Flexen, gel 2.5%, 30g

Composition

Active ingredient:

ketoprofen 2,5 g

Pharmacological action

Flexen is an NSAID, a derivative of propionic acid.

It has analgesic, anti-inflammatory and antipyretic effects. The mechanism of action is associated with inhibition of the activity of COX, the main enzyme of arachidonic acid metabolism, which is a precursor of prostaglandins, which play a major role in the pathogenesis of inflammation, pain and fever.

The pronounced analgesic effect of ketoprofen is due to two mechanisms: peripheral (indirectly, through suppression of prostaglandin synthesis) and central (due to inhibition of prostaglandin synthesis in the central and peripheral nervous systems, as well as the effect on the biological activity of other neurotropic substances that play a key role in the release of pain mediators in the spinal cord).

In addition, ketoprofen has anti-radikinin activity, stabilizes lysosomal membranes, and causes significant inhibition of neutrophil activity in patients with rheumatoid arthritis. Inhibits platelet aggregation.

Indications

Symptomatic treatment of pain syndrome of various origins, rheumatic and inflammatory diseases, including:

• osteoarthritis of various localization;
• ankylosing spondylitis;
• gout attack;
• rheumatoid arthritis and periarthritis;
• bursitis, tendinitis, tendosynovitis, synovitis;
• sciatica, sciatica;
• myalgia;
• bruises, dislocations and sprains of muscles;
• phlebitis, superficial thrombophlebitis, lymphangitis.

Contraindications

Hypersensitivity (including to other NSAIDs), acute gastrointestinal diseases, severe renal and hepatic dysfunction, leukopenia, thrombocytopenia, blood clotting disorders, hemorrhoids and proctitis (suppositories), pregnancy, breast-feeding, children under 15 years of age.

Side effects

From the nervous system and sensory organs: dizziness, headache, asthenia.

From the digestive tract: gastralgia, nausea, vomiting, diarrhea, flatulence, gastrointestinal hemorrhages.

Other: transient dysuria, allergic skin reactions (pruritus, urticaria).

How to take, course of use and dosage

Flexen gel: topically, apply a small amount of gel in a thin layer on the skin above the focus of inflammation and lightly rub 2-3 times a day.

The duration of treatment should not exceed 14 days without consulting a doctor.

Form of production

Gel

Storage conditions

At a temperature not exceeding 25 °C

Shelf life

3 years

Active ingredient

Ketoprofen

Dosage form

gel for external use

Description

Children over 6 years of age, Pregnant women in the first and second trimester as prescribed by a doctor, For adults

Indications

Osteochondrosis, Osteoarthritis, Osteoarthritis, Myositis, Swelling after injuries and operations, Periarthritis, Rheumatoid Arthritis, Bruises, Arthritis, Bursitis