Basiron AC, gel 2.5%, 40g

Composition

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of 1 g of gel for external use contains:

Active ingredient:

benzoyl peroxide 25 mg;

excipients:

amethacrylic acid copolymer;

poloxamer 182;

carbomer 940;

glycerol;

disodium edetate;

sodium docusate;

propylene glycol;

colloidal silicon dioxide;

sodium hydroxide;

purified water.

Pharmacological action

Baziron AC has a high antimicrobial activity against Propionibacterium acnes and Staphylococcus epidermidis, has a comedonolytic and anti-inflammatory effect, improves tissue oxygenation, suppresses sebum production in the sebaceous glands, absorbs excess sebaceous secretions and moisturizes the skin.

In vivo studies based on the results of inoculation showed that 94% inhibition of the growth of Propionibacterium acnes culture was observed on day 7, and 97-99% on day 15.

The anti-inflammatory effect of benzoyl peroxide is based on the inactivation of free radicals in the focus of inflammation and the inhibition of free fatty acids.

The base of the preparation is represented by the acrylate copolymer/glycerin complex; this ensures controlled adsorption of excess sebum and gradual release of glycerol to soften and moisturize the skin.

Pharmacokinetics

Penetration of benzoyl peroxide through the skin is low. The main part of benzoyl peroxide is converted to benzoic acid, which, after absorption, enters the systemic bloodstream and is quickly excreted by the kidneys.

There is no accumulation in the tissues. The cutaneous use of Basiron AC in therapeutic doses does not lead to systemic side effects.

Indications

Acne.

Use during pregnancy and lactation

Controlled clinical trials of the drug during pregnancy and lactation have not been conducted.

During the long-term clinical use of Baziron AS, there were no cases of toxic effects on the fetus or malformations.

The use of Baziron AC gel during pregnancy and breast-feeding is possible in cases where the intended benefit to the mother exceeds the potential risk to the fetus.

Contraindications

Hypersensitivity to one of the ingredients of the drug; children under 12 years of age.

Side effects

In rare cases: local irritation — redness, flaking, dry skin, burning sensation (it is recommended to reduce the frequency of use); allergic contact dermatitis.

How to take, course of use and dosage

The gel should be applied to a clean and dry surface of the affected skin 1 or 2 times a day (morning or evening).

The course of treatment is 3 months. The therapeutic effect develops 4 weeks after the start of the drug. Persistent improvement occurs after 3 months of therapy.

Baziron AC is indicated for the treatment of mild to moderate acne with a predominance of pustular elements as monotherapy, and for moderate acne also in combination with other local (retinoids) and systemic (antibiotics, oral antiandrogens).

If necessary, it is possible to conduct a second course of treatment.

Special instructions

Avoid contact with Baziron AC gel on the mucous membranes of the eyes, mouth and nose.

In case of accidental contact with the mucous membranes, rinse them thoroughly with warm water.

The simultaneous use of products with exfoliating, drying or irritating effects (for example, products containing alcohol) is not recommended.

We do not recommend sun and UV exposure, which are an additional cause of skin irritation.

Form of production

Gel for external use

Storage conditions

At a temperature not exceeding 25 °C

Shelf life

3 years

Active ingredient

Benzoyl Peroxide

Dosage form

gel for external use

Description

For adults, Children over 12 years of age

Indications

Acne