Proserine, ampoules 0.05%, 1ml, 10pcs

Composition

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1 ml of the solution contains:

Active ingredient:  

neostigmine methylsulfate-500 mcg

Pharmacological action

Pharmacological action

Inhibitor of acetylcholinesterase and pseudocholinesterase. It has an indirect cholinomimetic effect due to reversible inhibition of cholinesterase and potentiation of the action of endogenous acetylcholine.

Improves neuromuscular transmission, enhances gastrointestinal motility, increases the tone of the bladder, bronchi, and secretion of exocrine glands. Causes bradycardia, lowering blood pressure. Narrows the pupil, lowers intraocular pressure, causes a spasm of accommodation.

Pharmacokinetics

After parenteral use of neostigmine, methyl sulfate undergoes hydrolysis and is also metabolized in the liver to form inactive metabolites. Binding to plasma proteins is 15-25%.

It is excreted in the urine (80% within 24 hours) as an unchanged substance (about 50%) and metabolites. Poorly penetrates the BBB.

Indications

• for myasthenia gravis (muscle weakness)
• poliomyelitis
• glaucoma
• decreased tone of the stomach, intestines and bladder.

Contraindications

• epilepsy,
• bronchial asthma,
• angina pectoris,
• atherosclerosis,
• prostate adenoma,
• peptic ulcer of the stomach and duodenum,
• hypersensitivity to the drug.

Side effects

• nausea,
• vomiting,
• diarrhea
• decreased pulse,
• decreased blood pressure
• twitching of the muscles of the tongue and skeletal muscles
• allergic reactions.

Interaction

Neostigmine methylsulfate is an antagonist of non-depolarizing muscle relaxants and increases the effect of depolarizing muscle relaxants when used concomitantly.

Concomitant use of m-holinoblockers, ganglioblockers, quinidine, novocainamide, local anesthetics, tricyclic antidepressants, antiepileptic and antiparkinsonian agents reduces the effect of neostigmine methylsulfate.

Ephedrine potentiates the action of neostigmine methyl sulfate.

Concomitant use of neostigmine methylsulfate with beta-blockers may increase bradycardia.

How to take, course of use and dosage

Solution for adults Proserin is administered subcutaneously-1-2 mg 1-2 times / day.

Children are given Proserin subcutaneously, the dose is calculated at 50 mcg for 1 year of life, but not more than 375 mcg per injection.

Overdose

Symptoms: associated with overexcitation of cholinergic receptors( cholinergic crisis): bradycardia, hypersalivation, miosis, bronchospasm, nausea, increased peristalsis, diarrhea, increased urination, twitching of the tongue and skeletal muscles, gradual development of general weakness, decreased blood pressure (BP).

Treatment:  reduce the dose or stop treatment, if necessary, enter atropine (1 ml of 0.1% solution), metacin, etc. holinoblokiruyushchy preparations.

Special instructions

Use with caution in Addison’s disease.

When parenterally administered in high doses, preliminary or simultaneous use of atropine is necessary.

If a myasthenic (due to insufficient therapeutic dose) or cholinergic (due to overdose) crisis occurs during therapy, careful differential diagnosis is required due to the similarity of symptoms.

Influence on the ability to drive motor vehicles and manage mechanisms

During the treatment period, you should refrain from driving vehicles and other potentially dangerous activities that require concentration of attention and a high rate of psychomotor reactions.

Form of production

Solution for injection.

Storage conditions

Store in a dry place, protected from children.

Active ingredient

Neostigmine Methyl Sulfate

Conditions of release from pharmacies

By prescription

Dosage form

solution for injection