Seknidox pills 1g, 2pcs

Composition

Active ingredient: secnidazole.

Pharmacological action

Pharmacodynamics . Secnidox is an antiprotozoal drug of the nitroimidazole group with an antibacterial effect. Secnidox is characterized by bactericidal (against gram – positive and gram-negative anaerobic bacteria) and amoebicidal (intra-and extra-intestinal) effects. Secnidox is particularly active against Trichomonas vaginalis, Entamoeba histolytica, Giardia lamblia. Penetrating deep into the cell of the microorganism, secnidazole is activated as a result of the reduction of the 5-nitro group, due to which it interacts with cellular DNA. There is a violation of its spiral-like structure and destruction of filaments, inhibition of nucleotide synthesis and cell death. Pharmacokinetics. After oral use, Secnidox is rapidly and completely absorbed in the gastrointestinal tract. Bioavailability is about 80%. Secnidazole penetrates the blood-brain barrier and is excreted in breast milk. The half-life of secnidazole is about 25 hours, which makes it possible to simplify the regimen of taking the drug, making it more convenient for patients.

Indications

Urethritis and vaginitis caused by Trichomonas vaginalis; intestinal amoebiasis caused by Entamoeba histolytica, liver amoebiasis caused by Entamoeba histolytica; giardiasis caused by Giardia lamblia.

Contraindications

Hypersensitivity to secnidazole, other imidazole derivatives or any other component of the drug; pregnancy and lactation; children under 3 years of age, or body weight less than 16 kg (for this dosage form)organic diseases of the central nervous system (CNS); blood diseases (including in the anamnesis).

Side effects

Allergic reactions: urticaria, rash, angioedema, very rarely-anaphylactic reaction. From the blood and lymphatic system: moderate reversible leukopenia. From the nervous system: dizziness, impaired coordination of movements (ataxia), decreased skin sensitivity (paresthesia), peripheral neuropathy. From the digestive system: nausea, vomiting, pain in the stomach, “metallic” taste in the mouth, glossitis, stomatitis. Other: fever.

How to take, course of use and dosage

The drug is taken orally, immediately before meals, with a small amount of water. Urethritis and vaginitis: Adults: A single dose of 2 g secnidazole (2 tablets), the course of treatment is 1 day. Both sexual partners should be treated simultaneously. Intestinal amoebiasis: Acute amoebiasis with severe symptoms (form histolytica): Adults: A single dose of 2 g secnidazole (2 tablets), the course of treatment is 1 day. Children: A single dose of 30 mg / kg, the course of treatment is 1 day. Amoebiasis without clinical symptoms, including focal and cystic forms (mi nut a and cystic): Adults: 2 g secnidazole (2 tablets) in one or more doses for 3 days. Children: 30 mg / kg / day in one or more doses for 3 days. Liver amoebiasis: Adults: 1.5 g secnidazole (1.5 tablets) in one or more doses for 5 days. Children: 30 mg / kg / day in one or more doses for 5 days. Giardiasis: Children: A single dose of 30 mg / kg, the course of treatment is 1 day.

Storage conditions

Store in a dark place, at a temperature not exceeding 25 °C. Keep out of reach of children.

Active ingredient

Secnidazole

Conditions of release from pharmacies

By prescription

Dosage form

Tablets