Dipyridamol-FPO pills 75mg, 40pcs

Composition

1 coated tablet contains:

Active ingredient:

dipyridamole 75 mg;

Auxiliary substances:

lactose monohydrate – 39.2 mg,

microcrystalline cellulose-60 mg,

croscarmellose sodium-6 mg,

copovidone-8 mg,

magnesium stearate-1.8 mg.

Shell composition:

hypromellose-2.48 mg,

polysorbate-80-0.48 mg,

quinoline yellow dye-0.04 mg,

titanium dioxide-1 mg

Pharmacological action

Antiplatelet agent, angioprotector, immunomodulator. It has an inhibitory effect on platelet aggregation, improves microcirculation.

It has a vasodilating effect, reduces the resistance of resistive coronary vessels (mainly arterioles), increases the volumetric velocity of coronary blood flow. It is able to reduce perfusion of ischemic areas of the myocardium.

The mechanism of action is not fully understood.

It is believed that dipyridamole increases the content of adenosine (disrupting its reuptake), and also contributes to an increase in cAMP concentration due to inhibition of the PDE enzyme.

As a pyrimidine derivative, dipyridamole is an interferon inducer and has a modulating effect on the functional activity of the interferon system, increases the reduced production of interferon alpha and interferon gamma by blood leukocytes in vitro.

Increases non-specific resistance to viral infections.

Indications

Treatment and prevention of ischemic cerebral circulatory disorders, dyscirculatory encephalopathy.

Prevention of arterial and venous thrombosis and their complications, prevention of thromboembolism after heart valve replacement surgery.

Prevention of placental insufficiency in complicated pregnancy.

As part of complex therapy for any microcirculation disorders.

As an interferon inducer and immunomodulator for the prevention and treatment of influenza, acute respiratory viral infections.

Contraindications

· Acute myocardial infarction, unstable angina, common stenosing atherosclerosis of the coronary arteries.

· Subaortic aortic stenosis

· Decompensated heart failure

· Hypertrophic obstructive cardiomyopathy

· Hypotension and hypertension

· Severe cardiac arrhythmias

* Hemorrhagic diathesis

· Diseases with a tendency to bleed (peptic ulcer of the stomach and duodenum, etc. )

* Chronic obstructive pulmonary disease

· Hepatic and / or renal insufficiency

* Hypersensitivity to the components of the drug.

With caution Lactation period, children’s age (up to 12 years – lack of sufficient experience).

Side effects

Palpitations, bradycardia, thrombocytopenia, changes in the functional properties of platelets, bleeding, ear congestion, noise in the head, arthritis.

Vomiting, diarrhea, epigastric pain, and symptoms such as weakness, dizziness, nausea, headache, myalgia, and rhinitis may occur.

Usually, these side effects disappear with prolonged use of Dipyridamole.

As a result of the potential vasodilating effect of Dipyridamole in high doses, it can cause arterial hypotension, a feeling of” hot flashes ” and tachycardia, and coronary theft syndrome (at doses of more than 225 mg per day).

Possible hypersensitivity reactions such as rash or urticaria.

If side effects occur, you should inform your doctor about this.

Interaction

Xanthine derivatives (coffee, tea) can weaken the vasodilating and antithrombotic effect of Dipyridamole.

The use of Dipyridamole simultaneously with direct and indirect anticoagulants (heparin) and thrombolytics or acetylsalicylic acid increases the risk of hemorrhagic complications, which should be taken into account when using it together.

Dipyridamole may increase the effect of antihypertensive drugs.

Dipyridamole may weaken the anticholinergic properties of cholinesterase inhibitors.

The antiplatelet effect is enhanced when taking cephalosporin antibiotics (cefamandol, cefaperazone, cefatetan), penicillin-type antibiotics, tetracyclines, chloramphenicol, beta-lactams, nicotinic acid.

Antacids reduce the maximum concentration due to reduced absorption.

How to take, course of use and dosage

Unless otherwise prescribed by your doctor, the following dosage regimens are recommended:

To reduce platelet aggregation, it is recommended to use Dipyridimol at a dose of 75-225 mg / day in several doses. In severe cases, the dose may be increased to 600 mg / day.

For the prevention of thromboembolic syndrome, stent thrombosis and coronary artery bypass grafts – on the first day,50 mg together with ASA, then 100 mg, the frequency of use is 4 times a day (canceled 7 days after surgery, provided that ASA is continued at a dose of 325 mg / day) or 100 mg 4 times a day for 2 days before surgery and 100 mg 1 hour after surgery (if necessary in combination with warfarin).

For the prevention of influenza and other acute respiratory diseases, especially during epidemics, take the following scheme: 50 mg / day 1 time in 7 days for 4-5 weeks.

To prevent relapses, in patients who often suffer from respiratory viral infections, Dipyridamole is recommended to be taken according to the scheme: 100 mg/day (2 times 50 mg with an interval of 2 hours) 1 time a week for 8-10 weeks.

Dipyridamole is recommended to be taken on an empty stomach, without chewing coated tablets, washed down with a small amount of liquid.

Overdose

Symptoms: short-term hypotension.

Treatment:  symptomatic (including management of vasopressor agents).

Form of production

coated tablets, yellow in color, round, biconvex in shape. The cross-section shows two layers.

Storage conditions

The drug should be stored out of the reach of children at a temperature not exceeding 25°C.

Shelf

life is 3 years.

Active ingredient

Dipyridamole

Conditions of release from pharmacies

By prescription

Dosage form

Tablets

Description

For adults as directed by your doctor

Indications

Microcirculation disorders, Thrombosis prevention, Cerebrovascular accident