Atorvastatin-Teva, pills 10mg 30pcs

Composition

1 tablet contains atorvastatin (in the form of calcium salt) 10 mg

Pharmacological action

Atorvastatin is a hypolipidemic agent from the statin group. According to the principle of competitive antagonism, the statin molecule binds to the part of the coenzyme A receptor where HMG-CoA reductase is attached.

Another part of the statin molecule inhibits the conversion of hydroxymethylglutarate to mevalonate, an intermediate in the synthesis of the cholesterol molecule.

Inhibition of HMG-CoA reductase activity leads to a series of sequential reactions, which result in a decrease in the intracellular cholesterol content and a compensatory increase in the activity of LDL receptors and, accordingly, an acceleration of LDL cholesterol (Xc) catabolism.

Indications

Primary hypercholesterolemia when diet therapy is ineffective, combined hypercholesterolemia and hypertriglyceridemia, heterozygous and homozygous familial hypercholesterolemia when diet therapy is ineffective.

Use during pregnancy and lactation

It is not known whether atorvastatin is excreted in breast milk. Taking into account the possibility of adverse events in infants, if it is necessary to use the drug during lactation, the question of stopping breastfeeding should be decided.

Women of reproductive age should use adequate methods of contraception during treatment.

Atorvastatin can be prescribed to women of reproductive age only if the probability of pregnancy is very low, and the patient is informed about the possible risk of treatment for the fetus.

Contraindications

Liver diseases in the active stage, increased activity of serum transaminases more than 3 times of unknown origin, pregnancy, lactation (breastfeeding), hypersensitivity to atorvastatin.

Women of reproductive age who do not use reliable contraceptives.

Atorvastatin is contraindicated for use during pregnancy and lactation (breastfeeding).

Interaction

The risk of myopathy during treatment with other drugs derived from statins increases with the simultaneous use of cyclosporine, fibrates, erythromycin, antifungal agents related to azoles, and nicotinic acid.

 With simultaneous ingestion Atorvastatin and a suspension containing magnesium hydroxide and aluminum hydroxide, the concentration of atorvastatin in blood plasma decreased by about 35%, but the degree of reduction in LDL-C levels did not change.

 When used simultaneously Atorvastatin does not affect the pharmacokinetics of antipyrine (phenazone), so interaction with other drugs metabolized by the same cytochrome P450 isoenzymes is not expected.

How to take, course of use and dosage

Treatment is carried out against the background of a standard diet for patients with hypercholesterolemia. The dose Atorvastatin is set individually, depending on the initial cholesterol level. They are taken orally.

The initial dose is usually 10 mg once a day. The effect manifests itself within 2 weeks, and the maximum effect-within 4 weeks. If necessary, the dose can be gradually increased at intervals of 4 weeks or more. The maximum daily dose of Atorvastatin is 80 mg.

Overdose

Treatment:  there is no specific antidote, and symptomatic therapy is performed.

Hemodialysis is ineffective.

Special instructions

Before and during treatment with Atorvastatin, especially if symptoms of liver damage appear, it is necessary to monitor liver function indicators.

If the level of transaminases increases, their activity should be monitored until normalization. If the activity of AST or ALT, more than 3 times higher than normal, persists, it is recommended to reduce the dose or cancel Atorvastatin.

Form of production

Film-coated tablets

Storage conditions

At a temperature not exceeding 30 °C

Shelf life

2 years

Active ingredient

Atorvastatin

Conditions of release from pharmacies

By prescription

Dosage form

Tablets

Description

For adults as directed by your doctor

Indications

Prevention of heart attacks and strokes, Atherosclerosis