Encetron-SOLOpharm solution 250mg/ml 4ml, 5pcs

Composition

The solution for oral use is colorless, yellowish or yellowish-brown, transparent.

Auxiliary substances:

non-crystallizing liquid sorbitol-200 mg,

anhydrous glycerol-50 mg,

sodium citrate (sodium citrate dihydrate) – 6 mg,

anhydrous citric acid – up to pH 5.0-7.0,

water for injection – up to 1 ml

Pharmacological action

Nootropic agent. Citicoline, being a precursor of key ultrastructural components of the cell membrane (mainly phospholipids), has a wide spectrum of action: promotes the restoration of damaged cell membranes, inhibits the action of phospholipases, preventing excessive formation of free radicals, and also prevents cell death by affecting the mechanisms of apoptosis.

In the acute period of stroke, it reduces the volume of damaged tissue, improves cholinergic transmission.

With traumatic brain injury, it reduces the duration of post-traumatic coma and the severity of neurological symptoms.

Citicoline improves the symptoms observed in hypoxia: memory loss, emotional lability, lack of initiative, difficulties in performing daily activities and self-care.

It is effective in the treatment of cognitive, sensory and motor neurological disorders of degenerative and vascular etiology.

Indications

Ischemic stroke (acute period); ischemic and hemorrhagic stroke (recovery period); traumatic brain injury (acute and recovery period); cognitive impairment in degenerative and vascular diseases of the brain.

Recommendations for use

When taken orally-200-300 mg 3 times / day.

IV for strokes and traumatic brain injury in the acute period-1-2 g / day, depending on the severity of the disease for 3-7 days, followed by switching to iv use or oral use.

In / m – 0.5-1 g / day.

Contraindications

Vagotonia (predominance of the tone of the parasympathetic part of the autonomic nervous system); children and adolescents under 18 years of age; hypersensitivity to citicoline.

Side effects

From the central nervous system and peripheral nervous system:  insomnia, headache, dizziness, agitation, tremor, numbness in paralyzed limbs.

From the digestive system:  nausea, decreased appetite, changes in the activity of liver enzymes.

Allergic reactions:  rash, itchy skin, anaphylactic shock.

Other services:  fever; in some cases-short-term hypotensive effect, stimulation of the parasympathetic nervous system.

The Citicoline interaction enhances the effects of L-dihydroxyphenylalanine.

Functional features

Since citicoline is a naturally occurring compound found in the body, a classical pharmacokinetic study cannot be performed due to the complexity of quantifying exogenous and endogenous citicoline.

Special instructions

Citicoline should not be used simultaneously with medications containing meclofenoxate.

Active ingredient

Citicoline

Conditions of release from pharmacies

By prescription

Dosage form

solution for injection