Rimantadine pills 50mg, 20pcs

Composition

Active ingredient: rimantadine hydrochloride-50.0 mg. Excipients: lactose monohydrate-74.50 mg, potato starch-22.57 mg, talc-1.50 mg, calcium stearate-1.43 mg

Pharmacological action

Pharmacotherapeutic group: Antiviral agent. ATX Code: J05AC02 Pharmacological Properties:

Pharmacodynamicarimantadine is an antiviral agent derived from adamantane; it is active against various strains of influenza A virus (especially type 2 A). Being a weak base, Rimantadine acts by increasing the pH of endosomes, which have a membrane of vacuoles that surround viral particles after they enter the cell. Preventing acidification in these vacuoles blocks the fusion of the viral envelope with the endosome membrane, thus preventing the transfer of viral genetic material to the cytoplasm of the cell. The drug Rimantadine also inhibits the release of viral particles from the cell, i. e. interrupts the transcription of the viral genome.

Pharmacokineticsafter oral use, Rimantadine is almost completely absorbed in the intestine. Absorption is slow. Binding to plasma proteins is about 40%. Volume of distribution: adults – 17-25 l/kg, children – 289 l/kg. The concentration in the nasal secretions is 50% higher than the plasma one. The maximum concentration of Rimantadine in blood plasma (Cmax) when taking 100 mg once a day is 181 ng / ml,100 mg twice a day is 416 ng/ml. It is metabolized in the liver. The half-life (T 1/2) is 24-36 hours; 15% is excreted unchanged by the kidneys,75-85% – in the form of metabolites. In chronic renal failure, T 1/2 increases by 2 times. In patients with renal insufficiency and in the elderly, toxic concentrations may accumulate if the dose is not corrected in proportion to the decrease in creatinine clearance.

Indications

Early treatment and prevention of influenza A in adults and children over 7 years of age.

Contraindications

• Acute liver diseases,
• acute and chronic kidney diseases,
• thyrotoxicosis,
• hypersensitivity to rimantadine,
• pregnancy and lactation,
• children under 7 years of age,
• with lactase deficiency, lactose intolerance, lactose/isomaltose malabsorption syndrome (since the drug contains lactose).

With caution: in case of arterial hypertension, atherosclerosis of cerebral vessels, liver failure, epilepsy, diseases of the gastrointestinal tract.

Side effects

From the digestive system:  epigastric pain, flatulence, increased bilirubin levels in the blood, dry mouth, anorexia, nausea, vomiting, gastralgia.

From the central nervous system:  headache, insomnia, nervousness, dizziness, impaired concentration, drowsiness, anxiety, increased excitability, fatigue.

Other services:  allergic reactions.

Interaction

When used concomitantly, rimantadine reduces the effectiveness of antiepileptic drugs.

Adsorbents, binders and enveloping agents reduce the absorption of rimantadine.

Drugs that acidify the urine (ammonium chloride, ascorbic acid), reduce the effectiveness of rimantadine (due to increased excretion by the kidneys).

Urine alkalinizing agents (acetazolamide, sodium bicarbonate) increase its effectiveness (reduced renal excretion).

Paracetamol and acetylsalicylic acid reduce the_cmax of rimantadine by 11%.

Cimetidine reduces the clearance of rimantadine by 18%.

How to take, course of use and dosage

Inside (after eating) with water. Flu treatment should be initiated within 24-48 hours after the onset of symptoms. Adults on the first day,100 mg 3 times a day; on the second and third days,100 mg 2 times a day; on the fourth and fifth days,100 mg once a day. On the first day of therapy, it is possible to use the drug once in a dose of 300 mg. The course of treatment is 5 days. Children aged 7 to 10 years-50 mg 2 times a day; from 10 to 14 years-50 mg 3 times a day; older than 14 years-adult doses. The course of treatment is 5 days. For the prevention of influenza: in adults,50 mg once a day for up to 30 days; in children over 7 years of age,50 mg once a day for up to 15 days, depending on the epidemiological situation. If there is no improvement after treatment, or if symptoms worsen or new symptoms appear, you should consult your doctor. Use the drug only according to the indications, the method of use and in the doses indicated in the instructions. You should see your doctor if symptoms worsen or don’t improve after 2-3 days of treatment.

Overdose

Symptoms: agitation, hallucinations, arrhythmia. Treatment: gastric lavage, symptomatic therapy: measures to maintain vital functions. Rimantadine is partially eliminated by hemodialysis.

Special instructions

Rimantadine is used with caution in patients with arterial hypertension, epilepsy (including in the anamnesis), and atherosclerosis of the cerebral vessels.

When using rimantadine, it is possible to exacerbate chronic concomitant diseases. Elderly patients with arterial hypertension have an increased risk of hemorrhagic stroke. If there is a history of epilepsy and previous anticonvulsant therapy, rimantadine increases the risk of developing an epileptic seizure. In such cases, rimantadine is used at a dose of up to 100 mg/day simultaneously with anticonvulsant therapy.

In influenza caused by the B virus, rimantadine has an antitoxic effect.

Preventive treatment is effective in contact with sick people, when the infection spreads in closed groups, and when there is a high risk of developing the disease during an influenza epidemic. Viruses that are resistant to the drug may appear.

Storage conditions

In a dry place, protected from light, at a temperature not exceeding 25 °C. Keep out of reach of children.

Shelf

life is 2 years. Do not use after the expiration date indicated on the package.

Active ingredient

Rimantadine

Dosage form

Tablets