Benfogamma 150 pills, 30pcs

Composition

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of 1 tablet contains:  

Active ingredient:

benfotiamine 150 mg,

excipients:

microcrystalline cellulose 122.0 mg,

povidone K-30 8.0 mg,

fatty acid glycerides 5.0 mg,

colloidal silicon dioxide 7.0 mg,

sodium carmellose 3.0 mg,

talc 10.0 mg;

shell composition:

shellac 3.0 mg,

sucrose 70,875 mg,

calcium carbonate 66,479 mg,

talc 41,314 mg,

acacia gum 10,155 mg,

corn starch 7,340 mg,

titanium dioxide 10,932 mg,

silicon dioxide colloid 4,404 mg,

povidone K-30 6,210 mg,

macrogol-6000 1,597 mg

glycerol 85% 2,262 mg,

Polysorbate 80 of 0.133 mg,

wax mountain glycolic 0,300 mg

Pharmacological action

Benfotiamine is a fat-soluble derivative of thiamine. Thiamine is converted to active thiamine pyrophosphate and as a coenzyme, it is included in the pyruvate decarboxylase, alpha-ketoglutarate decarboxylase complexes, which are involved in the oxidative decarboxylation of pyruvic and alpha-ketoglutaric acids; transketolase is an enzyme of the pentose phosphate shunt.

Pharmacokinetics

Absorption is high, throughout the small intestine. Before absorption, it is released from its bound state by digestive enzymes. After 15 minutes, it is detected in the blood, after 30 minutes-in other tissues. The concentration in the blood is relatively low, while free thiamine circulates mainly in the plasma, and its phosphorous esters in red blood cells and white blood cells. Phosphorylation occurs in the liver.

The most active phosphoric ester is thiamine diphosphate, which has coenzyme activity. It accumulates mainly in the liver, heart, brain, kidneys, and spleen. 1/2 of the total amount is found in striated muscles and myocardium, and about 40% in internal organs. It is excreted through the intestines and kidneys.

Indications

B1 deficiency confirmed by clinical and biochemical studies, developing against the background of:

• poor nutrition (beriberi);
• parenteral nutrition for a long time, hemodialysis;
• chronic alcoholism (alcoholic cardiomyopathy, Wernicke’s encephalopathy, Korsakov’s syndrome);
• increased need for vitamin_b1.

Polyneuropathy caused by vitamin B_{-1 deficiency}. Typical signs of this deficiency are neurological disorders in the form of neuropathies with sensory disturbances (pain, tingling, loss of sensitivity in the upper and lower extremities).

Use during pregnancy and lactation

Pregnancy is a contraindication for the use of the drug.

Contraindications

• Increased individual sensitivity to the components of the drug,
• sucrose/isomaltose deficiency,
• fructose intolerance glucose-galactose malabsorption,
• 1 period of pregnancy,
• childhood.

Side effects

Allergic reactions: angioedema, urticaria, pruritus.

Interaction

Thiamine weakens the effect of depolarizing muscle relaxants (suxamethonium iodide, etc. ), and is inhibited by fluorouracil. Ethanol slows down the rate of absorption of thiamine after oral use.

How to take, course of use and dosage

For the treatment of vitamin B deficiency₁: 1 tablet once a day.

For the treatment of polyneuropathies caused by vitamin B_{1 deficiency}: an initial dose of 1 tablet 2 times a day for 3 weeks, then 1 tablet daily.

The duration of treatment depends on its effectiveness and is determined by the doctor.

The tablet is taken without chewing, washed down with a small amount of water.

Overdose

No overdose of Benfogamma 150 has been reported so far.

Special instructions

No adverse reactions other than those mentioned above were observed in the elderly. It is not recommended to take a double dose of the drug if the previous dose was missed. In Wernicke’s encephalopathy, the use of dextrose should be preceded by thiamine.

Effect on the ability to drive vehicles and mechanismminutes of data on the effect of the drug on the ability to drive vehicles and mechanisms used in therapeutic doses.

Form of production

Dragees

Storage conditions

At a temperature not exceeding 25 °C

Shelf life

5 years

Active ingredient

Benfotiamine

Conditions of release from pharmacies

By prescription

Dosage form

Tablets

Indications

Alcoholism, Polyneuropathy, Malnutrition