Postinor, pills 0.75mg, 2pcs

Composition

Active ingredient:

levonorgestrel 0.75 mg;

Auxiliary substances:  

colloidal silicon dioxide-0.5 mg;

magnesium stearate-1 mg;

talc-2.5 mg;

corn starch-23.5 mg;

potato starch-0.5 mg;

lactose monohydrate-71.25 mg

Pharmacological action

Postinor is a synthetic drug with a contraceptive effect, pronounced progestogenic and anti-estrogenic properties. With the recommended dosage regimen, levonorgestrel suppresses ovulation and fertilization if sexual contact occurred during the pre-ovulatory phase, when the possibility of fertilization is greatest. It can also cause changes in the endometrium that prevent implantation. The drug is not effective if implantation has already occurred.

Effectiveness: with tablets Postinor can prevent pregnancy in approximately 85% of cases. The more time elapsed between sexual intercourse and taking the drug, the lower its effectiveness (95% during the first 24 hours,85% – from 24 to 48 hours, and 58% – from 48 to 72 hours). Therefore, it is recommended to start taking Postinor tablets as soon as possible (but no later than 72 hours) after sexual contact, if no protective measures have been applied. At the recommended dose, levonorgestrel does not significantly affect blood clotting factors, fat and carbohydrate metabolism.

Pharmacokinetics

With oral use of Postinor, the drug is rapidly and almost completely absorbed. Absolute bioavailability is almost 100% of the dose taken. After taking 0.75 mg of levonorgestrel, the serum Cmax of 14.1 ng / ml is reached in 1.6 hours. After reaching Cmax, the levonorgestrel content decreases. T1 / 2 is about 26 hours.

Levonorgestrel is excreted approximately equally by the kidneys and through the intestines exclusively in the form of metabolites. Levonorgestrel biotransformation corresponds to steroid metabolism. Levonorgestrel is hydroxylated in the liver, and its metabolites are excreted in the form of conjugated glucuronides.

Pharmacologically active metabolites of levonorgestrel are unknown. Levonorgestrel binds to serum albumin and sex hormone-binding globulin (SHBG). Only 1.5% of the total dose is in free form, and 65% is associated with SHBG.

Indications

Emergency (post-coital) contraception (after unprotected sexual contact or unreliability of the method of contraception used).

Contraindications

• adolescents under 16 years of age;
• severe liver failure;
• pregnancy;
• rare hereditary diseases such as lactose intolerance, lactase deficiency or glucose-galactose malabsorption;
• hypersensitivity to the components of the drug.

With caution:  diseases of the liver and biliary tract, jaundice (including in the anamnesis), Crohn’s disease, lactation.

Side effects

Allergic reactions:  possible hives, rash, itching, or swelling of the face.

Transient side effects that occur with varying frequency and do not require medication: sometimes (1-10%) – vomiting, diarrhea, dizziness, headache, breast tenderness, delayed menstruation (no more than 5-7 days; if menstruation is delayed for a longer period, it is necessary to exclude pregnancy); often (more than 10%) – nausea, fatigue, pain in the lower abdomen, acyclic spotting (bleeding).

Interaction

Simultaneous use of drugs that induce liver enzymes accelerates the metabolism of levonorgestrel.

The following drugs may reduce the effectiveness of levonorgestrel: amprecavil, lansoprazole, nevirapine, oxcarbazepine, tacrolimus, topiramate, tretinoin, barbiturates, including primidone, phenytoin and carbamazepine, preparations containing St. John’s wort (Hypericum perforatum), as well as rifampicin, ritonavir, ampicillin, tetracycline, rifabutin, griseofulvin.

Levonorgestrel reduces the effectiveness of hypoglycemic and anticoagulant drugs (coumarin derivatives, phenindione). Increases plasma concentrations of corticosteroids. Women taking these medications should consult a doctor.

Drugs containing levonorgestrel may increase the risk of cyclosporine toxicity due to suppression of its metabolism.

How to take, course of use and dosage

Inside. You should take 2 tablets in the first 72 hours after unprotected sexual intercourse: the 2nd tablet should be taken 12 hours (but not later than 16 hours) after taking the 1st tablet.

To achieve a more reliable effect, both tablets should be taken as soon as possible after unprotected sexual intercourse (no later than 72 hours).

If vomiting occurs within 3 hours after the 1st or 2nd tablet of Postinor, then you should take another 1 tablet.

Postinor can be used at any time of the menstrual cycle. In the case of an irregular menstrual cycle, it is necessary to exclude pregnancy beforehand.

After taking an emergency contraceptive, local barrier contraceptive methods (for example, a condom, a cervical cap) should be used before the next menstrual period. The use of the drug for repeated unprotected sexual intercourse during one menstrual cycle is not recommended (due to an increase in the frequency of acyclic spotting/ bleeding).

Composition

Tablet Form of production

Storage conditions

At a temperature of 15-25 °C

Shelf life

5 years

Active ingredient

Levonorgestrel

Conditions of release from pharmacies

By prescription

Dosage form

Tablets

Description

For women of childbearing age

Indications

Contraception