Diltiazem Lannacher, sustained release pills 180mg 30pcs

Composition

Active ingredient:

diltiazem 0.18 g (180 mg);

Auxiliary substances:

lactose monohydrate,

poly (ethyl acrylate, methyl acrylate),

Eudrazhit NE30D,

a copolymer of methacrylic acid + Eudrazhit L100-55,

poly (ethyl acrylate, methyl methacrylate, trimethylammonium methylmethacrylate chloride),

Eudrazhit RS PM,

hydroxypropylmethyl cellulose,

magnesium stearate,

polyethylene glycol,

titanium dioxide,

talc,

anti-foaming agent SE2.

Pharmacological action

of Diltiazem Lannacher – antiarrhythmic, antihypertensive, vasodilator, antianginal.

By blocking calcium channels, it reduces the flow of calcium ions into myocardial cells. Causes dilation of the coronary arteries, thereby increasing coronary blood flow. Reduces the smooth muscle tone of peripheral arteries and OPSS.

Indications

• arterial hypertension
• angina
• pectoris supraventricular arrhythmias.

Contraindications

• marked decrease in heart rate
• disorders of intracardiac conduction
• chronic heart failure of II-III degree
• acute heart failure
• hypersensitivity to the drug Diltiazem Lannacher.

Side effects

From the nervous system and sensory organs: headache, dizziness, fainting states, increased fatigue, asthenia, sleep disorders, drowsiness, anxiety, extrapyramidal (Parkinsonism) disorders (ataxia, masked face, shuffling gait, stiffness of the hands or feet, trembling of the hands and fingers, difficulty swallowing), depression; when used in high doses – paresthesia, tremor, visual impairment (transient vision loss).

From the cardiovascular system: asymptomatic decrease in blood pressure; rarely-angina, arrhythmia (including flutter and ventricular fibrillation), bradycardia (less than 50 beats/min) or tachycardia, AV block II – III degree up to asystole, development or aggravation of heart failure; when used in high doses and with intravenous use-angina, bradycardia, AV block, pronounced decrease in blood pressure, aggravation of chronic heart failure.

From the digestive system: dry mouth, increased appetite, nausea, vomiting, constipation or diarrhea, increased activity of hepatic transaminases, gum hyperplasia (bleeding, soreness, swelling).

From the hematopoietic system: rarely-thrombocytopenia, agranulocytosis.

Interaction

Potentially dangerous are combinations with beta-blockers, quinidine, etc. class Ia antiarrhythmic drugs, cardiac glycosides (excessive bradycardia, slowing AV conduction, reduced myocardial contractility with the development of signs of HF). Procainamide, quinidine, etc. Drugs that cause prolongation of the Q-T interval increase the risk of its significant lengthening.

May increase the bioavailability of propranolol. Means for inhalation anesthesia (hydrocarbon derivatives), thiazide diuretics, etc. Drugs that reduce blood pressure increase the hypotensive effect of diltiazem. Cimetidine increases the concentration of diltiazem in the blood; phenobarbital, diazepam, rifampicin-reduce.

Increases the concentration of cyclosporine, carbamazepine, theophylline, quinidine, valproic acid and digoxin in the blood (dose reduction may be required). Simultaneous use of nitrates (including prolonged forms) is possible. Increases the cardiodepressive effect of general anesthetics.

Li+ preparations may increase the neurotoxic effects of diltiazem (nausea, vomiting, diarrhea, ataxia, trembling and / or tinnitus). Indometacin( and other NSAIDs), corticosteroids and estrogens, as well as sympathomimetic drugs reduce the hypotensive effect.

How to take, course of use and dosage

Tablets should be taken before meals, without chewing and washed down with a small amount of liquid.

The dosage regimen is set individually. Usually prescribed in a daily dose of 180-360 mg, divided into 2 doses.

When switching to long-term maintenance therapy, the dose of the drug can be reduced to 180 mg once a day, in the morning.

Overdose

Symptoms:

bradycardia, atrioventricular conduction disorders, hypotension.

Treatment:

depending on the severity of the overdose. It is necessary to wash the stomach, prescribe activated charcoal, and further treatment is symptomatic. If necessary, it is recommended to prescribe atropine, isoproterenol, dopamine or dobutamine, and also, with severe conduction disorders, electrocardiostimulation may be used.

Special instructions

Diltiazem of Lannacher use caution when AV blockade of I degree, disorders of intraventricular conduction, patients prone to hypotension, chronic heart failure, acute myocardial infarction with left ventricular failure, ventricular tachycardia with complex expansion ORS, liver failure, renal insufficiency, in elderly patients, children (efficacy and safety not investigated).

Form of production

Tablets

Storage conditions

Store in a dry place, protected from light, at a temperature not exceeding 25 °C

Shelf life

3 years

Active ingredient

Diltiazem

Conditions of release from pharmacies

By prescription

Dosage form

long-acting tablets

Description

For adults as directed by your doctor

Indications

Hypertension, Arrhythmia, Angina