Rinza pills, 10pcs

Product description

It helps to relieve the main symptoms of colds, acute respiratory viral infections and flu, because it contains a complex of active ingredients.

Composition

1 tablet contains: Active ingredients: Caffeine………………………… ……………….30 mgParacetamol………………………………….500 mg Phenylephrine Hydrochloride……………………10 MG of chlorphenamine maleate. ……. ……….. ….. ……..2 mg Auxiliary substances: colloidal silicon dioxide, corn starch, corn starch (for 20% paste), povidone (K 30), sodium methylparahydroxybenzoate, magnesium stearate, talc, sodium carboxymethyl starch (type A), crimson dye [Ponceau 4R].

Pharmacological action

Combined drug.

Paracetamol has analgesic and antipyretic effects. Reduces the pain syndrome associated – sore throat, headache, muscle and joint pain, reduces high fever.

Phenylephrine is an alpha-1-adrenomimetic. It has a vasoconstrictive effect, reduces edema and hyperemia of the mucous membranes of the upper respiratory tract and paranasal sinuses.

Chlorphenamine is a histamine H1-receptor blocker, has an anti-allergic effect, reduces swelling and hyperemia of the nasal mucosa, eliminates itching in the eyes and nose, nasopharynx and paranasal sinuses, reduces exudative manifestations.

Caffeine has a stimulating effect on the central nervous system, which leads to a reduction in fatigue and drowsiness, to increase mental and physical performance.

Indications

Symptomatic treatment of “colds”, acute respiratory viral infections, including flu (fever syndrome, pain syndrome, rhinorrhea).

Use during pregnancy and lactation

Due to the lack of clinical data, the safety of using the drug during pregnancy and lactation has not been established, so the use of the drug in this category of patients is contraindicated.

Contraindications

• severe atherosclerosis of the coronary arteries;
• arterial hypertension;
• portal hypertension;
• diabetes mellitus;
• concomitant use of tricyclic antidepressants, monoamine oxidase inhibitors (MAOIS), beta-blockers;
• hypersensitivity to paracetamol and other components included in the composition of the drug;
• taking other medications containing substances included in the composition of the drug Rinza®;
• pregnancy, lactation;
• children’s age (under 15 years);
• alcoholism.

Side effects

Allergic reactions: skin rash, pruritus, urticaria, angioedema, anaphylactic shock. From the nervous system: headache, dizziness, drowsiness, sleep disturbance, increased excitability. From the cardiovascular system: increased blood pressure, tachycardia, palpitation sensation. From the digestive system: nausea, vomiting, epigastric pain, diarrhea, dryness of the oral mucosa, hepatotoxic effect. From the sensory organs: mydriasis, paresis of accommodation, increased intraocular pressure. Hematopoietic disorders: anemia, thrombocytopenia, agranulocytosis, hemolytic anemia, aplastic anemia, methemoglobinemia, pancytopenia, leukopenia. From the urinary system: nephrotoxicity (renal colic, glucosuria, interstitial nephritis, papillary necrosis), difficulty urinating. Other: bronchospasm. Serious skin reactions: Very rare: – Acute generalized exanthematous pustulosis (OGEP). Acute condition with the development of pustular rashes. It is characterized by fever and diffuse erythema accompanied by burning and itching. There may be swelling of the face, hands and mucous membranes; – Stevens-Johnson syndrome (SSD) (malignant exudative erythema). Severe form of erythema multiforme, in which blisters appear on the mucous membrane of the mouth, throat, eyes, genitals, and other areas of the skin and mucous membranes. – Toxic epidermal necrolysis (TEN, Lyell’s syndrome). The syndrome is a consequence of extensive apoptosis of keratinocytes, which leads to the detachment of large areas of the skin at the sites of the dermoepidermal junction. The affected skin has the appearance of scalded with boiling water. If you notice any of the side effects described above, you should stop taking the drug and immediately consult a doctor!

