9 Months Folic pills 0.4g, 90pcs

Composition

1 tablet contains: Active ingredient: folic acid – 0.0004 g. Auxiliary substances: lactose monohydrate – 0.0936 g, colloidal silicon dioxide-0.0005 g, copovidone-0.0050 g, magnesium stearate-0.0005 g. Shell:  Opadrai II 85F22233-0.0030 g: polyvinyl alcohol, partially hydrolyzed-40.00%, macrogol-20.20%, talc-14.80%, titanium dioxide E 171-19.50%, iron oxide yellow dye E 172-0.10%, aluminum varnish based on quinoline yellow dye E 104-5.40%.

Pharmacological action

Vitamin B (vitamin B9, vitamin Bc), can be synthesized by the intestinal microflora. In the body, it is restored to tetrahydrofolic acid, which is a coenzyme involved in various metabolic processes. It is necessary for the normal maturation of megaloblasts and the formation of normoblasts. It stimulates erythropoiesis, participates in the synthesis of amino acids (including glycine, methionine), nucleic acids, pyrimidines, purines, and in the exchange of histidine and choline. Pharmacokinetics Folic acid is well and completely absorbed in the gastrointestinal tract, mainly in the upper duodenum. It binds almost completely to plasma proteins. It is activated in the liver under the influence of the enzyme dihydrofolate reductase, turning into tetrahydrofolic acid. The maximum concentration in blood plasma (Cmax) is reached after 30-60 minutes. Penetrates through the blood-brain and placental barriers into breast milk. It is excreted by the kidneys mainly in the form of metabolites; if the dose taken significantly exceeds the daily requirement for folic acid, it is excreted unchanged. It is removed by hemodialysis.

Indications

Folic acid deficiency. Prevention of neural tube defects in the fetus in the first trimester of pregnancy.

Use during pregnancy and lactation

Folic acid is necessary in the period of preparation for pregnancy (1-3 months before the planned pregnancy) and in the first few weeks after conception (I trimester).

Contraindications

Hypersensitivity to the components that make up the drug; pernicious anemia, malignant neoplasms, cobalamin deficiency, childhood.

Side effects

Allergic reactions (skin rash, pruritus, bronchospasm, erythema, hyperthermia); from the gastrointestinal tract: nausea, bloating, bitterness in the mouth, anorexia. With prolonged use, hypovitaminosis may develop in 12.

Interaction

Reduces the effectiveness of phenytoin (requires an increase in its dose). Analgesics (long-term therapy), anticonvulsants (including Phenytoin and carbamazepine). Estrogens, oral contraceptives increase the need for folic acid. Antacids, colestyramine, and sulfonamines (including sulfasalazine) reduce the absorption of folic acid. Methotrexate, pyrimethamine, triamterene, trimethoprim inhibit dihydrofolate reductase and reduce the effect of folic acid (instead, patients using these drugs should be prescribed calcium folinate). When used concomitantly with chloramphenicol, neomycin, polymyxins, tetracyclines, folic acid absorption decreases.

How to take, course of use and dosage

Apply inside after a meal. For folic acid deficiency – 400 mcg (1 tablet) per day. To prevent the development of neural tube defects in the fetus in the first trimester of pregnancy-400 mcg-800 mcg (1-2 tablets).

Overdose

It can occur with prolonged use (more than 1-2 months) of folic acid in doses of more than 1000 mcg per day and as a result of combined use with vitamin and mineral complexes.

Description

Round biconvex tablets covered with a yellow film coating. On a cross-section, the core is light yellow with flecks.

Special instructions

For the prevention of hypovitaminosis, a balanced diet is most preferable. Foods rich in folic acid include green vegetables (lettuce, spinach, tomatoes, carrots), fresh liver, legumes, beets, eggs, cheese, nuts, and cereals. Folic acid is not used for the treatment of B12-deficient (pernicious), normocytic and aplastic anemia, as well as anemia that is refractory to therapy. In pernicious (B12-deficient) anemia, folic acid, improving hematological parameters, masks neurological complications. Until pernicious anemia is ruled out, the use of folic acid in doses exceeding 100 mcg/day is not recommended (with the exception of pregnancy and lactation). It should be borne in mind that patients on hemodialysis need increased amounts of folic acid. During treatment, antacids should be used 2 hours after taking folic acid, colestyramine-4-6 hours before or 1 hour after taking folic acid. It should be borne in mind that antibiotics can distort (give deliberately underestimated indicators) the results of microbiological assessment of the concentration of folic acid in plasma and red blood cells. When using large doses of folic acid, as well as therapy for a long period, it is possible to reduce the concentration of vitamin B12.

Form of production

Film-coated tablets.

Storage conditions

The drug should be stored in a dry place, protected from light, inaccessible to children at a temperature not exceeding 25°C.

Shelf

life is 3 years.

Active ingredient

Folic acid

Dosage form

Tablets