Polydex, ear drops, 10.5ml

Composition

Per 100 ml

Active ingredients:  

Neomycin sulfate is 1 g, which corresponds to 650,000 ME.

Polymyxin To 1 000 000ME sulfate.

Dexamethasone sodium metasulfobenzoate 0.100 g

Auxiliary substances:

thiomersal,

citric acid,

1N sodium hydroxide solution,

macrogol 400,

polysorbate 80,

purified water q. s. up to 100 ml

Pharmacological action

Combined drug for topical use in otolaryngology.

The therapeutic effect of Polydex is due to the anti-inflammatory effect of dexamethasone and the antibacterial effect of the antibiotics neomycin and polymyxin B.

The combination of these antibiotics expands the spectrum of antibacterial action on most gram-positive and gram-negative microorganisms that cause infectious and inflammatory diseases of the outer and middle ear.

Neomycin is active against Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, and Haemophilus influenzae.

Polymyxin B is active against gram-negative bacteria: Escherichia coli, Klebsiella pneumoniae, Haemophilus influenzae, Pseudomonas aeruginosa.

Streptococcus spp. is resistant to these antibiotics. (including Streptococcus pneumoniae).

Indications

-Otitis externa without damage to the eardrum;

– infected eczema of the external auditory canal.

Use during pregnancy and lactation

With long-term treatment of pregnant women, there is a risk of ototoxic effects on the fetus.

Contraindications

• infectious or traumatic injuries of the eardrum;
• hypersensitivity to the components of the drug;
• suspicion of angle-closure glaucoma;
• simultaneous use of MAO inhibitors;
• kidney diseases accompanied by albuminuria;
• pregnancy;
• lactation (breastfeeding);
• children under 2.5 years of age.

Side effects

Possible allergic reactions, rarely-skin manifestations.

If the integrity of the eardrum is violated, there is a risk of toxic effects on the auditory and vestibular apparatus.

Interaction

Incompatible with monomycin, streptomycin, gentamicin, amikacin, netilmycin (increased ototoxic effect).

How to take, course of use and dosage

Adults: instill 1-5 drops in each ear 2 times a day for 6-10 days.

Children: instill 1-2 drops in each ear 2 times a day for 6-10 days. Duration of treatment-should not exceed -10 days.

Before using ear drops, it is recommended to warm the bottle by holding it in your hand, in order to avoid unpleasant sensations associated with the ingress of cold liquid into the ear.

After instilling the drug in one ear, tilt your head in the opposite direction for a few minutes, and then drop it in the other ear.

Overdose

Due to the low degree of absorption into the systemic circulation, overdose is unlikely.

Special instructions

Do not inject under pressure.

Concomitant use of other aminoglycosides is not allowed.

With topical application of neomycin or polymyxin B, the development of an allergic reaction may exclude the possibility of systemic use of other antibiotics that are similar in structure to neomycin and polymyxin B.

If you are allergic to neomycin, you may be cross-allergic to antibiotics – aminoglycosides.

Form of production

ear drops

Storage conditions

At a temperature not exceeding 25 °C

Shelf life

3 years

Active ingredient

Dexamethasone, Neomycin, Polymyxin B

Conditions of release from pharmacies

By prescription

Dosage form

ear drops

Description

For Adults by doctor’s prescription, For Adults, For Children by doctor’s prescription

Indications

Otitis