Protargol-LOR pills for preparation of solution for local use 200mg complete bottle, cap-pipette, 2pcs

Composition

Composition per tablet: Active ingredient: silver proteinate (protargol) – 200.0 mg. Excipient: hydroxypropylmethylcellulose-10.0 mg

Pharmacological action

Pharmacotherapeutic group: Antiseptic agent

ATX Code: D08AL

Pharmacological properties

Pharmacodynamics

When ingested, silver proteinate dissociates to form silver ions, which have an astringent, antiseptic, and anti-inflammatory effect. Silver ions actively inhibit the reproduction of infectious agents by binding their DNA. The mechanism of action of protargol is based on the fact that silver ions deposit proteins on the damaged mucous membrane and form a protective film. At the same time, sensitivity decreases, blood vessels narrow (this leads to a decrease in edema) and the inflammatory process is suppressed. Silver ions also inhibit the growth of various bacteria. Active against gram-positive and gram-negative bacteria: B. cereus, C. albicans, E. coli, P. aeruginosa, C. aureus, A. niger, S. abony, etc.

When applied topically, it is practically not absorbed.

Indications

Symptomatic treatment of acute nasopharyngitis (runny nose), sinusitis.

Use during pregnancy and lactation

It is contraindicated to use the drug during pregnancy and lactation

Contraindications

Hypersensitivity to the components of the drug, atrophic rhinitis, pregnancy, breastfeeding, children under 3 years of age (for this dosage).

Side effects

-allergic reactions: itching of the skin, irritation of the mucous membrane, urticaria; – burning sensation and numbness; – dry mouth; – redness of the eyes; – anaphylactic shock; – angioedema;- atopic dermatitis.

Interaction

Pharmacodynamic, pharmacokinetic interaction: not studied. Pharmaceutical interaction: zinc, copper, lead, silver, mercury, iron, and aluminum salts form insoluble precipitates with silver proteinate solution; silver proteinate solution is inactivated by alkaloid salts and organic bases (epinephrine).

How to take, course of use and dosage

Topically in the form of a 2% solution. Method of preparation of 2% solution: 1. Place one Protargol-ENT tablet in a dark glass bottle. 2. Pour 10 ml of boiled water (previously cooled to room temperature) or water for injection into the bottle (up to the level of the “shoulders” – narrowing of the bottle).3. Close the bottle with a pipette cap, shake vigorously for 5 minutes, then leave for 10 minutes and then shake vigorously again for 5 minutes. The tablet should dissolve completely. The finished solution should be stored for no more than 30 days in a place protected from light at a temperature not exceeding 25°C. Before using Protargol-ENT, it is recommended to wash and clean the nasal passages. Adults and children over 6 years of age,2-3 drops in each nasal passage 3 times a day. Children from 3 to 6 years: 1-2 drops in each nasal passage 3 times a day for 5-7 days. The main effect of the drug will appear only 2-3 days after the first use. If symptoms persist or worsen for more than 5-7 days, it is recommended to consult a doctor. Use the drug only according to the method of application and in the doses indicated in the instructions for use. If necessary, please consult your doctor before using the medicine.

Overdose

Symptoms: with the recommended method of use, overdose is unlikely. Possible increased side effects. If you accidentally swallow a large amount of the drug, irritation of the gastrointestinal tract may occur. With prolonged uncontrolled use of the drug, it is theoretically possible to develop a very rare disease – argyrosis (staining in gray or bluish color of the skin and mucous membranes). If the recommended dosage regimen is followed, the risk of argyrosis is unlikely. Treatment: in case of severe irritation, burning, itching of the eyes, skin, mucous membranes, rinse with plenty of water for 15 minutes. Treatment is symptomatic.

Description

Round flat-cylindrical tablets from brown to dark brown or almost black in color with a bluish tinge with uneven surface color, with a chamfer and risk

Special instructions

It is possible to stain the discharge from the nose in gray or blue. Please read the instructions for use carefully before using the product. Save the instructions, you may need them again. If you have any questions, contact your doctor. The medicine you are being treated with is intended for you personally, and it should not be passed on to others, as it can cause harm to them even if you have the same symptoms as you do. The effect of the drug on the ability to drive vehicles, mechanisms and mechanisms The drug does not affect the ability to drive vehicles or engage in other potentially dangerous activities that require increased concentration of attention and speed of psychomotor reactions.

Form of production

Tablets for preparation of a solution for topical application,200 mg.

Storage conditions

In the original packaging at a temperature not exceeding 25 ° C. The finished solution is stored in a dark place at a temperature not exceeding 25 ° C. Keep out of reach of children

Shelf

life is 2 years. Ready solution – 30 days. Do not use after the expiration date indicated on the package

Active ingredient

Silver Proteinate