Pizenum-sanivel enteric-soluble pills 40mg, 28pcs

Composition

>of 1 tab. contains: Active ingredients: pantoprazole sodium sesquihydrate 45.1 mg, which corresponds to the content of pantoprazole-40 mg. Excipients: sodium carbonate-10 mg, mannitol-42.7 mg, crospovidone-50 mg, povidone K 90-4 mg, calcium stearate-3.2 mg.

Shell composition:  opadray yellow (hypromellose – 79.96%, povidone K 25-1.52%, titanium dioxide-1.4%, iron oxide yellow dye-0.12%, propylene glycol-17%) – 20 mg. Composition of the enteric shell:  copolymer of methacrylic acid and ethyl acrylate [1: 1] (Eudragit L-30 D-55) – 14.2 mg, triethyl citrate-1.48 mg

Pharmacological action

Pharmaco-therapeutic group: Gastric glands secretion reducing agent-proton pump inhibitorpharmacological action Inhibitor of H+ – K+ – ATPASE. Blocks the final stage of hydrochloric acid secretion, reduces the level of basal and stimulated (regardless of the type of stimulus) secretion of hydrochloric acid in the stomach. In Helicobacter pylori-associated duodenal ulcer, such a decrease in gastric secretion increases the sensitivity of microgranismus to antibiotics. Pantoprazole has its own antimicrobial activity against Helicobacter pylori.

Indications

Acute gastric or duodenal ulcer, Zollinger-Ellison syndrome, Helicobacter pylori eradication (in combination with antibacterial therapy), reflux esophagitis.

Use during pregnancy and lactation

If pantoprazole should be used during pregnancy, the intended benefit to the mother and the potential risk to the fetus should be evaluated.

If it is necessary to use it during lactation, the question of stopping breastfeeding should be decided.

Experimental studies have shown that pantoprazole is excreted in breast milk.

Contraindications

Dyspepsia of neurotic origin, malignant diseases of the gastrointestinal tract, hypersensitivity to pantoprazole.

Side effects

From the digestive system:  diarrhea; rarely – nausea, upper abdominal pain, flatulence.

From the central nervous system:  headache; rarely-weakness, dizziness; in isolated cases-initial manifestations of depressive states, visual disturbances.

Dermatological reactions:  rarely-rash, itching.

Other services:  weakness, dizziness; in some cases – edema, fever.

Interaction

When used concomitantly, pantoprazole may alter the absorption of drugs whose absorption depends on the pH of gastric contents (ketoconazole).

Due to the fact that pantoprazole is metabolized in the liver by the cytochrome P450 enzyme system, the possibility of drug interaction with drugs metabolized by the same enzyme system cannot be excluded.

How to take, course of use and dosage

The average therapeutic dose is 40 mg / day. The maximum daily dose is 80 mg. The duration of the course of therapy is set depending on the indications, but it should not exceed 8 weeks.

Special instructions

Before starting therapy, the possibility of malignancy in the stomach and esophagus should be excluded, since the use of pantoprazole reduces the severity of symptoms and may delay the establishment of a correct diagnosis. The diagnosis of reflux esophagitis requires mandatory endoscopic confirmation.

When used in patients with impaired liver function, the activity of liver enzymes in blood plasma should be regularly monitored and, if it increases, pantoprazole should be discontinued.

Active ingredient

Pantoprazole

Conditions of release from pharmacies

By prescription

Dosage form

Tablets