Betahistine Canon pills 16mg, 30pcs

Composition

1 tablet contains:

Active ingredient:

betahistine dihydrochloride 16 mg;

Auxiliary substances:

MCC;

lactose (milk sugar);

citric acid monohydrate;

colloidal silicon dioxide (aerosil);

crospovidone;

talc;

magnesium stearate.

Pharmacological action

Synthetic analog of histamine. It is a weak agonist of histamine_H1-receptors and a fairly powerful antagonist of histamine_H3-receptors. It has a histamine-like and vasodilating effect. It affects the cochlear blood flow and the central vestibular apparatus.

The effect of the drug includes vasodilation in the inner ear (mediated through histamine_{H3 and H1}receptors), an inhibitory effect on the vestibular nuclei (through histamine_H3receptors) and the pulse activity of ampullary receptors. By direct agonistic action on histamine_H1-receptors of the inner ear vessels and precapillary sphincters of the microcirculatory bed located in the vascular strip (stria vascularis), as well as indirectly through histamine_H3-receptors, it improves microcirculation and capillary permeability of the inner ear, normalizes endolymph pressure in the labyrinth and cochlea, increases blood flow in the basilar artery.

It has a pronounced central effect, being an antagonist of histamine_H3-receptors of the vestibular nerve nuclei. Normalizes the conduction in polysynaptic neurons of the vestibular nuclei at the level of the brain stem. Indirectly acting on histamine_H3receptors, it increases the content of serotonin in the brain stem, which reduces the activity of the vestibular nuclei.

Helps to eliminate disorders of both the vestibular and cochlear apparatus: reduces the frequency and intensity of dizziness, reduces tinnitus, improves hearing in cases of its decline.

Betahistine stimulates histamine_H1receptors, so it does not have a sedative effect and does not cause drowsiness.

Indications

• Dropsy of the inner ear labyrinth;
• Vestibular and labyrinth disorders, including dizziness, noise and pain in the ears, headache, nausea, vomiting, hearing loss;
• Vestibular neuritis;
• Labyrinthitis.
• Benign positional vertigo (including after neurosurgical operations);
• Meniere’s disease;
• Vertebrobasilar insufficiency, post-traumatic encephalopathy, cerebral vascular atherosclerosis (as part of complex therapy).

Use during pregnancy and lactation

There is insufficient data to assess the effects of the drug during pregnancy and lactation. In this regard, reception during pregnancy is contraindicated.

Breast-feeding should be discontinued for the duration of treatment.

Contraindications

• hypersensitivity to any of the components of the drug;
• lactose intolerance;
• lactase deficiency or glucose-galactose malabsorption;
• age under 18 years;
• pregnancy;
• lactation period.

With caution:

• peptic ulcer of the stomach and duodenum (in the anamnesis);
• pheochromocytoma;
• bronchial asthma.

Side effects

Gastrointestinal disorders, allergic reactions from the skin (skin rash, itching, urticaria), angioedema.

Interaction

Interactions or incompatibilities with other medicinal products are unknown.

How to take, course of use and dosage

Inside, while eating. 1/2-1 tablet 3 times a day.

Improvement is usually noted at the beginning of therapy.

A stable therapeutic effect occurs after two weeks of treatment and may increase over several months of treatment.

Long-term treatment. The duration of taking the drug is selected individually.

Overdose

Symptoms: nausea, vomiting, convulsions.

Treatment: gastric lavage, taking activated charcoal, symptomatic therapy.

Special instructions

The therapeutic effect of the drug in some cases appears only a few months after the start of treatment.

Form of production

Pills.

Storage conditions

Store in a dry place, protected from light, at a temperature not exceeding 25 °C

Shelf life

2 years

Active ingredient

Betahistine

Conditions of release from pharmacies

By prescription

Dosage form

Tablets

Description

For adults, For adults as prescribed by a doctor

Indications

Meniere’s disease, Cerebrovascular Accident