Cereton solution 250mg/ml 4ml ampoules, 5pcs

Composition

1 ampoule (4 ml of solution for intravenous and intramuscular use) contains:

Active ingredient:

glycerylphosphorylcholine hydrate in terms of anhydrous glycerylphosphorylcholine (choline alfoscerate) – 1000 mg,

excipients:

water for injection-up to 4 ml

Pharmacological action

Pharmacodynamics

Cereton is a nootropic agent. Central cholinostimulator, which contains 40.5% of metabolically protected choline. Metabolic protection promotes the release of choline in the brain. Provides synthesis of acetylcholine and phosphatidylcholine in neuronal membranes, improves blood flow and enhances metabolic processes in the central nervous system, activates the reticular formation.

Increases the linear velocity of blood flow on the side of traumatic brain damage, contributes to the normalization of spatiotemporal characteristics: spontaneous bioelectric activity of the brain, regression of focal neurological symptoms and restoration of consciousness; has a positive effect on the cognitive and behavioral responses of patients with vascular diseases of the brain (dyscirculatory encephalopathy and residual phenomena of cerebral circulatory disorders).

It has a preventive and corrective effect on pathogenetic factors of involutional psychoorganic syndrome, changes the phospholipid composition of neuronal membranes: it participates in the synthesis of phosphatidylcholine (membrane phospholipid), improves the plasticity of neuronal membranes. It stimulates the dose-dependent release of acetylcholine under physiological conditions, improves synaptic transmission, and receptor function. It does not affect the reproductive cycle and has no teratogenic, mutagenic effect.

Pharmacokinetics

When taken parenterally (10 mg/kg), Ceretone mainly accumulates in the brain, lungs, and liver. Absorption – 88%, easily penetrates the blood-brain barrier (when taken orally, the concentration in the brain is 45% of that in plasma).85% of the drug is excreted by the lungs in the form of carbon dioxide, the remaining amount (15%) is excreted by the kidneys and through the intestines.

Indications

• acute and recovery periods of severe traumatic brain injury and ischemic stroke, the recovery period of hemorrhagic stroke, occurring with a focal hemispheric symptoms or symptoms of lesions of the brain stem;
• psycho-organic syndrome on the background of involution and degenerative changes in the brain;
• cognitive disorders (disorders of mental function, memory, confusion, disorientation, decreased motivation, initiative and ability to focus), including dementia and encephalopathy;
• senile pseudomalachite

Use during pregnancy and lactation

The use of the drug Tsereton during pregnancy and lactation is contraindicated.

Breast-feeding should be discontinued during treatment with Cereton.

Contraindications

• hypersensitivity to the drug;
• acute stage of hemorrhagic stroke;
• pregnancy; breast-feeding period;
• children under 18 years of age (due to lack of data).

Side effects

Nausea may occur (mainly as a result of dopaminergic activation), in this case, the dose of the drug is reduced.

Allergic reactions.

From the digestive system: constipation, diarrhea, dryness of the oral mucosa, pharyngitis.

Nervous system disorders: headache, drowsiness, insomnia, aggressiveness, anxiety, nervousness, cerebral ischemia, convulsions, dizziness.

Skin disorders: rash, urticaria.

Other: pain at the injection site, increased urination.

How to take, course of use and dosage

In acute conditions,1000 mg (1 ampoule) is administered intravenously (slowly)or deeply intramuscularly per day for 10-15 days.

Overdose

Nausea may occur.

Treatment: symptomatic therapy.

Special instructions

Ceretone does not affect the speed of psychomotor reactions.

Form of production

Solution for intravenous and intramuscular use

Storage conditions

In a dark place, at a temperature not exceeding 25 °C

Shelf life

5 years

Active ingredient

Choline alfoscerate

Conditions of release from pharmacies

By prescription

Dosage form

solution for injection and infusion