Potassium chloride bufus Renewal concentrate 4% 10ml ampoules, 10pcs

Composition

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1 ml of solution for intravenous use contains:

Active ingredient:

potassium chloride-40 mg

Pharmacological action

Potassium chloride is a remedy that makes up for the lack of potassium in the body.

Helps maintain the necessary intra-and extracellular potassium levels.

Potassium, the main intracellular ion, plays an important role in regulating various body functions.

It is involved in maintaining intracellular osmotic pressure, in the processes of conducting and transmitting nerve impulses to innervated organs, in skeletal muscle contraction, and in a number of biochemical processes.

Reduces the excitability and conductivity of the myocardium, in high doses – inhibits automatism.

Indications

• Hypokalemia (including on the background of diabetes mellitus, prolonged diarrhea and / or vomiting, therapy with antihypertensive drugs, certain diuretics, glucocorticosteroids),
• treatment and prevention of digital intoxication,
• prevention of arrhythmia in patients with myocardial infarction (in the acute period).

Contraindications

• Hyperkalemia,
• complete atrioventricular block,
• adrenal insufficiency,
• chronic renal failure,
• concomitant therapy with potassium-sparing diuretics,
• metabolic disorders (acidosis, hypovolemia with hyponatremia),
• pregnancy,
• lactation,
• age up to 18 years (efficacy and safety have not been established).

Side effects

Nervous system disorders: paresthesia, muscle weakness, confusion.

From the cardiovascular system: low blood pressure, arrhythmias, heart block, cardiac arrest.

Other: hyperkalemia, allergic reactions.

Interaction

Pharmacologically compatible with cardiac glycoside solutions (improves their tolerability).

Increases the negative dromo – and bathotropic effect of antiarrhythmic drugs.

As part of a polarizing mixture (in combination with dextrose and insulin), it helps to normalize the heart rate in cases of myocardial infarction, ectopic arrhythmias and overdose with cardiac glycosides.

Eliminates gynokalemia caused by glucocorticosteroids, mineralocorticosteroids and diuretics.

Beta-blockers, cyclosporine, potassium-sparing diuretics, heparin, angiotensin converting enzyme inhibitors, and nonsteroidal anti-inflammatory drugs may increase the risk of hyperkalemia.

How to take, course of use and dosage

Intravenously. In case of hypokalemia with cardiac arrhythmia-1-1.5 g 4-5 times a day; after restoring the heart rate, the dose is reduced.

With digitalis intoxication-2-3 g / day, in severe cases-up to 5 g. To stop attacks of paroxysmal tachycardia on the first day – 8-12 g, followed by a decrease to 3-6 g. Intravenously jet, if necessary intravenously drip (slowly, for 1 hour) – 2-2.5 g in 500 ml of 5% dextrose solution.

For the prevention and treatment of ectopic arrhythmias in myocardial infarction-a polarizing mixture: a solution of potassium chloride in 5% – 10% dextrose solution (add insulin at the rate of 1 UNIT per 3-4 g of dry dextrose).

Overdose

Symptoms: hyperkalemia (muscle hypotension, paresthesia of the extremities, slowing of atrioventricular conduction, arrhythmias, cardiac arrest).

Early clinical signs of hyperkalemia usually appear when serum K+ concentrations exceed 6 mEq / L; T wave sharpness, U wave disappearance, ST segment reduction, QT interval prolongation, QRS complex expansion. More severe symptoms of hyperkalemia – muscle paralysis and cardiac arrest-develop at a concentration of K+ 9-10 meq/l.

Treatment: oral or intravenous – NaCl solution; intravenous-300-500 ml of 5% dextrose solution (with 10-20 units of insulin in 1 liter); if necessary – hemodialysis and peritoneal dialysis.

Special instructions

During treatment, it is necessary to monitor the content of K+ in the blood serum, ECG, in the treatment of hypokalemia – control of the acid-base state.

The safety and efficacy of potassium chloride in children have not been established.

If necessary, use during pregnancy should compare the expected benefit to the mother and the potential risk to the fetus. During lactation, you should decide whether to stop breastfeeding.

A diet high in sodium chloride increases the elimination of K+ from the body. It should be borne in mind that hyperkalemia, which leads to a fatal outcome, can develop quickly and be asymptomatic.

Form of production

Solution for intravenous use.

Storage conditions

Store in a dry place protected from light at a temperature of 0 to +30 °C.

Shelf

life is 3 years. Do not use after the expiration date.

Active ingredient

Potassium Chloride

Conditions of release from pharmacies

By prescription

Dosage form

infusion solution