Paracetamol pills 500mg, 10pcs

Product description

Minimum order quantity-5 pieces

Composition

Composition per tablet

Active ingredient:

paracetamol-500 mg;

excipients:

potato starch,

croscarmellose sodium (sodium croscarmellose),

povidone (polyvinylpyrrolidone low molecular weight medical),

stearic acid,

talc.

Pharmacological action

Paracetamol has analgesic and antipyretic effects.

The drug blocks cyclooxygenase in the central nervous system, affecting the centers of pain and thermoregulation.

In inflamed tissues, cellular peroxidases neutralize the effect of paracetamol on cyclooxygenase, which explains the absence of a significant anti-inflammatory effect.

The drug does not adversely affect the water-salt metabolism and the mucous membrane of the gastrointestinal tract.

Indications

Pain syndrome of mild to moderate intensity (arthralgia, myalgia, neuralgia, migraine, tooth and headache, algodismenorrhea), fever in infectious and inflammatory diseases (including viral infections).

Contraindications

-individual hypersensitivity to the components of the drug;

– children under 6 years of age (for this dosage form).

With caution

Renal and hepatic insufficiency, viral hepatitis, alcoholic liver damage, alcoholism, benign hyperbilirubinemia (Gilbert, Dubin-Johnson and Rotor syndromes), glucose-6-phosphate dehydrogenase deficiency, elderly age, pregnancy, lactation.

Side effects

Nausea, vomiting, abdominal pain.

Allergic reactions (skin rash, pruritus, urticaria, angioedema).

Rarely-leukopenia, agranulocytosis, thrombocytopenia.

With prolonged use in large doses – hepatotoxic and nephrotoxic (interstitial nephritis and papillary necrosis) effect; hemolytic anemia, aplastic anemia, methemoglobinemia, pancytopenia.

Interaction

Inducers of microsomal oxidation in the liver (phenytoin, ethanol, barbiturates, flumecinol, rifampicin, phenylbutazone, tricyclic antidepressants) increase the production of hydroxylated active metabolites, which causes the possibility of severe intoxication with small overdoses.

Long-term use of barbiturates reduces the effectiveness of paracetamol.

Concomitant use with ethanol increases the risk of acute pancreatitis.

Microsomal oxidation inhibitors (including cimetidine) reduce the risk of hepatotoxic effects.

When taken together with nonsteroidal anti-inflammatory drugs, including salicylates, the nephrotoxic effect of paracetamol increases.

Diflunisal increases the plasma concentration of paracetamol by 50%, which increases the risk of hepatotoxicity.

Paracetamol enhances the effect of indirect anticoagulants and reduces the effectiveness of uricosuric drugs.

How to take, course of use and dosage

Inside, before a meal or 1-2 hours after a meal, with plenty of liquid.

Adults and adolescents over 12 years of age (body weight more than 40 kg) single dose-500 mg; maximum single dose-1 g. Maximum daily dose-4 g.

For children, the dose of paracetamol is calculated depending on age and body weight.

Children aged 6-9 years (weight up to 30 kg): single dose-250 mg (1/2 tablet); maximum daily dose-1 g; at the age of 9-12 years (weight from 30 to 40 kg): single dose – 250-500 mg (1/2 tablet – 1 tablet), maximum daily dose – 2 g (4 tablets).

The frequency of reception is no more than 4 times a day with an interval of at least 4 hours.

In patients with impaired liver and kidney function, with benign hyperbilirubinemia, and in the elderly, the daily dose should be reduced and the interval between doses increased.

The duration of treatment is no more than 3 days as an antipyretic and no more than 5 days as an analgesic. Continuation of treatment with the drug is possible only after consulting a doctor!!!

Do not exceed the prescribed dose! An overdose of paracetamol may cause liver failure.

Overdose

Symptoms:  pallor of the skin, nausea, vomiting, anorexia, abdominal pain; impaired glucose metabolism, metabolic acidosis. Symptoms of impaired liver function may appear 12-48 hours after an overdose. In severe overdose – liver failure with progressive encephalopathy, coma, death; acute renal failure with tubular necrosis; arrhythmia, pancreatitis. The hepatotoxic effect in adults is manifested when taking 10 g or more.

Treatment:  gastric lavage no later than 4 hours after poisoning, taking adsorbents (activated carbon). The introduction of methionine is relevant for 8-9 hours, acetylcysteine-for 8 hours. The need for additional therapeutic measures is determined depending on the concentration of paracetamol in the blood, as well as on the time elapsed after taking it.

Special instructions

Concomitant use of paracetamol with other paracetamol-containing medications should be avoided, as this may cause an overdose of paracetamol.

When using the drug for more than 5 days, peripheral blood parameters and the functional state of the liver should be monitored.

Paracetamol distorts the results of laboratory tests of glucose and uric acid in blood plasma.

Form of production

Pills.

Storage conditions

Store in a dry place, protected from light, at a temperature not exceeding 25 °C

Shelf life

4 years

Active ingredient

Paracetamol

Dosage form

Tablets

Description

For adults and Children over 6 years of age

Indications

Cold, Migraine, Fever, Neuritis, Arthrosis and arthritis, Acute respiratory viral infections, Flu, Myalgia, Neuralgia