Betahistine Canon pills 24mg, 60pcs

Composition

1 tablet contains:

Active ingredient:

betahistine dihydrochloride 24 mg;

Auxiliary substances:

MCC;

lactose (milk sugar);

citric acid monohydrate;

colloidal silicon dioxide (aerosil);

crospovidone;

talc;

magnesium stearate.

Pharmacological action

Betahistine is a histaminergic substance that improves microcirculation.

Pharmacodynamics

Agonist of H1-receptors of the inner ear vessels and antagonist of H3-receptors of the vestibular central nervous system. By direct agonistic action on the H1 receptors of the inner ear vessels, as well as indirectly through exposure to H3 receptors, it improves microcirculation and capillary permeability, normalizes endolymph pressure in the labyrinth and cochlea, and increases blood flow in the basilar artery.

It has a pronounced central effect, being an inhibitor of H3 – receptors of the vestibular nerve nuclei. Improves conduction in neurons of the vestibular nuclei at the level of the brain stem.

The clinical manifestation of these properties is a decrease in the frequency and intensity of dizziness, a decrease in tinnitus, and an improvement in hearing in the case of its decrease.

Pharmacokinetics

Absorbed quickly, binding to plasma proteins is low. The time required to reach MAX is 3 hours —

It is almost completely excreted by the kidneys as a metabolite (2-pyridylacetic acid) within 24 hours. T1/2 — 3-4 hours.

Indications

• treatment and prevention of vestibular vertigo of various origins;
• syndromes including dizziness and headache, tinnitus, progressive hearing loss, nausea and vomiting;
• Meniere’s disease or syndrome.

Use during pregnancy and lactation

There are insufficient data to assess the effects of the drug during pregnancy and lactation.

In this regard, it is not recommended to take it during pregnancy. Breast-feeding should be discontinued for the duration of treatment.

Contraindications

• hypersensitivity to any of the components of the drug;
• lactose intolerance;
• lactase deficiency or glucose-galactose malabsorption;
• age under 18 years;
• pregnancy;
• lactation period.

With caution:

• peptic ulcer of the stomach and duodenum (in the anamnesis);
• pheochromocytoma;
• bronchial asthma.

Side effects

Gastrointestinal disorders, allergic reactions from the skin (skin rash, itching, urticaria), angioedema.

Interaction

Interactions or incompatibilities with other medicinal products are unknown.

How to take, course of use and dosage

Inside, while eating. 1/2-1 tablet 3 times a day.

Improvement is usually noted at the beginning of therapy.

A stable therapeutic effect occurs after two weeks of treatment and may increase over several months of treatment.

Long-term treatment. The duration of taking the drug is selected individually.

Overdose

Symptoms:  nausea, vomiting, convulsions.

Treatment:  gastric lavage, taking activated charcoal, symptomatic therapy.

Special instructions

Patients with a history of gastric or duodenal ulcer, pheochromocytoma, or bronchial asthma should be prescribed the drug under regular medical supervision.

Influence on the ability to drive motor vehicles and manage mechanisms

Betahistine has no sedative effect and does not affect the ability to drive a car or engage in activities that require rapid psychomotor reactions.

Storage conditions

Store in a dry place, protected from light, at a temperature not exceeding 25 °C

Shelf life

2 years

Active ingredient

Betahistine

Conditions of release from pharmacies

By prescription

Dosage form

Tablets

Description

For adults as prescribed by a doctor, For adults

Indications

Meniere’s disease, Cerebrovascular Accident