Pyrogenal, ampoules 25 µg, 1ml, 10pcs

Composition

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1 ml contains:

Active community:

bacterial lipopolysaccharide for intramuscular use of 25 mcg.

Pharmacological action

Pyrogenal is a broad-spectrum immunomodulator, the main of which are the activation of the reticuloendothelial, hypothalamic-pituitary and fibrinolytic systems. Pyrogenal has adjuvant, desensitizing and anti-inflammatory properties, increases the general and specific resistance of the body, affects the thermoregulatory centers of the hypothalamus.

The drug, stimulating cells of the phagocytic system, activates phagocytosis, the secretion of oxygen radicals, the synthesis of interleukin – 1 (IL-1, IL-2), tumor necrosis factor (TNF_-L), interferon (IFN_-L). Acting on fibroblasts, it prevents the synthesis of collagen by fibroblasts, accelerates the process of maturation of fibrocytes.

It stimulates the activity of hyaluronidase: it increases the permeability of tissues, improves the fibrinolytic properties of blood, restores blood circulation, prevents the formation of new and resolves previously formed dense scars and adhesions, prevents vascular obliteration, and stimulates tissue regeneration and epithelialization.

Activates the function of the adrenal cortex: it has an anti-inflammatory effect, increases the concentration of hormones in the blood. It stimulates the kinin system.

Indications

The drug is intended for non-specific therapy:

• Chronic liver diseases.
• Strictures of the urethra and ureters.
• Chronic prostatitis and urethritis.
• Inflammatory processes of the uterine appendages.
• Adhesive disease of the abdominal cavity.
• Burn disease.
• Venereal diseases.

The drug is used for immunoprophylaxis and immunorehabilitation in case of incomplete recovery after acute bacterial and viral diseases.

Use during pregnancy and lactation

Contraindicated in pregnancy. Breast-feeding should be discontinued for the duration of treatment.

Contraindications

Pyrogenal should not be administered:

• Patients suffering from acute febrile diseases.
• Pregnant women.
• people with individual intolerance to the drug.

Compensated forms of diseases of the cardiovascular system and diabetes are not contraindications to the use of suppositories.

Interaction

The drug is compatible and well combined with all drugs used in the treatment of diseases and conditions indicated in the indications. Increases the effectiveness of chemotherapeutic drugs as part of complex therapy.

How to take, course of use and dosage

I / M,1 time per day. Injections are made every other day. If necessary, dilute with 0.9% sodium chloride solution for injection. The drug in the opened ampoule is not subject to storage.

The initial single dose is 2.5 mcg. In the following days, the dose is gradually increased by 2.5-5 mcg. The maximum single dose is 100 mcg. The full course is from 10 to 30 injections. If necessary, the injection courses are repeated at least in 2-3 months.

When prescribing pyrogenal for pyrotherapy, the drug is administered intravenously 1 time a day, starting from 10-25 mcg, with a gradual increase in the dose to 100-150 mcg. Injections are made after 1 or 2 days as prescribed by a doctor. As prescribed by the doctor, it is also possible to combine the use of intravenous injections with the introduction of suppositories.

Form of production

Solution for intravenous use

Storage conditions

Store in a dry place, protected from light, at a temperature of 2-10 °C

Shelf life

2 years

Active ingredient

Bacterial lipopolysaccharide

Conditions of release from pharmacies

By prescription

Dosage form

solution for injection

Description

For adults by doctor’s prescription, Children by doctor’s prescription