Citramon P pills, 10pcs

Product description

Minimum order quantity-5 pieces

Composition

Active ingredients:

acetylsalicylic acid-240 mg,

paracetamol-180 mg,

caffeine monohydrate or caffeine (caffeine anhydrous) – 30 mg.

Auxiliary substances:

cocoa-14 mg,

citric acid-5 mg,

potato starch-63 mg,

povidone low molecular weight (polyvinylpyrrolidone low molecular weight medical) – 4 mg,

talc-9 mg,

calcium stearate-5 mg

Pharmacological action

Combined drug.

Acetylsalicylic acid has an antipyretic and anti-inflammatory effect, relieves pain, especially caused by the inflammatory process, and also moderately inhibits platelet aggregation and thrombosis, improves microcirculation in the focus of inflammation.

Caffeine increases the reflex excitability of the spinal cord, excites the respiratory and vasomotor centers, expands the blood vessels of skeletal muscles, brain, heart, kidneys, reduces platelet aggregation; reduces drowsiness, fatigue. In this combination, caffeine in a small dose has almost no stimulating effect on the central nervous system, but it helps regulate the tone of brain vessels.

Paracetamol has analgesic, antipyretic and weak anti-inflammatory effects, which is associated with its effect on the center of thermoregulation in the hypothalamus and a weakly expressed ability to inhibit the synthesis of prostaglandins (Rd) in peripheral tissues.

Indications

Mild to moderate pain syndrome (of various origins): headache, migraine, toothache, neuralgia, myalgia, arthralgia, algodismenorrhea. Febrile syndrome: in acute respiratory diseases( ARI), influenza.

Use during pregnancy and lactation

It is contraindicated during pregnancy (I and III trimesters), during lactation.

Acetylsalicylic acid has a teratogenic effect; when used in the first trimester of pregnancy, it leads to malformation – cleavage of the upper palate; in the third trimester – to inhibition of labor (inhibition of prostaglandin synthesis), to closure of the arterial duct in the fetus, which causes hyperplasia of the pulmonary vessels and hypertension in the vessels of the small circulatory circle.

It is excreted in breast milk, which increases the risk of bleeding in the child due to impaired platelet function.

Children under 15 years of age should not be prescribed medications containing acetylsalicylic acid, since in the case of a viral infection, they can increase the risk of Reye’s syndrome. Symptoms of Reye’s syndrome include prolonged vomiting, acute encephalopathy, and enlarged liver.

Contraindications

Acute peptic ulcer of the stomach and duodenum; gastrointestinal bleeding (including in the anamnesis); severe liver and/or kidney function disorders, gout; hemorrhagic diathesis, hypocoagulation; surgical interventions accompanied by heavy bleeding; pregnancy (I and III trimester), lactation; glucose-6-phosphate dehydrogenase deficiency; glaucoma; hypersensitivity to the components of the drug, asthma, induced by the use of acetylsalicylic acid, salicylates and other nonsteroidal anti-inflammatory drugs; childhood (up to 15 years – the risk of developing Reye’s syndrome in children with hyperthermia on the background of viral diseases); increased excitability, sleep disorders; organic diseases of the cardiovascular system (including acute myocardial infarction, atherosclerosis); severe arterial hypertension; portal hypertension; avitaminosis K; hypoproteinemia.

With caution

Mild to moderate renal insufficiency, hepatic insufficiency with increased transaminase levels, benign hyperbilirubinemia (including Gilbert’s syndrome, alcoholic liver damage), alcoholism, epilepsy and a tendency to convulsive seizures, old age, gout, arterial hypertension.

Side effects

From the immune system:  hypersensitivity reactions, including anaphylaxis, anaphylactic shock, rhinitis, nasal congestion.

Skin and subcutaneous tissue disorders:  pruritus, rash on the skin and mucous membranes, including erythematous rashes; urticaria, angioedema, erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis.

Gastrointestinal disorders:  dyspeptic disorders, including nausea, vomiting, epigastric discomfort and pain, heartburn, abdominal pain; inflammation of the gastrointestinal tract, erosive and ulcerative lesions of the gastrointestinal tract, which can in rare cases cause gastrointestinal bleeding and perforation with appropriate laboratory and clinical manifestations.

Hepatobiliary disorders:  increased activity of liver enzymes, usually without jaundice, hepatonecrosis (dose-dependent effect).

