Baclosan, pills 25mg, 50pcs

Composition

Active ingredient-baclofen 25 mg;

Excipients-lactose,

potato starch,

gelatin,

talc,

magnesium stearate,

ethylcellulose.

Pharmacological action

Baclosan – antispasmodic, muscle relaxant.

Pharmacodynamics

Reducing the excitability of the end sections of afferent sensory fibers and suppressing intermediate neurons, it inhibits mono – and polysynaptic transmission of nerve impulses; reduces the preliminary tension of muscle spindles. It has no effect on neuromuscular transmission.

In neurological diseases accompanied by skeletal muscle spasticity, it reduces painful spasms and clonic seizures; increases the amount of movement in the joints, facilitates passive and active kinesotherapy (physical exercises, massage, manual therapy).

Pharmacokinetics

After oral use, Cmax in blood plasma is reached in 2-3 hours. Absorption is high. Protein binding — 30%. Penetrates the placental barrier, is excreted in breast milk. It is metabolized in the liver. It is excreted by the kidneys (mainly in unchanged form).

Indications

• Increased muscle tone in multiple sclerosis; 
• diseases of the spinal cord of infectious, degenerative and traumatic origin (for example, syringomyelia tumors, motor neuron diseases, injuries);
• stroke;
• cerebral palsy; 
• meningitis; 
• traumatic brain injuries;
• alcoholism (affective disorders).

Contraindications

• psychosis
• epilepsy
• Parkinson
• ‘s disease hypersensitivity to Baclosan.

Side effects

Nausea, vomiting, drowsiness, dizziness, increased fatigue, dry mouth, confusion, gait disorders, urinary retention, constipation or diarrhea, decreased blood pressure, apathy; euphoria, depression, paresthesia, myalgia, muscle weakness, ataxia, tremor, nystagmus, accommodation paresis, hallucinations, dysuria, enuresis, convulsions, decreased seizure threshold.

With prolonged use – impaired renal function.

Interaction

Increases the effect of drugs that affect the central nervous system, antihypertensive drugs, ethanol.

Tricyclic antidepressants increase the decrease in muscle tone; levodopa and cardidopa increase the risk of hallucinations, confusion, and agitation.

Patients should inform their doctor about all medications they are taking.

How to take, course of use and dosage

Inside, while eating. If you miss the next appointment, you should not take a double dose of the drug.

Adults: an initial dose of 5 mg (1/2 tablet of 10 mg) 3 times a day. Gradually increase the dose of the drug every 3 days until the therapeutic effect occurs (usually up to 30-75 mg per day).

In patients requiring higher doses of Baclofen (from 75 mg to 100 mg per day), the drug should be used in tablets of 25 mg. In patients over 65 years of age, the dose of the drug should be increased with caution due to the increased risk of side effects. The maximum daily dose is 100 mg

. Children: the initial dose is 5 mg (1/2 tablet of 10 mg) 3 times a day. If necessary, the dose can be increased with caution every 3 days. The following doses are usually recommended: from 1 to 2 years-10-20 mg per day, from 2 years to 6 years-20-30 mg per day, from 6 to 10 years-30-60 mg per day. In children over 10 years of age, the maximum dose is 1.5-2.0 mg / kg of body weight.

Overdose

Symptoms: muscle hypotension, respiratory depression, confusion, coma (after returning to consciousness, muscle hypotension may persist for 72 hours).

Treatment: heavy drinking, taking diuretics, with respiratory depression – mechanical ventilation. There is no specific antidote.

Special instructions

In patients with liver diseases and diabetes mellitus, it is necessary to periodically monitor the activity of” liver ” transaminases, alkaline phosphotase, and blood glucose.

During treatment, you should refrain from potentially dangerous activities associated with the need for increased attention and rapid mental and motor reactions.

Form of production

Tablets

Storage conditions

Store in a dry place, protected from light, at a temperature not exceeding 25 °C

Shelf life

3 years

Active ingredient

Baclofen

Conditions of release from pharmacies

By prescription

Dosage form

Tablets

Description

For adults as prescribed by a doctor, Children over 12 years of age, Children as prescribed by a doctor

Indications

Muscle spasm, Concussion and other traumatic brain injuries, Alcoholism, Stroke consequences