Acathinol Memantine, pills 10mg, 90pcs

Composition

Coated tablets

1 table. :

memantine hydrochloride 10 mg

excipients:

lactose;

MCC;

colloidal silicon dioxide;

talc;

magnesium stearate shell:

methacrylic acid copolymer;

sodium lauryl sulfate;

polysorbate 80;

triacetin;

simethicone emulsion;

talc

Pharmacological action

Acatinol Memantine is a central-acting muscle relaxant.

Being a non-competitive antagonist of N-methyl-D-aspartate (NMDA) receptors, it has a modulating effect on the glutamatergic system.

Regulates ion transport, blocks calcium channels, normalizes membrane potential, improves the process of nerve impulse transmission, improves cognitive processes, memory and learning ability, and increases daily activity.

Indications

• Alzheimer’s type dementia, vascular dementia, mixed dementia of all degrees of severity.
• Reduced memory, concentration, and learning abilities.
• Cerebral and spinal spastic syndrome, including due to traumatic brain injury, multiple sclerosis, stroke.

Use during pregnancy and lactation

Contraindicated in pregnancy.

Breast-feeding should be discontinued for the duration of treatment.

Contraindications

• individual hypersensitivity to the drug;
• severe renal dysfunction;
• pregnancy;
• breastfeeding;
• children under 18 years of age (due to insufficient data).

With caution:

• thyrotoxicosis;
• epilepsy;
• convulsions (including in the anamnesis);
• myocardial infarction;
• heart failure.

Side effects

Adverse reactions are classified according to clinical manifestations (according to specific organ systems) and frequency of occurrence: very common – ≥1/10; often – ≥1/100–

On the part of the body as a whole — common adverse reactions

Often

Headache

Rarely

Fatigue

Infections

Rarely

Fungal infections

Mental disorders

Are Common

Drowsiness

Rarely

Confusion of consciousness

Rarely

Hallucinations

Frequency not established

Psychotic reactions

Disorders of the cardiovascular system

Rarely Hypertension

Rarely Venous thrombosis / thromboembolism

Gastrointestinal disorders

Often Constipation

Rare nausea, vomiting

Frequency not established

Pancreatitis

Central and peripheral nervous system disorders

Often Dizziness

Rarely Gait disorder

Very rarely, Seizures

and Hallucinations were observed, mainly in patients with Alzheimer’s disease at the stage of severe dementia.

2 There are isolated reports of these adverse reactions occurring with the use of the drug in clinical practice (data obtained after the drug became commercially available).

Interaction

When used concomitantly with L-dopa preparations, dopamine agonists, and anticholinergic agents, the effect of the latter may be enhanced.

When used concomitantly with barbiturates, neuroleptics, the effect of the latter may decrease.

When used together, it can change (increase or decrease) the effect of dantrolene or baclofen, so the dosage of drugs should be selected individually.

Concomitant use with amantadine, ketamine, and dexamethorphan should be avoided.

It is possible to increase plasma levels of cimetidine, procainamide, kinidine, kinine and nicotine when taken simultaneously with memantine.

It is possible to reduce the level of hydrochlorothiazide when taken simultaneously with memantine.

How to take, course of use and dosage

Acatinol Memantine is taken orally, with meals. The dosage regimen is set individually. It is recommended to start treatment with the minimum effective dose.

Adults with dementia during the 1st week of therapy — at a dose of 5 mg / day, the 2nd week-at a dose of 10 mg/day, the 3rd week-at a dose of 15-20 mg/day. If necessary, a further weekly dose increase of 10 mg is possible until the daily dose of 30 mg is reached.

The optimal dose is achieved gradually, with an increase in the dose every week.

Overdose

Symptoms:  increased severity of side effects.

Treatment:  gastric lavage, taking activated charcoal, symptomatic therapy.

Special instructions

Patients with moderate to severe Alzheimer’s disease usually have impaired ability to drive vehicles and manage complex mechanisms.

In addition, memantine can cause changes in the reaction rate, so patients receiving outpatient treatment should take special care when driving vehicles or operating mechanisms.

Form of production

Coated tablets.

Storage conditions

At a temperature not exceeding 25 °C

Shelf life

4 years

Active ingredient

Memantine

Conditions of release from pharmacies

By prescription

Dosage form

Tablets

Description

For adults as directed by your doctor

Indications

Acquired dementia, Alcoholism, Alzheimer’s disease, Concussion and other traumatic brain injuries, Stroke consequences