Progesterone, olive oil solution 2.5%, 1ml, 10pcs

Composition

1 ampoule with 1 ml of solution for injection in olive or peach oil contains 0.01 g of progesterone.

Pharmacological action

Progesterone is a progestogen. Yellow body hormone. Causes the transition of the uterine mucosa from the proliferation phase caused by follicular hormone to the secretory phase, and after fertilization contributes to its transition to the state necessary for the development of a fertilized egg.

Reduces excitability and contractility of the uterine and fallopian tube muscles, stimulates the development of the terminal elements of the breast. It has no androgenic activity.

Progesterone has a weak effect on protein metabolism, promotes fat deposition and glucose accumulation in the liver, and also reduces sodium reabsorption in the renal tubules.

Progesterone has a blocking effect on the secretion of hypothalamic LH and FSH release factors, inhibits the formation of gonadotropin hormones in the pituitary gland and inhibits ovulation.

Pharmacokinetics

After intravenous injection, it is absorbed quickly and almost completely. It is metabolized in the liver, and most of its metabolites form conjugates with glucuronic and sulfuric acids.

T1 / 2 of plasma is a few minutes. It is excreted in the urine-50-60% and with feces-more than 10%. The amount of metabolites that are excreted in the urine varies depending on the phase of the corpus luteum.

Indications

Dysfunctional uterine bleeding, metrorrhagia, amenorrhea, habitual miscarriage.

Contraception.

Contraindications

Severe liver or kidney dysfunction, hepatitis, thromboembolic diseases, vaginal bleeding of unknown origin, breast carcinoma (except in cases where progesterone is used as part of the combination therapy of this disease).

Side effects

From the cardiovascular system:  increased blood pressure.

From the side of metabolism:  edema.

From the digestive system:  liver function disorders, jaundice; rarely (with prolonged use) – nausea, vomiting.

From the endocrine system:  rarely ( with prolonged use) – decreased libido, weight gain, pain and tension in the mammary glands, irregular uterine bleeding.

From the central nervous system:  rarely ( with prolonged use) – headache, depression.

Interaction

Reduces the intensity of action of drugs that stimulate the smooth muscles of the uterus, anabolic steroids, gonadotropic hormones of the anterior pituitary gland.

Reduces the lactogenic effect of oxytocin.

Increases the effect of diuretics, antihypertensive drugs, and immunosuppressants.

When used concomitantly with barbiturates, a decrease in the effect of progesterone is noted.

How to take, course of use and dosage

The dosage regimen is individual.

The dose, frequency and duration of treatment are determined according to the scheme, depending on the indications and clinical situation.

Product form

solution for injection

Storage conditions

Store in a dark place, in tightly closed packaging, at a temperature not exceeding 30 °C

Shelf life

5 years

Active ingredient

Progesterone

Conditions of release from pharmacies

By prescription

Dosage form

solution for injection

Description

Nursing mothers as prescribed by a doctor, Adults as prescribed by a doctor, Pregnant women in the first trimester as prescribed by a doctor

Indications

Infertility Treatment, Menstrual Disorders, Bleeding, Threatened Miscarriage