cystic fibrosis, especially when taking high doses of pancreatin, may experience hyperuricosuria, so in this group of patients, it is necessary to monitor the concentration of uric acid in the urine.

Strictures in the ileocecal and ascending parts of the colon are described in the above group of patients.

As a precautionary measure, if you experience unusual abdominal discomfort or change in the nature of complaints, especially when taking more than 10,000 units of lipase/kg of body weight per day, a medical examination is necessary.

Medication Pancreatin 20 000 contains active enzymes that, when released in the oral cavity, for example, when chewed, can damage the oral mucosa (up to the formation of ulcers). Therefore, the tablet must be swallowed whole. Influence on the ability to drive vehicles and fur. : Medication Pancreatin 20 000 does not affect the ability to drive vehicles and other mechanisms.

Form of production

Enteric-soluble film-coated tablets,20000 units.

Storage conditions

At a temperature not exceeding 25 °C.

Keep out of reach of children.

Shelf

life is 3 years.

Do not use after the expiration date.

Active ingredient

Pancreatin

Dosage form

Tablets