Parnavel capsules 8mg, 30pcs

Composition

1 capsule contains: Active ingredient: – perindopril erbumin-4.00 mg; – perindopril erbumin-8.00 mg

Pharmacological action

Perindopril, an angiotensin-converting enzyme (ACE) inhibitor, or kininase II, is an exopeptidase. Converts angiotensin I to the vasoconstrictor angiotensin II and destroys the vasodilator bradykinin to an inactive heptapeptide. Inhibition of ACE activity leads to a decrease in the concentration of angiotensin II and an increase in plasma renin activity (suppressing the negative feedback of renin release) and a decrease in aldosterone secretion. Since ACE also destroys bradykinin, ACE inhibition also leads to an increase in the activity of the circulating and tissue kallikrein-kinin system, while the prostaglandin system is activated. Perindopril has a therapeutic effect due to the active metabolite perindoprilat. Perindopril reduces both systolic and diastolic blood pressure (BP) in the “lying” and “standing” positions. Perindopril reduces total peripheral vascular resistance (OPSS), which leads to a decrease in blood pressure. At the same time, peripheral blood flow accelerates. However, the heart rate (HR) does not increase. Renal blood flow tends to increase, while glomerular filtration rate does not change. The maximum antihypertensive effect is achieved 4-6 hours after a single oral use of perindopril; the antihypertensive effect persists for 24 hours. Lowering blood pressure develops quickly. Stabilization of the antihypertensive effect is observed after 1 month of therapy and persists for a long time. Discontinuation of therapy is not accompanied by the development of “withdrawal”syndrome. Perindopril reduces left ventricular hypertrophy. With prolonged use, it reduces the severity of interstitial fibrosis, normalizes the isoenzyme profile of myosin. Increases the concentration of high-density lipoproteins (HDL), reduces the concentration of uric acid in patients with hyperuricemia. Perindopril improves the elasticity of large arteries, eliminates structural changes in small arteries. Perindopril normalizes heart function, reducing pre-and afterload. In patients with chronic heart failure (CHF) on the background of perindopril therapy, it was noted:  * reduction of filling pressure in the left and right ventricles • * reduction of OPSS, * increased cardiac output and heart index. Taking the initial dose of perindopril 2 mg in patients with CHF of NYHA functional class 1-II is not accompanied by a statistically significant decrease in blood pressure compared to placebo.

Indications

-arterial hypertension;- chronic heart failure;- prevention of recurrent stroke (as part of complex therapy with indapamide) in patients with a history of cerebrovascular diseases (stroke or transient cerebral ischemic attack);- stable coronary heart disease (CHD): reducing the risk of developing cardiovascular complications in patients who have previously had a myocardial infarction and / or coronary revascularization.

Contraindications

• Hypersensitivity to perindopril or other components of the drug, as well as to other ACE inhibitors;
• pregnancy; breastfeeding;
• a history of angioedema (hereditary, idiopathic or angioedema due to taking ACE inhibitors);
• age under 18 years (efficacy and safety have not been established).

Concomitant use with aliskiren and aliskiren-containing drugs in patients with diabetes mellitus and/or il and moderate or severe renal impairment (glomerular filtration rate (GFR) less than 60 ml/min/1.73 m2 of body surface area), concomitant use with angiotensin 11 receptor antagonists (ARA II) in patients with diabetic nephropathy.

How to take, course of use and dosage

Inside. It is recommended to take it once a day, before meals, preferably in the morning, without chewing. The dose of the drug is selected individually for each patient, depending on the severity of the disease and individual response to treatment.

Active ingredient

Perindopril

Conditions of release from pharmacies

By prescription

Dosage form

Capsules

Description

For adults as directed by your doctor

Indications

Angina, Heart failure, Hypertension, Prevention of heart attacks and strokes