Composition
Active ingredient: Nicotinoyl gamma-aminobutyrate sodium-50 mg and 100 mgcompliant substances: 0.1 M hydrochloric acid solution-up to pH from 6.7 to 8.0 Water for injection-up to 1 ml
Pharmacological action
Nootropic agent, dilates the blood vessels of the brain. It has a tranquilizing and mild psychostimulating effect, antiplatelet and antioxidant effects. Improves the functional state of the brain by normalizing tissue metabolism and influencing cerebral blood circulation (increases the volume and linear velocity of cerebral blood flow, has a vasodilating, antiplatelet, antioxidant effect, improves microcirculation). When taking a course, it increases physical and mental performance, reduces headaches, improves memory, normalizes sleep; helps to reduce or disappear feelings of anxiety, tension, fear, and emotional incontinence. Promotes recovery of central motor and speech disorders of vascular or traumatic origin. Improves blood circulation in the vessels of the retina and optic nerve. Pharmacokinetics: Absorption is fast and complete with all routes of use. Penetrates through the blood-brain barrier, is retained for a long time in the body’s tissues. Bioavailability – 50-88%. It is mainly excreted by the kidneys in unchanged form. The elimination half-life is 0.51 hours.
Indications
For adults:
- chronic cerebrovascular insufficiency (dyscirculatory encephalopathy, consequences of cerebral circulatory disorders), condition after traumatic brain injury, vegetative dystonia syndrome, as part of the complex therapy of depressive disorders of various origins in the elderly.
- as part of a comprehensive treatment for chronic alcoholism (reduction of asthenic, asthenoneurotic, postpsychotic, pre-relapse conditions in alcoholic encephalopathy).
- as part of the complex therapy of primary open-angle glaucoma with compensated intraocular pressure (to stabilize visual function).
- as part of the complex therapy of vegetative dystonia syndrome, accompanied by anxiety, fear, increased irritability, asthenia, emotional lability.
- to improve the tolerance of physical and mental loads, increase stress resistance (for people who are in stressful and extreme conditions of activity; to restore the physical performance of athletes, to increase resistance to physical and mental loads).
Children over 3 years of age and adults in urological practice for urinary disorders to improve the adaptive function of the bladder (reduction of detrusor hypoxia).
Contraindications
Hypersensitivity, chronic renal failure, pregnancy, lactation, children under 3 years of age (in children over 3 years of age, it is used for urination disorders).
Side effects
Low blood pressure, dizziness, headache, mild nausea, irritability, agitation, anxiety, allergic reactions (skin rash, itching).
Interaction
Shortens the effect of barbiturates, enhances the effect of narcotic analgesics.
How to take, course of use and dosage
Intravenous drip or jet (slow), intramuscularly. Before drip use, the contents of the ampoule are dissolved in 200 ml of 0.9% sodium chloride solution. For chronic cerebrovascular insufficiency: enter 100-200 mg 1 time a day for 10 days intravenously, then intramuscularly. The course of treatment is 15-30 days. If the condition improves, they switch to oral forms in a daily dose of 50-150 mg. Repeat course – in 5-6 months. As part of complex therapy in the treatment of depressive states of the elderly: 50-200 mg is administered per day for 10-15 days. In the treatment of chronic alcoholism,100 mg is administered per day for a course of 6-15 days. To restore performance under increased loads,200 mg is administered in a daily dose for 10-15 days, for athletes – in the same dose for 14 days of the training period. As part of the complex therapy of vegetative dystonia syndrome,100-200 mg is prescribed for 10-15 days. In the complex treatment of primary open-angle glaucoma,100-200 mg is administered per day for 10 days. In the treatment of urinary disorders: intramuscularly administered 100 mg (for children from 3 to 10 years),200 mg per day (for children over 11 years and adults).
Overdose
Increased severity of dose-dependent side effect symptoms. Treatment is symptomatic.
Special instructions
The drug may negatively affect the performance of potentially dangerous activities that require special attention and quick response (driving a car, working with moving mechanisms, etc. ). Influence on the ability to drive vehicles and mechanisms: During treatment, care should be taken when driving vehicles and engaging in other potentially dangerous activities that require increased concentration of attention and speed of psychomotor reactions.
Form of production
Solution for intravenous and intramuscular use of 50 mg / ml and 100 mg / ml. 2 ml in ampoules made of glass of hydrolytic class 1 with a color marking ring. 5 ampoules in a contour cell package made of polyvinyl chloride film without foil. 2 contour cell packages of 5 ampoules together with the instructions for use are placed in a pack of cardboard.
Storage conditions
In a dark place at a temperature not exceeding 25 °C. Keep out of reach of children.
Shelf
life is 3 years.
Active ingredient
Nicotinoyl gamma-aminobutyric acid
Conditions of release from pharmacies
By prescription
Dosage form
solution for injection and infusion
Description
For the elderly, Children over 3 years of age, Adults as prescribed by a doctor, Children as prescribed by a doctor
Indications
Vegetative-vascular disorders, Concussion and other traumatic brain injuries, Glaucoma, Intense exercise, Depression, Cerebral circulatory disorders
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Side effects of Picamilon solution for intravenous and intramuscular use 50mg/ml 2ml ampoules, 10pcs.
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