Interaction

Increases the effects of monoamine oxidase (MAO) inhibitors, sedatives, and ethanol. Antidepressants, antiparkinsonian drugs, antipsychotics, and phenothiazine derivatives increase the risk of urinary retention, dry mouth, and constipation. Glucocorticosteroids increase the risk of glaucoma. Microsomal oxidation inhibitors (cimetidine) reduce the risk of hepatotoxic effects. Metoclopramide and domperidone increase, and colestyramine reduces the rate of absorption of paracetamol. Paracetamol reduces the effectiveness of uricosuric drugs. When administered concomitantly with barbiturates, diphenine, carbamazepine, rifampicin isoniazid, zidovudine and other inducers of microsomal liver enzymes, the risk of developing hepatotoxic effects of paracetamol increases. With the combined use of chloramphenicol and paracetamol, the half-life of chloramphenicol may increase. In most patients taking warfarin for a long time, the infrequent use of paracetamol usually has little or no effect on the international normalized ratio (INR). However, with prolonged regular use, paracetamol increases the effect of indirect anticoagulants (warfarin and other coumarin derivatives), which increases the risk of bleeding. A single high dose of caffeine increases the excretion of lithium by the kidneys. Abrupt discontinuation of caffeine can lead to an increase in the concentration of lithium in the blood serum. Chlorphenamine simultaneously with monoamine oxidase (MAO) inhibitors, furazolidone can lead to a hypertensive crisis, agitation, and hyperpyrexia. Concomitant use of phenylephrine with digoxin and other cardiac glycosides may increase the risk of arrhythmia and myocardial infarction. Phenylephrine, when taken with MAO inhibitors, can lead to an increase in blood pressure. Phenylephrine reduces the effectiveness of beta-blockers and antihypertensive drugs. Tricyclic antidepressants enhance the adrenomimetic effect of phenylephrine, while concomitant use of halothane increases the risk of ventricular arrhythmia. Reduces the hypotensive effect of guanethidine, which, in turn, increases the alpha-adrenomimetic activity of phenylephrine.

How to take, course of use and dosage

Inside. Children over 15 years of age and adults – 1 tablet 3-4 times a day. The maximum daily dose is 4 tablets. The course of treatment is not more than 5 days.

Overdose

In case of overdose, you should immediately consult a doctor. Getting medical attention quickly is critical, even if you don’t see any signs or symptoms.

• Caffeine

Symptoms of acute overdose: abdominal pain, vomiting, flushing of blood to the face, fever, chills, agitation, insomnia, irritability, loss of appetite, weakness, tremor, increased muscle tone, altered state of consciousness, delirium, hallucinations, increased blood pressure followed by hypotension, tachycardia, tachypnea, increased diuresis, hypokalemia, hyponatremia, hyperglycemia, metabolic acidosis, convulsions, myoclonia and rhabdomyolysis, supraventricular and ventricular arrhythmias. Symptoms of chronic caffeine intoxication “caffeinism”: irritability, insomnia, anxiety, emotional lability, chronic abdominal pain.

• Chlorphenamine

Symptoms: central nervous system depression, hyperthermia, anticholinergic syndrome (mydriasis, flushing of blood to the face, fever, dry mouth, urinary retention, intestinal paresis), tachycardia, hypotension, hypertension, nausea, vomiting, agitation, disorientation, hallucinations, psychosis, convulsions, arrhythmias. Rarely, patients with agitation, seizures, or coma develop rhabdomyolysis and renal failure.

• Phenylephrine

Symptoms: nausea, vomiting, irritability, agitation, insomnia, psychosis, convulsions, palpitations, tachycardia, high blood pressure, reflex bradycardia.

• Paracetamol

Symptoms that occur after taking more than 7.5-10 g: during the first 24 hours after taking – pallor of the skin, nausea, vomiting; anorexia, abdominal pain; increased prothrombin time, impaired glucose metabolism, metabolic acidosis (including lactic acidosis). Symptoms of liver dysfunction may appear 12 to 48 hours after an overdose: increased activity of “liver” transaminases, hepatonecrosis. In severe cases – liver failure with progressive encephalopathy, coma. Rarely, liver failure develops rapidly and can be complicated by renal failure (tubular necrosis). The overdose threshold can be lowered in elderly patients and children, in patients taking certain medications (for example, inducers of microsomal liver enzymes), alcohol, or suffering from exhaustion. Treatment: gastric lavage, use of activated charcoal in the first 6 hours after overdose, use of SH-group donors and glutathione – methionine synthesis precursors in 8-9 hours after overdose and acetylcysteine in 12 hours. The need for additional therapeutic measures (further use of methionine and acetylcysteine) is determined by the concentration of paracetamol in the blood, as well as the time elapsed after taking it. Symptomatic therapy.

Description

Round flat tablets are pink in color with dark pink and white flecks, with beveled edges and a dividing risk on one side.

Special instructions

During the treatment period, you should refrain from taking alcohol, sleeping pills and anxiolytic (tranquilizers) medications. Do not take together with other medicines containing paracetamol. If the symptoms of the disease worsen or persist after 5 days of using the drug, you should stop taking it and consult your doctor. The drug may cause drowsiness. If the medicine has fallen into disrepair or the expiration date has expired, do not throw it into the sewer or on the street! Place the medicine in a plastic bag and put it in the trash can. These measures will help protect the environment!

Form of production

Tablets

Storage conditions

Store in a dry place, protected from light, at a temperature not exceeding 25 °C

Shelf life

3 years

Active ingredient

Caffeine, Paracetamol, Chlorphenamine, Phenylephrine

Dosage form

Tablets

Purpose

Children over 15 years old, For adults

Indications

Swelling of the nasal mucosa, Flu, Acute rhinitis, Fever, Headache, Runny nose, ARVI, Cold