ATC code | C10AA07 |
---|---|
CAS Number | 1254451-40-7 |
Other product names | Evolocumab |
Dosage form | Solution for injection, single-dose prefilled syringe, single-dose prefilled autoinjector, single-dose on-body infusor with prefilled cartridge |
Active ingredient | Evolocumab |
Other ingredients | Proline, glacial acetic acid, polysorbate 80, sucrose, sodium chloride, water for injections |
Pharmacological classification | PCSK9 inhibitors |
Pharmacological action | Reduces low-density lipoprotein cholesterol (LDL-C) levels, reduces the risk of cardiovascular events |
Storage conditions | Refrigerate (35°F to 46°F) until ready to use. Can be stored at room temperature (68°F to 77°F) in the original box for up to 30 days. |
What is Repatha?
Prescription medication Repatha is used to decrease blood low-density lipoprotein (LDL) cholesterol, sometimes referred to as bad cholesterol. Acting by attaching to PCSK9, a protein that prevents LDL receptor recycling, this monoclonal antibody is Repatha binds to PCSK9 to boost LDL receptor count on the surface of liver cells, therefore facilitating absorption and LDL cholesterol clearance from the circulation.
Repatha Composition
Active ingredient of repatha is evolocumab. It comes in several dose forms:
- Pre-filled syringe: Repatha 140 mg solution for injection One milliliter of pre-filled syringe has 140 mg of evolocumab in 1 mL of solution.
- Pre-filled pen: Repatha 140 mg solution for injection One milliliter of pre-filled pen has 140 mg of evolocumab.
- Repatha 420 mg solution for injection in a cartridge: Every cartridge has 420 milligrams of evolocumab in 3.5 mL of solution (120 mg/mL).
Repatha Benefits and Effects
In adults with cardiovascular disease, repatha mostly helps to lower LDL cholesterol levels and lower the risk of heart attack, stroke, and several kinds of heart surgery. In people with high blood cholesterol levels known as primary hyperlipidemia—including homozygous and familial heterozygous hypercholesterolemia—it is also utilized in One can use repatha either on its own or in combination with other medications decreasing cholesterol.
Repatha is licensed to lessen the risk of heart attack or stroke and to minimize the need for some cardiac operations in adults with heart disease. In adults with primary hyperlipidemia—including familial heterozygous and homozygous hypercholesterolemia—it is also used to decrease elevated cholesterol levels.
How to Use Repatha
Repatha is given under the skin by subcutaneous injection, so it is Usually, one takes either 420 mg by subcutaneous injection once a month or 140 mg by subcutaneous injection every two weeks. Your doctor will decide the particular frequency and dosage depending on your particular need.
Repatha Dosage and Administration
Repatha has a dosage and administration as follows:
- Every two weeks, subcutaneous injection of 140 mg repatha.
- Once a month, subcutaneous injection of Repatha 420 mg.
Using either the single-dose on-body infusor with prefilled cartridge or the single-dose prefilled autoinjector or single-dose prefilled syringe, the 420 mg dose of Repatha can be given over five minutes either consecutively using three injections consecutively within 30 minutes or over five minutes.
Repatha Side Effects
Although not everyone has adverse effects from Repatha, like all medications it might have them. Typical adverse effects of Repatha include redness, discomfort, or bruising at the injection site.
- Back discomfort
- Flu-like illnesses
Repatha seldom causes more severe adverse effects. You should get right back to your doctor if you have any odd or severe side effects.
Repatha Contraindications
Not everyone will find repatha appropriate. Those allergic to evolocumab or any other component in Repatha should not take it. Tell your doctor whether you have any other medical conditions as well; these include:
- Liver disease
- kidney disorders
- Nursing or pregnancy
Your doctor will be able to guide you regarding whether Repatha is suitable and safe for you.
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Side effects of Repatha solution 140mg/ml 1ml syringe pens, 1pc
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