Braunodin B.Brown solution 7.5%, 1000ml, 10pcs

Composition

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of 100 g of the solution contains:

Active ingredient:

povidone-iodine (with an active iodine content of 10%) 7.5 g;

excipients:

sodium dihydrogen phosphate dihydrate,

lauromacrogol-400,

sodium iodate,

sodium hydroxide,

purified water up to 100 g.

Pharmacological action

Pharmacotherapy group: Antiseptic agentath: D. 08. A. G. 02 Povidone-Iodine Pharmacodynamics : Antiseptic agent, which is a complex of iodine and povidone, effective at pH from 2 to 7. The bactericidal effect is due to free active iodine, which is released from the povidone-iodine complex. In comparison with alcohol-containing solutions of iodine, an aqueous solution of povidone-iodine has a significantly lower irritant effect. Free iodine, as a strong oxidizer, reacts at the molecular level with insoluble fatty acids and practically non-oxidizing SH-and OH-groups of amino acids in the enzymes and main structural components of gram-positive and gram-negative bacteria, mycobacteria, fungi, especially the genus Candida, various viruses and some protozoa. However, for complete inactivation of some viruses and bacterial spores, a sufficiently long period of drug exposure is required. There are no known cases of resistance in microorganisms with prolonged use of povidone-iodine. Pharmacokinetics: After the use of povidone-iodine, some iodine absorption is possible, which must be taken into account depending on the place, amount and duration of use of the drug. If small amounts of the drug are applied to undamaged skin, then the absorption of iodine is insignificant. Increased absorption may be due to prolonged use of drugs containing povidone-iodine on mucous membranes, extensive wounds and burns, and especially after washing the cavities. As a result, there is a temporary increase in the content of iodine in the blood. In people with a healthy thyroid, a higher iodine content does not cause clinically significant changes in the state of the thyroid gland. During normal processes of iodine metabolism, excess iodine is removed through the kidneys.

Indications

Post-traumatic and post-operative wounds of various localization, burns, trophic ulcers, pressure sores, diabetic foot. Damage to the skin of various origins, maceration, abrasions, bruises. Skin infections of various etiologies, including infectious dermatitis and eczema. Treatment of the patient’s mucous membranes and skin before and after surgery, biopsy, and puncture, including the skin around drains, catheters, and probes. Hygienic treatment of hands of medical personnel, treatment of hands of surgeons. Infections of the oral and nasopharyngeal mucosa. Infections of the mucous membrane of the birth canal in women. Performing” small ” gynecological operations (artificial termination of pregnancy, introduction of an intrauterine device, coagulation of erosion and polyp).

Use during pregnancy and lactation

The drug is not recommended for use from the third month of pregnancy and during breastfeeding.

It is possible to use the solution in pregnant women up to the ninth week of pregnancy, when the expected benefit of treatment with the drug exceeds the possible risk of complications.

Contraindications

• Hypersensitivity to the components of the drug.
• Disorders of the thyroid gland (thyrotoxicosis).
• Thyroid adenoma.
• Duhring’s herpetiform dermatitis.
• Simultaneous use of radioactive iodine.
• Preterm infants, newborns, and children under 6 months of age.

With caution: Chronic renal failure.

Side effects

Hypersensitivity reactions to the drug are possible: delayed-type allergic reactions (itching, redness of the skin, blisters) or immediate-type allergic reactions (anaphylactoid reactions).

Prolonged use of the drug (more than 7-10 days) and application to large skin surfaces, extensive wounds due to absorption can cause phenomena of iodism (“metallic” taste in the mouth, increased salivation and lacrimation, swelling of the mucous membranes) and systemic reactions (metabolic acidosis, hyponatremia, impaired renal and thyroid function), if they occur, stop using the drug and consult a doctor.

Interaction

The drug is incompatible with alkaloid salts (celandine), tannic acid (tannin), salicylic acid, silver salts, bismuth, taurolidine and hydrogen peroxide.

In the presence of blood and pus, the drug binds to proteins and other organic compounds, as a result of which its bactericidal activity may decrease. In this case, it is recommended to increase the frequency of use of the drug.

Concomitant use of povidone-iodine and topical preparations containing enzymes may contribute to the oxidation and suppression of their enzymatic activity. Povidone-iodine has a synergistic effect with lithium preparations, as a result of which, if they are used together for a long time, reversible inhibition of thyroid function is possible. Therefore, patients who are constantly taking lithium preparations should avoid prolonged application of povidone-iodine on large surfaces.

The drug can lead to false-positive results in some diagnostic tests: determination of hemoglobin or sugar in the urine and stool, examination of thyroid function. Examination of the thyroid gland in this case should be carried out no earlier than 1-2 weeks after the end of povidone-iodine treatment.

How to take, course of use and dosage

Externally, locally. The drug is used in the form of a 7.5% solution or in diluted form. 0.9% sodium chloride solution, Ringer’s solution, and phosphate buffer solution can be used to dilute the drug. Povidone-iodine is applied to the surface by smearing using a swab soaked in the solution, irrigation using a mechanical spray gun, and also leave napkins soaked in the solution on the surface. The preparation in the form of a 7.5% solution is used for antiseptic treatment of shallow wounds, burns, skin injuries: abrasions, bruises; for treating the patient’s skin and mucous membranes before and after surgery, biopsy or puncture, skin around drains, catheters and probes. When treating the skin before surgery, it is necessary to use a solution, avoiding its “accumulation” under the patient, as this can cause skin irritation. To treat the hands of surgical personnel,5 ml of the drug in the form of a 7.5% solution is applied to the skin of the hands and treated for 2.5 minutes. The procedure is repeated twice. For hygienic treatment of hands, apply 3 ml to the skin and treat them for 1 min. Then rinse thoroughly with water. The drug in diluted form is used: – in a dilution of 1: 2-1: 20 for washing deep wounds, bedsores, trophic ulcers, during intraoperative wound treatment; – in a dilution of 1: 25 for preoperative preparation of patients: washing limbs;- in a dilution of 1: 100 for preoperative preparation of patients: body washing;- in the form of a 1% solution when diluted with phosphate buffer solution: application to the eye mucosa. All solutions of the drug are used only freshly prepared. Povidone-iodine solutions should be applied to the damaged surface until it is completely moistened. On the sutures of wounds apply napkins soaked in a solution of povidone-iodine. The antiseptic film formed when povidone-iodine dries is easily washed off with water. The use of povidone-iodine solutions should be continued until the signs of infection disappear or until the obvious risk of infection disappears. Povidone-iodine solutions do not irritate and do not slow down wound healing even with prolonged use.

Overdose

After extremely intensive absorption of iodine for an extended period, symptoms of hyperthyroidism may occur, such as tachycardia, agitation, trembling, and headache. Mild forms of hyperthyroidism sometimes do not require intervention, and severe forms may require thyrostatic therapy.

Special instructions

Avoid contact with undiluted drug in the eyes. Influence on the ability to drive vehicles and fur. : Not detected.

Form of production

Solution for external and topical use,7.5%.

Storage conditions

Store at a temperature of 2 to 25 °C in a place protected from light. Keep out of reach of children.

Shelf

life is 5 years.

Active ingredient

Povidone-Iodine

Dosage form

solution for topical application

Purpose

Children as prescribed by a doctor, Pregnant women as prescribed by a doctor, For adults

Indications

Bedsores, Stomatitis, Burns, Oral Inflammation, Thrush, Insect Bites, Wounds, Trophic Ulcers, Pyoderma, Periodontitis, Minor Skin injuries, Trichomoniasis