Adepress, pills 20mg, 30pcs

Composition

1 tab. contains paroxetine (in the form of hemihydrate hydrochloride) 20 mg;

excipients:

calcium hydrophosphate (double-substituted calcium phosphate),

corn starch,

sodium carboxymethyl starch (primogel),

magnesium stearate

Pharmacological action

Adepress is an antidepressant. It is a selective inhibitor of serotonin (5-hydroxytryptamine,5-HT) reuptake by brain neurons, which determines its antidepressant effect and effectiveness in the treatment of obsessive-compulsive (OCD) and panic disorder.

Paroxetine has a low affinity for m-cholinergic receptors (it has a weak anticholinergic effect), α1 -, α2-and β-adrenergic receptors, as well as for dopamine (D2),5HT1-like,5HT2-like and histamine H1-receptors.

Paroxetine does not interfere with psychomotor functions and does not potentiate the depressing effect of ethanol on them.

According to a behavioral and EEG study, paroxetine has weak activating properties when given at doses higher than those required to inhibit serotonin uptake. In healthy volunteers, it does not cause significant changes in blood pressure, heart rate, and EEG.

Indications

• All types of depression, including reactive depression, severe endogenous depression, and anxiety-related depression.
• Obsessive-compulsive disorder (OCD)
• Panic disorder, including fear of being in a crowd (agoraphobia);
• Social anxiety disorder/social phobia;
• Generalized anxiety disorder.
• Post-traumatic stress disorder.

Use during pregnancy and lactation

Adepress is not recommended for pregnant women and nursing mothers.

Contraindications

• Simultaneous use of MAO inhibitors and a period of 14 days after their withdrawal;
• Unstable epilepsy;
• Pregnancy and lactation (breastfeeding);
• Children’s age;
• Hypersensitivity to the components of the drug.

With caution: in case of hepatic insufficiency, renal insufficiency, angle-closure glaucoma, prostatic hyperplasia, mania, cardiac pathology, epilepsy, convulsive states, simultaneous use of electro-pulse therapy, simultaneous use of drugs that increase the risk of bleeding, the presence of risk factors for increased bleeding and diseases that increase the risk of bleeding, as well as in elderly patients.

Side effects

From the central nervous system and peripheral nervous system:  often-drowsiness or insomnia, tremor, asthenia, dizziness, anxiety; sometimes-confusion, hallucinations, extrapyramidal disorders, paresthesia, decreased ability to concentrate; rarely – convulsions, mania; very rarely – serotonin syndrome (agitation, hyperreflexia, diarrhea), panic disorders.

From the side of the senses:  in some cases – visual impairment, mydriasis.

Musculoskeletal disorders:  rarely — myasthenia gravis, myoclonia, arthralgia, myalgia.

From the urinary system:  frequent urination; rarely-urinary retention.

From the side of the reproductive system:  ejaculatory disorders, libido disorders; rarely-hyperprolactinemia/galactorrhea, anorgasmia.

From the digestive system:  decreased appetite, nausea, vomiting, dry mouth; sometimes-constipation or diarrhea; in some cases-hepatitis.

From the cardiovascular system:  orthostatic hypotension.

Allergic reactions:  rarely-rash, urticaria, ecchymatosis, pruritus, angioedema.

Other services:  increased sweating; in some cases – hyponatremia, impaired secretion of antidiuretic hormone.

How to take, course of use and dosage

Take Adepress tablets 1 time / day, in the morning, with meals, without chewing, with water.

The dose is selected individually during the first 2-3 weeks after the start of therapy and subsequently adjusted if necessary. The effect in most cases develops gradually. The dose should be increased by 10 mg every week until the therapeutic effect is achieved. The maximum daily dose should not exceed 60 mg / day.

In patients with renal and/or hepatic insufficiency, the recommended dose is 20 mg / day.

For elderly patients, the daily dose should not exceed 40 mg.

Maintenance therapy is necessary to prevent relapses. After the symptoms of depression disappear, this course can be 4-6 months, and for obsessive and panic disorders-more than 4-6 months.

Abrupt discontinuation of the drug should be avoided. In order to prevent the development of withdrawal syndrome, discontinuation of Adepress should be carried out gradually.

Special instructions

In order to avoid the development of neuroleptic malignant syndrome, Adepress should be prescribed with caution to patients taking neuroleptics.

In elderly patients, hyponatremia is possible while taking Adepress.

In some cases, it is necessary to adjust the dose of concomitantly administered insulin and / or oral hypoglycemic drugs.

If seizures develop, treatment with Adepress is discontinued.

At the first sign of mania, the drug should be discontinued.

During the first few weeks of Adepress therapy, the patient’s condition should be carefully monitored for possible suicide attempts.

During therapy with Adepress, you should refrain from taking alcohol due to the increase in its toxic effect.

Influence on the ability to drive motor vehicles and manage mechanisms

Despite the fact that paroxetine does not impair cognitive and psychomotor functions, patients should refrain or exercise extreme caution when driving a car and when engaging in other potentially dangerous activities that require increased concentration and speed of psychomotor reactions.

Form of production

Film-coated tablets

Storage conditions

Store in a dry place, protected from light, at a temperature not exceeding 25 °C

Shelf life

2 years

Active ingredient

Paroxetine

Conditions of release from pharmacies

By prescription

Dosage form

Tablets

Description

Adults as prescribed by a doctor

Indications

Phobias and panic attacks, Stress