Papazole pills, 20pcs

Composition

Active ingredients:

bendazole hydrochloride (dibazole) – 30 mg,

papaverine hydrochloride-30 mg;

excipients:

potato starch-56 mg,

talc-3 mg,

stearic acid-1 mg,

talc,

stearic acid-1 mg

Pharmacological action

Combined drug, has antispasmodic, hypotensive, vasodilating effect. Bendazol is an antispasmodic agent of myotropic action; it has a hypotensive, vasodilating effect, stimulates the function of the spinal cord, and has moderate immunostimulating activity.

Papaverine is an antispasmodic agent that has a hypotensive effect. Inhibits phosphodiesterase, causes the accumulation of cAMP in the cell and a decrease in calcium content, reduces the tone and relaxes the smooth muscles of internal organs (gastrointestinal tract, respiratory and genitourinary system) and blood vessels.

In large doses, it reduces the excitability of the heart muscle and slows down intracardiac conduction. The effect on the central nervous system is weak (in large doses it has a sedative effect).

Indications

-arterial hypertension (labile);

– spasm of peripheral arteries and blood vessels of the brain;

– spasm of smooth muscles of internal organs (including gastric and duodenal ulcer, pyloric spasm, intestinal colic, cholecystitis, spastic colitis);

— poliomyelitis (residual phenomena);

— peripheral paralysis of the facial nerve.

Contraindications

-violations of AV conduction;

– epileptic syndrome;

– bronchial

obstructive syndrome— – children under 3 years of age;

– hypersensitivity to the components of the drug.

Use with caution in patients with reduced intestinal motility, traumatic brain injury, liver and / or kidney failure, hypothyroidism, adrenal insufficiency, prostatic hyperplasia, during pregnancy and lactation.

Side effects

From the digestive system: nausea, constipation.

From the central nervous system: dizziness.

From the cardiovascular system: AV block, arrhythmias, decreased myocardial contractility.

Other: allergic reactions, increased sweating.

Composition

Pharmacodynamic interaction: when used concomitantly with antispasmodics, sedatives, diuretics (dichlotiazid, diacarb, furosemide, spironolactone, etc. ), tricyclic antidepressants, novocainamide, reserpine, quinidine sulfate, the hypotensive effect may increase.

Weakens the effect of anticholinesterase drugs (galantamine, proserin, physostigmine, etc. ) on smooth muscles; reduces the antiparkinsonian effect of levodopa.

With the combined use of Papazole and nitrofurantoin, hepatitis may develop. Pharmacokinetic: adsorbents, astringents and enveloping agents reduce the absorption of the drug in the gastrointestinal tract.

How to take, course of use and dosage

Inside, adults-1-2 tablets 2-3 times a day.

The course of treatment is individual, usually 2-4 weeks.

For children — as prescribed by the attending physician.

Special instructions

During the treatment period, alcohol intake should be excluded.

With caution and in small doses, the drug should be prescribed to elderly and debilitated patients, as well as patients with traumatic brain injury, impaired liver and kidney function, hypothyroidism, adrenal insufficiency, and prostatic hypertrophy.

Form of production

Tablets

Storage conditions

Store at a temperature not exceeding 25 C.

Shelf life

5 years

Active ingredient

Bendazol, Papaverine

Dosage form

Tablets

Description

Children over 12 years old, For adults

Indications

Biliary dyskinesia, Hypertension, Colitis, Cholecystitis, Gastric ulcer and duodenal ulcer, Spasm of the gastrointestinal tract, Cholelithiasis, Urolithiasis