Ceraxon [CDP Choline], oral solution 100mg/ml 10ml sachets 10pcs

Composition

>1 ml of the oral solution contains:

• Active ingredient:
• citicoline sodium (equivalent to 100 mg of citicoline) 
• auxiliary substances:
• sorbitol — 200 mg;
• glycerol,50 mg;
• methyl parahydroxybenzoate — 1,45 mg;
• parahydroxybenzoate — 0.25 mg;
• sodium citrate dihydrate — 6 mg;
• sodium saccharin 0.2 mg;
• flavor: strawberry (strawberry essence 1487-S-Lucta) — 0,408 mg;
• potassium sorbate — 3 mg;
• citric acid 50% solution to a pH of 6;
• purified water — up to 1 ml.

Pharmacological action

Ceraxon – is a nootropic drug.

Citicoline, being a precursor of key ultrastructural components of the cell membrane (mainly phospholipids), has a wide spectrum of action: promotes the restoration of damaged cell membranes, inhibits the action of phospholipases, preventing excessive formation of free radicals, and also prevents cell death by affecting the mechanisms of apoptosis.

In the acute period of stroke, citicoline reduces the amount of damage to brain tissue, improves cholinergic transmission.

With traumatic brain injury, it reduces the duration of post-traumatic coma and the severity of neurological symptoms, in addition, citicoline helps to reduce the duration of the recovery period.

In chronic brain hypoxia, citicoline is effective in the treatment of cognitive disorders such as memory loss, lack of initiative, difficulties in performing daily activities and self-care. Increases the level of attention and consciousness, and also reduces the manifestation of amnesia.

Ceraxon® is effective in the treatment of sensory and motor neurological disorders of degenerative and vascular etiology.

Indications

• acute period of ischemic stroke (as part of complex therapy);
• recovery period of ischemic and hemorrhagic strokes;
• TBI, acute (as part of complex therapy) and recovery period;
• cognitive and behavioral disorders in degenerative and vascular diseases of the brain.

Use during pregnancy and lactation

There are no sufficient data on the use of citicoline in pregnant women.

Although no adverse effects have been identified in animal studies, Ceraxon® is prescribed during pregnancy only when the expected benefit to the mother outweighs the potential risk to the fetus.

When prescribing Ceraxon® during lactation, women should stop breastfeeding, since there are no data on the excretion of citicoline in human milk.

Contraindications

• hypersensitivity to any of the components of the drug;
• severe vagotonia (predominance of the tone of the parasympathetic part of the autonomic nervous system);
• rare hereditary diseases associated with fructose intolerance;
• children under 18 years of age (due to lack of sufficient clinical data).

Side effects

Very rare (less than 1/10000) (including individual cases): allergic reactions (rash, pruritus, anaphylactic shock), headache, dizziness, fever, tremor, nausea, vomiting, diarrhea, hallucinations, edema, shortness of breath, insomnia, agitation, decreased appetite, numbness in paralyzed limbs, changes in the activity of liver enzymes.

In some cases, Ceraxone may stimulate the parasympathetic system, as well as cause a short-term change in blood pressure.

If any of the side effects listed in the instructions get worse, or any other side effects that are not listed in the instructions are noticed, you should inform your doctor.

Interaction

Citicoline may increase the effect of levodopa on the body.

Treatment with Ceraxone is not performed at the same time as medications that contain meclofenoxate.

How to take, course of use and dosage

The drug is taken during meals or between meals. Before use, the drug can be diluted in a small amount of water (120 ml or 1/2 cup).

Acute period of ischemic stroke and traumatic brain injury:  The recommended dose is 1000 mg (10 ml) every 12 hours. The duration of treatment is at least 6 weeks.

Recovery period of ischemic and hemorrhagic strokes, recovery period of traumatic brain injury, cognitive and behavioral disorders in degenerative and vascular diseases of the brain:  the recommended dose is 500-2000 mg / day (5-10 ml 1-2 times/day).

The dose and duration of treatment depend on the severity of the symptoms of the disease.

Overdose

Taking into account the low toxicity of the drug, cases of overdose are not described.

Special instructions

During the treatment period, care should be taken when performing potentially dangerous activities that require special attention and quick reactions (driving a car and other vehicles, working with moving mechanisms, working as a dispatcher and operator, etc. ).

Solution for oral use (optional).

In the cold, a small amount of crystals may form due to temporary partial crystallization of the preservative.

If further stored under the recommended conditions, the crystals dissolve within a few months.

The presence of crystals does not affect the quality of the drug.

Form of production

Solution for oral use: clear, colorless liquid with a characteristic strawberry smell.

Storage conditions

At a temperature not exceeding 30 °C

Shelf life

3 years

Active ingredient

Citicoline

Conditions of release from pharmacies

By prescription

Dosage form

solution for oral use

Description

For adults as directed by your doctor

Indications

Consequences of stroke, Acquired dementia, Alzheimer’s disease, Concussion and other traumatic brain injuries