Rimantadine pills 50mg Renewal, 20pcs

Composition

Active ingredient: Rimantadine Hydrochloride-50.0 mgsupport substances: lactose monohydrate-74.5 mg potato starch-24.0 mg magnesium stearate-1.5 mg

Pharmacological action

Rimantadine is an antiviral agent derived from adamantane; it is active against various strains of influenza A virus (especially type 2 A). Being a weak base, rimantadine acts by increasing the pH of endosomes – membrane-bound vacuoles that surround viral particles after they enter the cell. Preventing acidification in these vacuoles blocks the fusion of the viral envelope with the endosome membrane, thus preventing the transfer of viral genetic material to the cytoplasm of the cell. Rimantadine also inhibits the release of viral particles from the cell, i. e. interrupts the transcription of the viral genome. Pharmacokineticsafter oral use, rimantadine is almost completely absorbed in the intestine. Absorption is slow. Binding to plasma proteins is about 40%. Volume of distribution: adults – 17-25 l/kg, children – 289 l/kg. The concentration in nasal secretions is 50% higher than in plasma. The maximum concentration (Cmax) of the Active ingredient in blood plasma after a single dose of 100 mg once a day is reached in 6 hours and is 181 ng / ml, at 100 mg twice a day-416 ng/ml. It is metabolized in the liver. The elimination half-life is 24-36 hours (T 1/2); 75-85% of the dose is mainly excreted by the kidneys in the form of metabolites,15% – unchanged. In chronic renal failure, the half-life is increased by 2 times. In patients with renal insufficiency and in the elderly, toxic concentrations may accumulate if the dose is not corrected in proportion to the decrease in creatinine clearance (CC).

Indications

Early treatment and prevention of influenza A in adults and children over 7 years of age.

Use during pregnancy and lactation

The use of Rimantadine is contraindicated during pregnancy and lactation.

Contraindications

Hypersensitivity to rimantadine or any other component of the drug. Acute liver diseases, acute and chronic kidney diseases, thyrotoxicosis, lactase deficiency, lactose intolerance, glucose-galactose malabsorption, pregnancy, breast-feeding, children under 7 years of age. With caution Arterial hypertension, epilepsy (including in the anamnesis), cerebral vascular atherosclerosis, liver failure, elderly patients, diseases of the gastrointestinal tract.

Side effects

From the cardiovascular system: tachycardia, heart failure, heart block (heart rhythm disorder), palpitation sensation, arterial hypertension, impaired cerebral circulation, loss of consciousness. From the nervous system: insomnia, dizziness, headache, irritability, fatigue, impaired concentration, motor disorders, drowsiness, depressed mood, euphoria, hyperkinesia, tremor, hallucinations, confusion, convulsions. From the side of the senses: tinnitus, change or loss of the sense of smell. From the respiratory system: shortness of breath, bronchospasm, cough. From the gastrointestinal tract: nausea, vomiting, loss of appetite, dryness of the oral mucosa, abdominal pain, diarrhea, dyspepsia. Skin and subcutaneous tissue disorders: rash. Other: fatigue. If you experience any of the side effects listed in the instructions or they get worse, or you notice any other side effects not listed in the instructions, tell your doctor.

Interaction

Rimantadine reduces the effectiveness of antiepileptic drugs. Adsorbents, binders and enveloping agents reduce the absorption of rimantadine. Urine alkalinizing agents (acetazolamide, sodium bicarbonate, etc. ) increase the effectiveness of rimantadine due to a decrease in its excretion by the kidneys. Paracetamol and ascorbic acid reduce the maximum concentration of rimantadine in blood plasma by 11%. Cimetidine reduces rimantadine clearance by 18%. If you are using the above or other medications (including over-the-counter medications), please consult your doctor before using rimantadine.

How to take, course of use and dosage

Rimantadine is taken orally (after a meal), washed down with water. Flu treatment should be started within 24-48 hours after the onset of symptoms. Use in adults: – on the first day of the disease – 100 mg 3 times a day;- on the second and third day of the disease-100 mg 2 times a day; – on the fourth and fifth day of the disease-100 mg 1 time a day. On the first day of therapy, it is possible to use the drug once in a dose of 300 mg. The course of treatment is 5 days. Use in children: – at the age of 7 to 10 years – 50 mg 2 times a day; – at the age of 10-14 years-50 mg 3 times a day; – older than 14 years-adult doses. The course of treatment is 5 days. Flu prevention: – adults: 50 mg once a day for 30 days, depending on the epidemiological situation. – in children over 7 years of age,50 mg once a day for 15 days, depending on the epidemiological situation.

Overdose

Symptoms: agitation, hallucinations, arrhythmia. In some cases, if the recommended dose is exceeded, the following symptoms are observed: eye watering and eye pain, increased urination, fever, constipation, sweating, inflammation of the oral mucosa, dry skin.

Treatment: gastric lavage, symptomatic therapy. In case of poisoning, it is necessary to maintain vital functions. Rimantadine is partially eliminated by hemodialysis.

Special instructions

Viruses that are resistant to the drug may appear. Preventive treatment is effective in contact with sick people, when the infection spreads in closed groups, and when there is a high risk of developing the disease during an influenza epidemic. When using the drug Rimantadine, it is possible to exacerbate chronic concomitant diseases. Elderly patients with arterial hypertension have an increased risk of hemorrhagic stroke. If there is a history of epilepsy and previous anticonvulsant therapy, rimantadine increases the risk of developing a seizure. In such cases, Rimantadine is used at a dose of 100 mg/day simultaneously with anticonvulsant therapy. In influenza caused by the B virus, rimantadine has an antitoxic effect. Effects on the ability to drive vehicles, mechanisms Mirimantadine does not affect the ability to drive a vehicle, but individuals who experience dizziness, headache, or other side effects from the central nervous system should exercise caution.

Storage conditions

In a dry place, protected from light, at a temperature not exceeding 25 °C. Keep out of reach of children.

Shelf

life is 5 years.

Active ingredient

Rimantadine

Dosage form

Tablets