Pimafucin, 2% cream, 30g

Composition

Cream for external use 2% from white to light yellow color.

1 g of cream contains:

Active ingredients:

natamycin 20 mg.

Auxiliary substances:

cetyl ether wax,

decyloleate (cetiol V),

sodium lauryl sulfate,

propylene glycol,

propyl parahydroxybenzoate,

methyl parahydroxybenzoate,

cetostearyl alcohol,

purified water.

In a tube of aluminum or plastic 30 g of cream.

The package contains 1 tube.

Pharmacological action

Clinical and pharmacological group

Antifungal drug for external use.

Pharmacological action

Polyene antifungal antibiotic from the macrolide group, which has a wide spectrum of action. It has a fungicidal effect. Natamycin binds sterols of the fungal cell membrane, disrupting its integrity and function, which leads to cell death.

Pharmacodynamics

Most pathogenic yeast fungi, especially Candida albicans, are susceptible to natamycin. Dermatophytes are less sensitive to natamycin. Natamycin resistance has not been reported in clinical practice.

Pharmacokinetics

When applied to the skin and mucous membranes, it is practically not subject to systemic absorption, so it does not have a systemic effect.

Indications

• Fungal diseases of the skin and mucous membranes caused by pathogens sensitive to the drug (including vaginitis, vulvitis, vulvovaginitis, balanoposthitis caused by fungi of the genus Candida; candidiasis of the skin and nails; otitis externa, either primarily caused by fungi or complicated by candidiasis; dermatomycosis).

Contraindications

Contraindication to the use of Pimafucin is:

• hypersensitivity to the components of the drug.

Side effects

When using Pimafucin, the following symptoms may occur: :

Local reactions: mild irritation, burning sensation.

Interaction

Drug interaction of Pimafucin® with other medicinal products was not detected.

How to take, course of use and dosage

Method of use and dosage regimen for different age groups and depending on the disease

For dermatomycosis (including candidiasis of the skin, diaper rash in children), the cream is applied to the affected skin surface one or more (up to 4) times a day.

With mycosis of the external auditory canal, the affected surface is smeared with cream once or several times (up to 4 times) a day. Before applying the drug, the ear is cleaned. After applying the drug, a tampon made of natural material (cotton, wool) is placed in the ear canal.

With vulvitis, vulvovaginitis, balanoposthitis, the cream is applied to the affected areas of the skin once or several times a day.

The duration of the course of treatment is set individually. After the symptoms of the disease disappear, it is recommended to continue treatment for several more days.

Overdose

Currently, no cases of overdose of Pimafucin® have been reported.

Special instructions

Precautions when taking the drug

In the case of a chronic or recurrent infection, topical treatment may be supplemented with Pimafucin tablets.

Use in pediatrics

Pimafucin ® cream for external use can be prescribed to newborns.

Interaction with alcohol

There are no data on interaction with alcohol.

Conditions of release from pharmacies

The drug is approved for use as an over-the-counter product.

Form of production

Cream for external use

Storage conditions

At a temperature not exceeding 25 °C

Shelf life

4 years

Active ingredient

Natamycin

Dosage form

cream

Description

For adults as prescribed by a doctor, Children as prescribed by a doctor, Pregnant women as prescribed by a doctor, Nursing mothers as prescribed by a doctor

Indications

Otitis Media, Fungus, Inflammation of the female genital organs, Thrush, Skin fungus