Antigrippin, effervescent pills for children, 10pcs

Composition

1 effervescent tablet contains:

Active ingredients:

paracetamol-250 mg,

ascorbic acid-50 mg,

chlorphenamine maleate-3 mg.

Auxiliary substances:

sodium bicarbonate;

citric acid;

sorbitol;

povidone;

sodium saccharinate;

sodium carbonate;

macrogol;

silicon dioxide;

fruit flavor (aromatic fruit additive “Red fruits”)

Pharmacological action

Combined drug.

Paracetamol-has analgesic and antipyretic effects, eliminates headaches and other types of pain, reduces fever.

Ascorbic acid (vitamin C) — participates in the regulation of redox processes, carbohydrate metabolism, increases the body’s resistance.

Chlorphenamine-a blocker of H1-histamine receptors-has an anti-allergic effect, facilitates breathing through the nose, reduces the feeling of nasal congestion, sneezing, lacrimation, itching and redness of the eyes.

Indications

Infectious and inflammatory diseases (ARVI, flu), accompanied by:

• fever,
• joint and muscle pain,
• chills,
• headache,
• nasal congestion,
• sore throat and sinuses.

Use during pregnancy and lactation

Contraindicated in pregnancy.

Breast-feeding should be discontinued for the duration of treatment.

Contraindications

• Hypersensitivity to paracetamol, ascorbic acid, chlorphenamine or any other component of the drug.
• Erosive and ulcerative lesions of the gastrointestinal tract (in the acute phase).
• Severe renal and / or hepatic insufficiency.
• Angle-closure glaucoma.
• For powder for the preparation of a solution for oral use of honey-lemon or chamomile, effervescent tablets with raspberry or grapefruit flavor, effervescent tablets (optional): alcoholism; phenylketonuria; prostatic hyperplasia; children under 15 years of age; pregnancy; lactation.
• For effervescent tablets for children (optional) — children under 3 years of age.

With caution:

renal and / or hepatic insufficiency; glucose-6-phosphate dehydrogenase deficiency; congenital hyperbilirubinemia (Gilbert, Dubin-Johnson and Rotor syndromes); viral hepatitis. For powder for preparing a solution for oral use of honey-lemon or chamomile, effervescent tablets with raspberry or grapefruit flavor, effervescent tablets (optional): alcoholic hepatitis; elderly age; hyperoxalaturia (effervescent tablets with raspberry or grapefruit flavor); progressive malignant diseases (effervescent tablets with raspberry or grapefruit flavor).

Side effects

The drug is well tolerated in the recommended doses. In isolated cases, there are:

From the central nervous system:  headache, feeling tired.

From the gastrointestinal tract:  nausea, epigastric pain.

From the endocrine system:  hypoglycemia (up to the development of coma).

From the side of hematopoietic organs:  anemia, hemolytic anemia (especially for patients with glucose-6-phosphate dehydrogenase deficiency); extremely rare — thrombocytopenia.

Allergic reactions:  skin rash, pruritus, urticaria, angioedema.

Other services:  hypervitaminosis, metabolic disorders, heat sensation, dry mouth, accommodation paresis, urinary retention, drowsiness.

For powder for preparation of a solution for oral use of honey-lemon, effervescent tablets with raspberry or grapefruit flavor (optional):  anaphylactoid reactions (including anaphylactic shock), erythema multiforme (including Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell’s syndrome).

All side effects of the drug should be reported to the doctor.

Interaction

Ethanol enhances the sedative effect of antihistamines.

Antidepressants, antiparkinsonian agents, antipsychotic agents (phenothiazine derivatives): increase the risk of side effects (urinary retention, dry mouth, constipation).

CORTICOSTEROIDS: increase the risk of glaucoma.

When used concomitantly, the positive chronotropic effect of isoprenaline decreases.

Reduces the therapeutic effect of antipsychotic drugs (neuroleptics) – phenothiazine derivatives, tubular reabsorption of amphetamine and tricyclic antidepressants.

Inducers of microsomal oxidation in the liver (phenytoin, ethanol, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants): increase the production of hydroxylated active metabolites, which causes the possibility of severe intoxication with small overdoses. Ethanol contributes to the development of acute pancreatitis.

Inhibitors of microsomal oxidation (including cimetidine): reduce the risk of hepatotoxic effects.

Simultaneous use of the drug Antigrippin and diflunizal: the concentration in the blood plasma of paracetamol increases by 50%, resulting in increased hepatotoxicity.

Simultaneous use of barbiturates reduces the effectiveness of paracetamol, increases the excretion of ascorbic acid in the urine.

Paracetamol: reduces the effectiveness of uricosuric drugs.

How to take, course of use and dosage

Inside.

Effervescent tablets for children: from 3 to 5 years-1/2 table. 2 times a day, from 5 to 10 years-1 table. 2 times a day, from 10 to 15 years — 1 tablet 2-3 times a day.

The contents of the sachet or tablet should be completely dissolved in a glass (200 ml) of warm water (50-60 °C) and the resulting solution should be drunk immediately. It is better to take the drug between meals. The interval between doses of the drug should be at least 4 hours.

In patients with impaired liver or kidney function and in elderly patients, the interval between doses of the drug should be at least 8 hours.

The duration of admission without consulting a doctor is not more than 5 days when prescribed as an analgesic and 3 days – as an antipyretic.

Overdose

Symptoms: due to the substances included in the composition. The clinical picture of acute paracetamol overdose develops within 6-14 hours after taking it.

Symptoms of chronic overdose: occur 2-4 days after increasing the dose of the drug.

Symptoms of acute paracetamol overdose: diarrhea, decreased appetite, nausea and vomiting, abdominal discomfort and / or abdominal pain, increased sweating.

Symptoms of chlorphenamine overdose: dizziness, agitation, sleep disturbance, depression, seizures.

Treatment: symptomatic.

Special instructions

If you are taking metoclopramide, domperidone, or colestyramine, you should consult your doctor.

With prolonged use in doses significantly higher than recommended, the likelihood of impaired liver and kidney function increases, and monitoring of the peripheral blood picture is necessary.

Paracetamol and ascorbic acid can distort laboratory tests (quantitative determination of glucose and uric acid in blood plasma, bilirubin, hepatic transaminase activity, LDH).

Prescribing ascorbic acid to patients with rapidly proliferating and intensely metastatic tumors may worsen the course of the process. In patients with high iron content in the body, ascorbic acid should be used in minimal doses.

Form of production

Effervescent tablets for children.

Storage conditions

At a temperature of 10-30 °C

Shelf life

3 years

Active ingredient

Paracetamol, Chlorphenamine, [Ascorbic Acid]

Dosage form

soluble tablets

Description

Children over 3 years old

Indications

ARVI, Cold, Fever, Sore throat, Headache, Runny nose, Flu, Myalgia, Otitis media, Joint pain