Endocrine disorders:  hypoglycemia, up to hypoglycemic coma.

Neurological disorders:  headache, dizziness, tremor, paresthesia, fear, anxiety, agitation, irritability, sleep disturbance, insomnia, anxiety, general weakness, ringing in the ears.

Cardiac disorders:  tachycardia, palpitations, arterial hypertension.

Blood and lymphatic system disorders:  anemia, sulphate hemoglobinemia and methemoglobinemia (cyanosis, shortness of breath, heart pain), hemolytic anemia, due to the antiplatelet effect on platelets, acetylsalicylic acid may increase the risk of bleeding. Bleeding events such as intraoperative hemorrhages, hematomas, urogenital bleeding, nosebleeds, gum bleeding, gastrointestinal bleeding, and brain hemorrhages were observed.

Other:  bleeding can lead to acute and chronic post-hemorrhagic anemia/iron deficiency anemia (due to the so-called latent microbleeding) with appropriate laboratory manifestations and clinical symptoms, such as asthenia, pallor of the skin, hypoperfusion; non-cardiogenic pulmonary edema.

Interaction

Increases the effect of heparin, indirect anticoagulants, reserpine, steroid hormones and hypoglycemic drugs.

Concomitant use with other NSAIDs, methotrexate increases the risk of side effects.

Reduces the effectiveness of spironolactone, furosemide, antihypertensive drugs, as well as anti-gouty drugs that promote the elimination of uric acid.

Barbiturates, rifampicin, salicylamide, antiepileptic drugs and other stimulators of microsomal oxidation contribute to the formation of toxic metabolites of paracetamol that affect liver function.

Metoclopramide accelerates the absorption of paracetamol.

Under the influence of paracetamol, T1 / 2 of chloramphenicol increases by 5 times. Repeated use of paracetamol may increase the effect of anticoagulants (dicoumarin derivatives).

Concomitant use of paracetamol and ethanol increases the risk of hepatotoxic effects.

Caffeine accelerates the absorption of ergotamine.

How to take, course of use and dosage

of Citramon-P is taken orally (during or after meals) 1 tablet every 4 hours, with pain syndrome-1-2 tablets; the average daily dose is 3-4 tablets, the maximum daily dose is 8 tablets.

The course of treatment is no more than 3-5 days.

The drug should not be taken for more than 5 days as an analgesic and for more than 3 days as an antipyretic (without a doctor’s prescription and supervision).

Other dosages and dosage regimens are determined by the doctor.

Overdose

Symptoms (due to acetylsalicylic acid):  with mild intoxication – nausea, vomiting, gastralgia, dizziness, ringing in the ears; severe intoxication – lethargy, drowsiness, collapse, convulsions, bronchospasm, difficulty breathing, anuria, bleeding. Initially, central hyperventilation of the lungs leads to respiratory alkalosis (shortness of breath, suffocation, cyanosis, perspiration). As intoxication increases, progressive respiratory paralysis and uncoupling of oxidative phosphorylation cause respiratory acidosis.

Treatment:  constant monitoring of the acid-base balance and electrolyte balance; depending on the state of metabolism – the introduction of sodium bicarbonate, sodium citrate or sodium lactate. Increasing reserve alkalinity increases the excretion of acetylsalicylic acid by alkalizing the urine.

Special instructions

Caution should be exercised when prescribing the drug to patients with bronchial asthma and gout. It is not recommended to prescribe the drug to children, especially with chickenpox and flu, because of the high risk of developing Reye’s syndrome.

Do not prescribe Citramon simultaneously with barbiturates, anticonvulsants, salicylates, rifampicin.

Patients taking Citramon should refrain from drinking alcohol.

If it is necessary to prescribe the drug during pregnancy, the expected benefit to the mother and the potential risk to the fetus should be correlated. If necessary, short-term use of Citramon during lactation is not required to stop breastfeeding.

Form of production

Pills.

Storage conditions

Keep out of reach of children in the original packaging at a temperature not exceeding 25 °C.

Shelf

life is 3 years.

Active ingredients

: Acetylsalicylic acid, Caffeine, Paracetamol

Dosage form

Tablets

Purpose

Pregnant women only in the second trimester as prescribed by a doctor, Children over 15 years of age, For adults

Indications

Lumbago, Cold, Neuritis, Flu, Arthritis, Osteoarthritis, Migraine