Cefecon D, rectal suppositories for children 250mg 10pcs

Composition

One suppository contains:  

Active ingredient:  

Paracetamol — 50 mg,100 mg or 250 mg;

Basics for suppositories:  

Solid fat (vitepsol, supposir) — before receiving a suppository weighing 1.25 g.

Pharmacological action

Pharmaceutical group:

analgesic non-narcotic drug.

Pharmaceutical action:

Cefecon D is a non-narcotic analgesic that blocks COX 1 and COX 2 mainly in the central nervous system, affecting the pain centers and thermoregulation.

In inflamed tissues, cellular peroxidases neutralize the effect of paracetamol on COX, which explains the almost complete absence of an anti-inflammatory effect.

The absence of a blocking effect on Pg synthesis in peripheral tissues means that it has no negative effect on water-salt metabolism (Na+ and water retention) and the gastrointestinal mucosa.

Indications

Cefecon D 250 mg is used in children from 3 to 12 years of age as:

• an antipyretic agent for acute respiratory infections, flu, childhood infections, post-vaccination reactions and other conditions accompanied by an increase in body temperature;
• an analgesic agent for pain syndrome of mild to moderate intensity, including headache and toothache, muscle pain, neuralgia, pain from injuries and burns.

Contraindications

• Hypersensitivity to the components of Cefecon D;
• age up to 1 month of life.
• With caution:
• disorders of liver and kidney function;
• Gilbert’s syndrome; Dubin-Johnson and Rotor;
• diseases of the blood system (anemia, thrombocytopenia, leukopenia);
• genetic absence of the enzyme glucose-6-phosphate dehydrogenase.

Side effects

From the digestive tract: nausea, vomiting, abdominal pain.

Allergic reactions: itching, rash on the skin and mucous membranes, urticaria, angioedema.

Hematopoietic disorders: anemia, leukopenia, agranulocytosis, thrombocytopenia.

With prolonged use in large doses — hepatotoxic and nephrotoxic effects (interstitial nephritis, papillary necrosis), hemolytic anemia.

Interaction

Stimulators of microsomal oxidation in the liver (phenytoin, ethanol, barbiturates, flumecinol, rifampicin, phenylbutazone, tricyclic antidepressants), ethanol and hepatotoxic drugs increase

the production of hydroxylated active metabolites, which causes the possibility of severe intoxication, even with a small overdose.

Microsomal oxidation inhibitors (including cimetidine) reduce the risk of hepatotoxic effects. When taken together with salicylates, the nephrotoxic effect of paracetamol increases.

The combination with chloramphenicol leads to an increase in the toxic properties of the latter. Increases the effect of indirect anticoagulants, reduces the effectiveness of uricosuric drugs.

How to take, course of use and dosage

Rectally, after a cleansing enema or spontaneous bowel movement. The dosage of Cefecon D is calculated depending on age and body weight, in accordance with the table.

The average single dose is 10-15 mg / kg 2-3 times a day after 4-6 hours. The maximum daily dose of acetaminophen should not exceed 60 mg/kg

1-3 months (4-6 kg) – 1 supp. 50 mg (50 mg);

3-12 months (7-10 kg) – 1 supp. 100 mg (100 mg);

from 1 to 3 years (11-16 kg) – 1-2 supp. 100 mg (100-200 mg);

from 3 to 10 years (17 to 30 kg) – 1 supp. 250 mg (250 mg);

from 10 to 12 years of age (31-35 kg) – 2 supp. 250 mg (500 mg).

Overdose

Symptoms:  

during the first 24 hours after use — pallor of the skin, nausea, vomiting, anorexia, abdominal pain; impaired glucose metabolism, metabolic acidosis.

Symptoms of impaired liver function may appear 12-48 hours after an overdose.

In severe overdose — liver failure with progressive encephalopathy, coma, death; acute renal failure with tubular necrosis (including in the absence of severe liver damage); arrhythmia, pancreatitis.

The hepatotoxic effect in adults is manifested when taking 10 g or more.

Treatment:  

use of SH-group donors and glutathione — methionine synthesis precursors 8-9 hours after overdose and N-acetylcysteine-12 hours later.

The need for further therapeutic measures (further use of methionine, intravenous use of N-acetylcysteine) is determined depending on the concentration of paracetamol in the blood, as well as the time elapsed after taking it.

Special instructions

If the fever persists for more than 3 days and the pain syndrome persists for more than 5 days, consult your doctor. Concomitant use of paracetamol with other paracetamol-containing medications should be avoided, as this may cause an overdose of paracetamol. When using the drug for more than 5-7 days, peripheral blood parameters and the functional state of the liver should be monitored. Paracetamol distorts laboratory tests in the quantitative determination of glucose and uric acid in plasma.

Product

form Cefecon® D rectal suppositories for children of 50 mg,100 mg or 250 mg. 5 suppositories in a contour cell package; two contour cell packages together with instructions for medical use of the drug are placed in a cardboard box.

Storage conditions

In a dry place, at a temperature not exceeding 20 °C

Shelf life

3 years

Active ingredient

Paracetamol

Dosage form

rectal suppositories

Description

Children over 3 years old

Indications

Osteoarthritis, Migraines, Flu, Colds, Neuritis, Burns, Arthritis