Cardiket, retard pills 40mg, 20pcs

Composition

Active ingredient:

isosorbide dinitrate 40 mg;

Auxiliary substances:  

lactose monohydrate;

talc;

magnesium stearate;

polyvinyl acetate;

potato starch

Pharmacological action

Cardiket is a vasodilator.

Pharmacodynamics

Isosorbide dinitrate causes relaxation of the smooth muscle wall of blood vessels, thus inducing vasodilation. Isosorbide dinitrate acts as a peripheral vasodilator, affecting both arteries and veins. These effects contribute to the deposition of venous blood and reduce venous return to the heart, reducing end dBP and left ventricular volume (reduce preload).

A long-acting cardiket is characterized by a combination of rapid onset of effect and duration of action.

The advantages of the drug are determined by the fact that the Active ingredient contained in the Cardiket®tablet of prolonged action quickly enters the bloodstream. As a result, the drug provides a rapid onset of effect in the treatment of angina pectoris and retains its protective effect for a long time.

Pharmacokinetics

When taken orally, isosorbide dinitrate is rapidly absorbed. Oral bioavailability is 22% (the effect of “first pass” through the liver). The onset of action is in 15-30 minutes, the_cmax of the substance in the blood plasma is reached in 15 minutes — 1-2 hours. As a result of passing through the liver, isosorbide dinitrate is metabolized to form isosorbide-2-mononitrate and isosorbide-5-mononitrate, which have T_1/2of 1.5-2 and 4-6 hours, respectively. Both metabolites are pharmacologically active. It is excreted by the kidneys (almost entirely in the form of metabolites). Binding to plasma proteins is 30%.

Indications

• attacks of all forms of angina
• prevention of angina
• acute myocardial infarction
• chronic heart failure.

Contraindications

• acute phase of myocardial infarction
• marked decrease in blood pressure
• hypersensitivity to the drug Cardiket

Side effects

From the cardiovascular system:  at the beginning of treatment-severe headache (due to dilation of the venous bed of the brain vessels); possibly-tachycardia, orthostatic hypotension.

From the central nervous system :  drowsiness.

From the gastrointestinal tract:  in some cases-nausea, vomiting.

Dermatological reactions:  in some cases – erythematous rashes.

Interaction

Simultaneous use of Cardiket retard with antihypertensive drugs, cyclic antidepressants, MAO inhibitors may increase its hypotensive effect.

When used simultaneously, Kardiket retard potentiates the action of dihydroergotamine and ethanol.

How to take, course of use and dosage

The dose is selected individually, since it depends on the stage of the disease and the individual need for nitrates. Tablets are prescribed for 1 tab. 2-3 times /day,

Kardiket should be taken after a meal, without chewing and with a small amount of liquid.

When prescribing more than 1 tab. /day, the interval between doses should be at least 8 hours (to ensure the full effect of the drug).

Overdose

Symptoms:  headache, palpitations, dizziness, hypotension, nausea, vomiting.

Treatment:  symptomatic.

Special instructions

Cardiket retard should not be prescribed for the purpose of stopping an angina attack.

Severe headache that occurs at the beginning of therapy, in most cases significantly decreases or completely disappears with continued use of the drug.

Alcohol consumption should be avoided during treatment with Cardiket.

Influence on the ability to drive motor vehicles and manage mechanisms

The possibility of engaging in potentially dangerous activities should be considered only after evaluating the individual patient’s response to the drug.

Form of production

Long-acting tablets.

Storage conditions

At a temperature not exceeding 25 °C

Shelf life

5 years

Active ingredient

Isosorbide dinitrate

Conditions of release from pharmacies

By prescription

Dosage form

long-acting tablets

Indications

Prevention of acute myocardial infarction, Chronic circulatory failure, Angina Pectoris