Composition
Each film-coated tablet contains:
- Active ingredient:
- Â Losartan potassium – 50 mg
- Auxiliary substances: Â dried starch, microcrystalline cellulose, purified talc, colloidal silicon dioxide (aerosil-200), sodium starch glycolate (primogel), magnesium stearate, isopropyl alcohol, methylene chloride, Opadry OY – 55030, red dye 4R Lake of Ponceau.
Pharmacological action
Pharmacodynamics
Losartan is a specific angiotensin II (AT1) receptor antagonist. It does not inhibit kinase II, an enzyme that destroys bradykinin.
Reduces total peripheral vascular resistance, reduces afterload, and lowers systemic blood pressure. Lowers blood pressure in the small circle of blood circulation
Pharmacokinetics
Losartan is well absorbed in the gastrointestinal tract after oral use and undergoes initial metabolism during primary passage through the liver.
The bioavailability of losartan is about 33%. The drug does not accumulate in the body.
The half-life of losartan is 2 hours. Both losartan and its metabolite are highly bound to plasma proteins 92-99%. Losartan is excreted in the urine and bile.
Indications
- Arterial hypertension;
- congestive heart failure (as part of combination therapy, in case of intolerance or failure of therapy with ACE inhibitors);
- the reduction in the risk of stroke in patients with hypertension and left ventricular hypertrophy;
- protection of renal function in patients with diabetes mellitus type 2 with proteinuria with the aim of reducing proteinuria, reduce the progression of kidney damage, reduce the risk of end-stage (to prevent the need for dialysis, the probability of an increase in creatinine in the blood serum).
Contraindications
Hypersensitivity, pregnancy, breast-feeding.
Side effects
Nervous system and sensory disorders: Â dizziness, asthenia / fatigue, headache, insomnia; restlessness, sleep disturbance, drowsiness, memory disorders, peripheral neuropathies, paresthesia, hypesthesia, migraine, tremor, ataxia, depression, syncope, tinnitus, taste disorders, vision changes, conjunctivitis.
Respiratory system disorders: Â nasal congestion, cough, upper respiratory tract infections (fever, sore throat, etc. ), sinusopathy, sinusitis, pharyngitis; dyspnoea, bronchitis, rhinitis.
From the digestive tract: Â nausea, diarrhea, dyspeptic symptoms, abdominal pain; anorexia, dry mouth, toothache, vomiting, flatulence, gastritis, constipation.
From the musculoskeletal system: Â cramps, myalgia, back pain, chest pain, leg pain; arthralgia, shoulder pain, knee pain, arthritis, fibromyalgia.
Cardiovascular and blood disorders (hematopoiesis, hemostasis): Â orthostatic reactions (dose-dependent), hypotension, palpitation, tachy – or bradycardia, arrhythmias, angina pectoris, anemia.
From the genitourinary system: Â urgent urge to urinate, urinary tract infections, impaired kidney function, decreased libido, impotence.
From the side of the skin: Â dry skin, erythema, flushing, photosensitization, increased sweating, alopecia.
Allergic reactions: Â urticaria, rash, pruritus, angioedema, including the face, lips, pharynx, and / or tongue.
Other services: Â hyperkalemia; fever, gout, increased levels of hepatic transaminases and bilirubin in the blood.
How to take, course of use and dosage
With arterial hypertension, the initial daily dose is 25 mg, the average daily dose is 50 mg, the frequency of use is 1 time per day.
The maximum hypotensive effect develops in 3-6 weeks after the start of taking the drug. If necessary, the dose of the drug can be increased to 100 mg per day. In this case, you can take the drug 2 times a day.
The initial dose for patients with heart failure is 12.5 mg once a day. As a rule, the dose is titrated at weekly intervals (i. e. 12.5 mg / day,25 mg/ day,50 mg/day). up to an average maintenance dose of 50 mg once a day, depending on the patient’s tolerance to the drug.
When prescribing the drug to patients receiving high doses of diuretics, the initial dose should be reduced to 25 mg once a day.
Patients with hepatic impairment should be given lower doses of losartan.
In elderly patients, as well as patients with impaired renal function, including patients on hemodialysis, there is no need to adjust the initial dose of the drug.
Prezartan can be co-administered with other antihypertensive medications. Losartan can be used regardless of food intake.
Composition
Tablet Form of production
Storage conditions
Store in a dry place, protected from light, at a temperature not exceeding 25 °C
Shelf life
3 years
Active ingredient
Losartan
Conditions of release from pharmacies
By prescription
Dosage form
Tablets
Description
For adults as directed by your doctor
Indications
Prevention of heart attacks and strokes, Heart failure, Hypertension, Diabetic nephropathy
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Side effects of Presartan, pills 50mg, 30pcs.
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