CardiASC pills 100mg, 30pcs

Composition

Tablets

Active ingredient:

acetylsalicylic acid;

Excipients:

corn starch,

lactose,

microcrystalline cellulose,

plasdon K-90,

calcium stearate,

tween-80,

collicut – 100 R,

plasdon S-630,

propylene glycol,

talc,

castor oil,

titanium dioxide.

Pharmacological action

of NSAIDs, antiplatelet agent. The main mechanism of action of Cardi ASK is irreversible inactivation of the cyclooxygenase (COX-1) enzyme, which blocks the synthesis of thromboxane A2 and suppresses platelet aggregation. Cardi ASK also has anti-inflammatory, antipyretic and analgesic effects.

Pharmacokinetics

Suction

After oral use, acetylsalicylic acid is absorbed in the upper small intestine. Cmax in blood plasma is reached 3 hours after oral use.

Metabolism

Acetylsalicylic acid is partially metabolized in the liver to form less active metabolites.

Deduction

It is excreted by the kidneys both in unchanged form and in the form of metabolites. T1 / 2 for acetylsalicylic acid is 15 minutes, for metabolites – about 3 hours.

Indications

— prevention of acute myocardial infarction in the presence of risk factors (including diabetes, hyperlipidemia, hypertension, obesity, Smoking, older age) and repeated myocardial infarction;

unstable angina;

— prevention of stroke (including in patients with transient disorders of cerebral circulation);

— prevention of transient disorders of cerebral circulation;

— prevention of thromboembolism after surgery and invasive procedures on vessels (including coronary artery bypass grafting, endarterectomy of the carotid arteries, arteriovenous bypass grafting, angioplasty of the carotid arteries);

— prevention of deep vein thrombosis and thromboembolism of the pulmonary artery and its branches (including during prolonged immobilization as a result of extensive surgery).

Contraindications

— erosive-ulcerative lesions of the gastrointestinal tract;

gastrointestinal bleeding;

— bronchial asthma induced by ingestion of salicylates and NSAIDs;

— “aspirin triad” (a triad of Fernand-of Vidal: a combination of bronchial asthma, recurrent polyposis of the nose and paranasal sinuses and intolerance of acetylsalicylic acid);

hemorrhagic diathesis;

— concomitant use with methotrexate at a dose of 15 mg per week or more;

— liver failure;

renal failure;

and III trimester of pregnancy;

— lactation (breastfeeding);

— age under 18 years;

— hypersensitivity to acetylsalicylic acid and other NSAIDs.

With caution Cardi ASK is prescribed for gout, hyperuricemia, as well as patients with a history of ulcerative lesions of the gastrointestinal tract or gastrointestinal bleeding, bronchial asthma, chronic respiratory diseases, hay fever, nasal mucosa polyposis, allergic reactions to medications, when combined with methotrexate in doses of less than 15 mg per week, with a deficiency of vitamin K and glucose-6-phosphate dehydrogenase.

Side effects

Allergic reactions: urticaria, angioedema.

From the digestive tract: nausea, heartburn, vomiting, abdominal pain, ulcers of the gastric and duodenal mucosa, including perforating, gastrointestinal bleeding, increased activity of “liver” enzymes.

From the respiratory system: bronchospasm.

Immune system disorders: anaphylactic reactions.

From the hematopoietic system: anemia (rarely), increased bleeding.

From the central nervous system: dizziness, tinnitus.

Interaction

When used simultaneously, ASA enhances the effect of the following medications: :

– methotrescate due to a decrease in renal clearance and its displacement from protein binding;

– heparin and indirect anticoagulants due to impaired platelet function and displacement of indirect anticoagulants from protein binding;

– thrombotic and antiplatelet drugs (ticlopidine);

– digoxin due to a decrease in its renal excretion;

– antidiabetic drugs (insulin and sulfonylurea derivatives) due to the hypoglycemic properties of ASA itself in high doses and the displacement of sulfonylurea derivatives from the bond with proteins;

– valproic acid due to its displacement from the bond with proteins.

An additive effect is observed when ASA is taken simultaneously with alcohol.

ASA weakens the effect of uricosuric drugs (benzbromarone) due to competitive tubular elimination of uric acid.

By increasing the elimination of salicylates, systemic glucocorticosteroids (corticosteroids) weaken their effect.

How to take, course of use and dosage

Cardi ASK® should be taken orally, before meals, with plenty of fluids. Cardi ASK® is intended for long-term use. The duration of therapy is determined by the attending physician. – Prevention of suspected acute myocardial infarction 100-200 mg / day or 300 mg every other day (the first tablet should be chewed for faster absorption). – Prevention of first-time acute myocardial infarction in the presence of risk factors of 100 mg per day or 300 mg every other day. – Prevention of recurrent myocardial infarction. Unstable angina pectoris. Prevention of stroke and transient cerebrovascular accident. Prevention of thromboembolic complications after surgery or invasive research 100-300 mg per day-Prevention of deep vein thrombosis and pulmonary embolism and its branches 100-200 mg per day or 300 mg every other day.

Overdose

Symptoms of moderate Cardi ASK overdose: Nausea, vomiting, tinnitus, hearing loss, dizziness, confusion.

Treatment:

Reducing the dose of the drug. Symptoms of severe Cardi ASK overdose:

Fever, hyperventilation, ketoacidosis, respiratory alkalosis, coma, cardiovascular and respiratory failure, severe hypoglycemia. Treatment: immediate hospitalization in specialized departments for emergency therapy-gastric lavage, determination of the acid-base state, alkaline and forced alkaline diuresis, hemodialysis, use of solutions, activated charcoal, symptomatic therapy. When performing alkaline diuresis, it is necessary to achieve pH values between 7.5 and 8. Forced alkaline diuresis should be performed when the concentration of salicylates in blood plasma is more than 500 mg/l (3.6 mmol/l) in adults and 300 mg / l (2.2 mmol/l) in children.

Special instructions

Cardi ASK should be used after a doctor’s appointment.

ASA can provoke bronchospasm, as well as cause attacks of bronchial asthma and other hypersensitivity reactions.

Risk factors include a history of bronchial asthma, hay fever, nasal polyposis, chronic respiratory diseases, and allergic reactions to other medications (for example, skin reactions, pruritus, and urticaria).

ASA can cause bleeding of varying degrees of severity during and after surgery.

The combination of ASA with anticoagulants, thrombolytics and antiplatelet drugs is associated with an increased risk of bleeding.

ASA in low doses can provoke the development of gout in predisposed individuals (with reduced uric acid excretion).

The combination of ASA with methotrexate is accompanied by an increased frequency of side effects from the hematopoietic system.

High doses of ASA have a hypoglycemic effect, which should be taken into account when prescribing it to patients with diabetes mellitus receiving hypoglycemic drugs. When prescribing corticosteroids and salicylates, it should be remembered that during treatment, the level of salicylates in the blood is reduced, and after the withdrawal of corticosteroids, an overdose of salicylates is possible.

The combination of ASA with ibuprofen is not recommended, as the latter worsens the beneficial effect of ASA on life expectancy.

Excess of the ASA dose is associated with the risk of gastrointestinal bleeding.

Overdose is especially dangerous in elderly patients.

When ASA is combined with alcohol, the risk of damage to the gastrointestinal mucosa and prolongation of bleeding time is increased.

Active ingredient

Acetylsalicylic acid

Dosage form

Tablets

Purpose

Adults who are only pregnant in the second trimester as prescribed by a doctor

Indications

Prevention of heart attacks and strokes, Cerebral circulation disorders, Prevention of thromboembolism, Prevention of thrombosis, Prevention of acute myocardial infarction, Angina