Exportal, sachets 10g, 10pcs

Composition

Lactitol monohydrate – 5 g or 10 g in a sachet,200 g or 500 g in plastic containers. Without excipients.

Pharmacological action

A laxative

ATX code: A 06 AD12

Pharmacological properties

In the large intestine, lactitol is broken down by the action of the intestinal flora into low-molecular organic acids, which leads to an increase in osmotic pressure in the large intestine, an increase in the volume of feces, their softening, facilitation of bowel movements and normalization of intestinal function. The laxative effect usually occurs within 24 hours after the use of the drug (the delay is due to the passage of the drug through the gastrointestinal tract). At the beginning of the course of treatment, the laxative effect of the drug may be delayed, the effect may occur on the second or third day of its use.

In patients with hepatic encephalopathy or hepatic coma (or precoma), the effect is achieved by migration of ammonia from the blood to the large intestine (due to a decrease in PH, an increase in osmotic pressure in the intestinal lumen), removal of trapped ammonium ions and other nitrogen-containing toxic substances from the colon. Lactitol suppresses proteolytic bacteria and increases the number of acidophilic bacteria, thus restoring the microbiome.

Pharmacokinetics.

Lactitol exerts its effect only in the large intestine, where it completely enters after ingestion. It is absorbed in minimal amounts in unchanged form (no more than 0.5-2% of the dose taken).

Indications

Constipation, the need to regulate the stool for medical purposes (bowel cleansing in preparation for endoscopic and X-ray examinations, surgical interventions on the rectum, anal sphincter and the area adjacent to it), intestinal dysbiosis.

Hepatic encephalopathy, hepatic precoma and coma, hyperammonemia.

Use during pregnancy and lactation

Due to the minimal absorption of lactitol, any adverse effects on the woman and fetus when using it during pregnancy are not expected. The drug can be taken during pregnancy if the potential benefit to the mother outweighs the potential risk to the fetus.

Due to minimal absorption, lactitol is not expected to enter breast milk. The drug can be taken during breastfeeding if the potential benefit to the mother outweighs the potential risk to the child.

Contraindications

Hypersensitivity to lactitol.

Lactase deficiency, fructose and galactose intolerance, galactosemia, glucose-galactose malabsorption syndrome.

Syndrome of complete or partial intestinal obstruction, suspected organic damage to the gastrointestinal tract, abdominal pain and rectal bleeding of unknown origin, inflammatory bowel diseases (rectocolitis, regional enteritis), previous violation of the water-salt balance.

Children under 1 year of age.

With caution

Exportal® should be used with caution in patients prone to water-salt balance disorders.

Side effects

At the beginning of treatment, abdominal discomfort, flatulence and, in rare cases, abdominal pain and bloating may occur. These phenomena, as a rule, disappear with continued use of the drug, as you adapt to it.

If increased doses are used for a long time in the treatment of hepatic encephalopathy in a patient, due to diarrhea, due to individual differences, diarrhea may occur in some patients even when taking the recommended dose of the drug. In this case, it is necessary to reduce the dose of the drug.

The frequency of side effects is classified in accordance with the recommendations of the world health organization: very often – at least 10%; often – not less than 1% but < 10%; infrequently – no more than 0.1% but < 1%; rarely – not less than 0.01%, but less than 0.1%; very rarely – less than 0.01%; frequency unknown – cannot be determined based on available data.

Disorders of the gastrointestinal tract

Rare: flatulence, abdominal pain, bloating, vomiting, diarrhea.

Very rare: nausea, anal itching.

Interaction

When co-use of Exportala® with enteric drugs of pH-dependent release should be taken into account that lactitol lowers the intestinal pH.

It is not recommended to use Exportal® within two hours after taking other medications.

How to take, course of use and dosage

Inside during meals, mixed with various beverages (water, tea, coffee, juices, etc. ) or liquid food.

For constipation and dysbiosis. The drug should be taken once, the entire daily dose at once, in one dose.

Children 1-6 years -2.5-5 g (1/2-1 teaspoon of powder) per day.

Children 6-12 years-5-10 g (1 – 2 teaspoons of powder) per day.

Children 12-16 years -10-20 g (2 – 4 teaspoons of powder) per day.

Adults: 20 g (4 teaspoons of powder) per day.

The drug should cause stools once a day; after the onset of a stable laxative effect for several days of using the drug, its dose can be reduced. In some cases, half of the recommended daily dose is sufficient to achieve the desired effect. :

Children 1-6 years – 1.25 -2.5 g (1/4-1/2 teaspoon of powder) per day.

Children 6-12 years – 2.5-5 g (1/2-1 teaspoon of powder) per day.

Children 12-16 years – 5-10 g (1 – 2 teaspoons of powder) per day.

Adults: 10 g (2 teaspoons of powder) per day.

The minimum course of therapy, after which you should seek medical advice, is 5 months. The use of the drug in children is recommended to be carried out under the supervision of a doctor.

When adjusting the stool for medical purposes. 20 g of the drug, diluted in 1 liter of water, is taken three times (at 12,15 and 18 hours) on the eve of medical procedures.

With hepatic encephalopathy, hepatic precoma and coma, hyperammonemia. The dose of the drug should be selected individually for each patient, depending on the severity of the disease and the individual reaction to the drug. The initial daily dose is usually 0.5-0.7 g per 1 kg of body weight. This dose is divided into three single doses. Take with meals. A dose should be selected that causes two “soft” stools per day.

Overdose

Symptoms: diarrhea, abdominal pain, and in rare cases, vomiting is possible. These phenomena are usually eliminated by reducing the dose of the drug.

Treatment: reduce the dose or discontinue the drug. Correction of possible violations of the water-salt balance.

Description

White crystalline powder

Special instructions

Lactitol has a low caloric content (2 kcal / g), does not affect the level of glucose in the blood and can be used in patients with diabetes mellitus.

During the entire course of use of the drug, increased fluid intake is desirable.

The use of Exportal® does not affect the psychomotor functions associated with driving a car or controlling machines and mechanisms.

Form of production

Powder for the preparation of a solution for oral use. 5 g or 10 g in single-dose sachets (sachets) made of polyethylene-coated paper or Polyethylene-a combined material based on paper, aluminum and polyethylene,2 sachets (sachets) are connected in 1 strip (divided along a perforated strip).

3,6 strips or 6,12 sachets (sachets) of 5 g, or 5,10 strips or 10,20 sachets (sachets) of 10 g together with the instructions for use are placed in a pack of cardboard.

200 or 500 g in a plastic container. Instructions for use are attached to the container.

Storage conditions

Store in a dry place, protected from light and out of reach of children.

Shelf

life is 5 years. Do not use after the expiration date indicated on the package.

Active ingredient

Lactitol

Dosage form

oral solution