Plendil, retard pills 5mg, 30pcs

Composition

Active ingredient:

felodipine 2.5 mg,5 mg or 10 mg;

Auxiliary substances:

paraffin;

ethanol;

hydroxypropyl cellulose;

hydroxypropylmethyl cellulose;

iron oxide E 172;

lactose anhydrous;

MCC;

polyethylene glycol 6000;

polyoxyl 40 hydrogenated castor oil;

propyl gallate;

sodium aluminum silicate;

sodium stearyl fumarate;

titanium dioxide E 171;

purified water

Pharmacological action

Plendil – antihypertensive, antianginal.

Blocks calcium channels, inhibits the flow of calcium ions into the smooth muscle cells of arterial vessels, causes their expansion, reduces OPSS, lowers blood pressure, afterload on the heart, increases coronary blood flow, improves the balance of oxygen supply/consumption by the myocardium.

Pharmacokinetics

It is completely absorbed from the gastrointestinal tract. Systemic bioavailability — 15%. It binds to plasma proteins by 99%. The plasma concentration is directly proportional to the dose. It is metabolized in the liver. T_1/2-24 h. 70% is excreted in the urine (less than 0.5% of the dose is unchanged), the rest is excreted in the feces.

Indications

Arterial hypertension, angina pectoris.

Use during pregnancy and lactation

It is contraindicated during pregnancy and lactation.

Contraindications

Hypersensitivity, decompensated heart failure, acute myocardial infarction, unstable angina, pregnancy, childhood.

Side effects

Often (more than 1%):  headache, hot flashes, peripheral edema.

Sometimes (0.1-1%):  tachycardia, palpitations, fatigue, dizziness, paresthesia, nausea, rash, itching.

Rare (0.01-0.1%):  fainting, vomiting, arthralgia, myalgia, sexual disorders, impotence, urticaria.

Very rare (less than 0.01%):  gum hyperplasia, increased liver enzymes, photosensitization, pollakiuria, allergic reactions (fever, angioedema).

Interaction

Biotransformation inhibitors (cimetidine) increase plasma concentrations, stimulants (phenytoin, carbamazepine, barbiturates) – reduce it.

How to take, course of use and dosage

Inside, tablets are recommended to be taken in the morning, washed down with water. Tablets should not be broken, crumbled or chewed. The drug can be taken on an empty stomach or after a light breakfast that does not contain a large amount of fat or carbohydrates.

There are no data on the use of felodipine in children.

Arterial hypertension. The dose should be selected individually. The initial dose is 5 mg once a day. If necessary, the dose may be increased or another antihypertensive drug may be added. The usual maintenance dose of Plendil is 5 to 10 mg once a day. In elderly patients, the possibility of starting treatment with a daily dose of 2.5 mg should be considered.

Angina pectoris. The dose should be selected individually. The initial dose is 5 mg once a day, if necessary, increase the dose to 10 mg once a day.

Overdose

Symptoms:  severe hypotension, bradycardia.

Treatment:  transfer of the patient to the supine position; symptomatic therapy — atropine (iv 0.5-1 mg), alpha_-1-adrenomimetics, glucose, saline solution or dextran by infusion.

Composition

Tablet Form of production

Storage conditions

At temperatures below 30 °C.

Shelf life

3 years

Active ingredient

Felodipine

Conditions of release from pharmacies

By prescription

Dosage form

long-acting tablets

Description

For adults as directed by your doctor

Indications

Hypertension, Angina